Evaluation on Blood Chemistry in a Thoroughbred Neonate (1-day old) with Congenital Torticollis

양재혁,Yang, J.H. Korea National University of Agriculture and Fishe 2019 현장농업연구지 = Journal of practical agricultural resear Vol.21 No.2

There have been no reports on the laboratory screening of congenital torticollis in equine medicine. The purpose of this study was to evaluate the blood chemistry of a newborn female foal with congenital torticollis. The filly was born after a normal parturition period, and the clinical pathology results were as follows: biochemistry of the plasma showed significantly higher levels of CK, LDH, and Na than those in a normal foal. However, Cl level was remarkably lower than that of the control. In conclusion, the cells in the neck muscles influenced the clinical pathological value in the neonate. A disorder of the muscles as well as the bone problem, such as the cervical vertebrae, may have caused congenital torticollis. To our knowledge, this is the first report detailing the clinical pathology results in a newborn foal with torticollis. These laboratory results can be used as a reference for interpretation of pathology results in foals.

Thoroughbred 1세말에서 상업용 말 인플루엔자 백신접종 후 항체역가 추적

양재혁,박용수,Yang, J.H.,Park, Y.S. 국립한국농수산대학교 교육개발센터 2018 현장농업연구지 = Journal of practical agricultural resear Vol.20 No.1

The object of this study was to evaluate the change of antibody titers on virus strains after inoculation with commercial killed equine influenza (EI) vaccines in horses. Serum antibodies of 20 Thoroughbred yearlings were detected using hemagglutination inhibition test for 41 weeks. Second vaccination is inoculated 4 weeks after the initial vaccination. Most of antibody titers were not increased until 4 weeks after first vaccination. The highest titers were detected 6-10 weeks after vaccination. The titers were decreased slowly and maintained for 16 weeks after inoculation. We could barely detect the antibody 41 weeks after vaccination in most cases. Vaccine anergia were appeared in 3 horses (15%) but it depended on virus strains. A/Equine/La Plata/93(H3N8) strain that induce high and durable antibody responses was the most effective among three strains. This study presents the first comprehensive data on the endurance of antibody titers against EI. Our data also suggests that yearlings should be inoculated three times in order to maintaining optimal antibody titers against EI. We speculate the causes of anergia were vaccine break down or individual specificity. Further research is needed to investigate immunological unresponsiveness. This was the first study on strain of equine vaccine in Korea.

Prediction of Preterm Birth By Second Trimester Cervical Sonography In Twin Pregnancies

양재혁 ( J. H. Yang ) 대한산부인과학회 1998 대한산부인과학회 학술대회 Vol.82 No.-

쌍태임신시 태반유형 및 제대부착형태가 성장 불일치에 미치는 영향에 관한 연구

안현경(H . K . Ahn),양광문(K . M . Yang),홍성란(S . R . Hong),류현미(H . M . Rheu),김문영(M . Y . Kim),한정열(J . R . Han),최규홍(K . H . Choi),양재혁(J . H . Yang),김은성(E . S . Kim) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.11

N/A Object : The purpose of the study is to determine whether the type of placentation and abnormal cord insertion can affect discordant growth in twin gestation. Materials and methods : We investigated 422 sets of structually normal twin delivered at our twin clinic after 26 weeks of gestation from 1995-1997. All cases of placenta were examined for pathologic evaluation during the study periods. The type of placentation was divided into four groups: monochorionic monoamniotic placenta (n=4); monochorionic diamniotic placenta (n=62); dichorionic diamniotic fused placenta (n=163); dichorionic diamniotic separate placenta(n=193). Cord insertion was also divided into three groups: both side abnormal insertion (n=17); either side abnormal insertion (n=101); both side normal insertion (n=304). Intertwin weight discordancy was classified as mild form (15-25%) and severe form (>25%) by the degree of the discrepancy. Results : The results were as follows; 1. Of these 422 twin sets, 132 (31%) consisted of twin discordancy in weight by 15% or greater (mild form 19%, severe form 12%). 2. There are no significant difference in the frequencies of discordancy between MC twins and DC twins (31.8% vs 31.2%, p=0.97). 3. The prevalence of abnormal cord insertion was 16% and much more frequent in MC placenta than DC placenta (26.5% vs 14%, p=0.001). 4. Although mean gestational age at delivery and mean birth weight were significantly lower in either side abnormal cord insertion group than both side normal cord insertion group (35.7 vs 36.7weeks, p=0.004 : 2317 vs 2475gm, p=0.01), no difference in the frequency of discordancy was observed in these two groups (37.6% vs 29%, p=0.1). Conclusion : The type of placentation and/or abnormal cord insertion were not revealed to affect discordant growth in twin gestation.

다운증후군의 산전진단을 위한 다양한 선별검사의 기여율 비교 - 산전 및 신생아때 진단된 96 례 분석 -

한정열(J . Y . Han),김문영(Y. M . Kim),조준형(J . H . Cho),안현경(H . K . Ahn),류현미(H . M . Ryu),김진미(J . M . Kim),김영미(Y . M . Kim),박소연(S . Y . Park),한혜경(H . K . Han),이영호(Y . H . Lee),양재혁(J . H . Yang) 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.10

연구의 목적은 다운증후군을 산전진단하기 위한 다양한 산전선별검사 (나이; 35세 이상, 임산부 혈청 marker를 이용한 triple test, 초음파; 비정상 소견, 후경부 투명대 (nuchal translucency), 후경부두께 (nuchal fold thickness))의 기여율를 비교하기 위한 것이다. 1990년 1월부터 1999년 9월까지 본원에서 산전 및 산후에 진단된 례는 총 96례 이었다. 산전 및 신생아기에 진단된 다운증후군의 빈도는 각각 68례 (71 %), 28례 (29 %)였다. 다운증후군 태아를 임신했던 임산부의 평균연령은 33±5.7세이다. 다운증후군의 1,000분만당 연도별 빈도율은 1990년부터 1999년까지 각각 0.4, 1.3, 0.7, 0.7, 1.6, 0.7, 1.2, 2.2, 2.0, 그리고 2.3 (Y=0.28±0.18 year, P=0.01)이었다. 산전진단된 다운증후군의 비율 (%)은 지난 10년간 각각 0 (0/2), 43 (3/7), 50 (2/4), 25 (1/4), 56 (5/9), 100 (5/5), 71 (5/7), 78 (14/18), 78 (14/18), 그리고 89 (17/19) (Y=12.9±8.9 year, P=0.000) 이었다. 다운증후군을 산전진단하기 위한 다양한 산전선별 검사에 따른 기여율은 35세이상의 연령에 의하면 30.2±5.6 %, triple test의 경우 18.2±3.4 %, 초음파에 의한 경우 51.7±6.3 % 이며, 초음파에 의한 산전 선별 검사가 통계적으로 유의하게 연령이나 triple test에 의한 경우 보다 다운증후군의 산전진단에 기여율이 높았다. (P=0.008) 결론적으로 본 연구에 의하면 지난 10년 동안 다운증후군을 산전 진단하기 위한 여러 선별 검사방법의 적용은 효율적이었으며, 특히 초음파에서 다양한 소견을 이용한 다운증후군의 산전선별검사는 연령이나 triple test 보다는 더욱더 의미가 있다고 추론된다. Objective : The purpose of this study was comparison of the contribution rate for prenatal diagnosis of Down syndrome using various screening methods (Age: greater than or equal to 35 years old, Serum markers: Triple test, Ultrasonography: abnormal sonographic findings, nuchal translucency, nuchal fold thickness).Methods : Total 96 cases of Down syndrome, prenatally or postnatally diagnosed between Jan. 1990 and Sept. 1999, made up the study population. We got the contribution rate of various prenatal screening methods of down syndrome, and obtained the efficiency of various screening program applied for last 10 years. Results : The frequencies of Down syndrome confirmed in prenatal and postnatal were 68 (71%) and 28 (29%) in respectively. The mean age of mother of Down syndrome fetus was 33.0±5.7 years old. The frequency rate of Down syndrome was 0.4, 1.3, 0.7, 0.7, 1.6, 0.7, 1.2, 2.2, 2.0 and 2.3 a 1,000 deliveries from 1990 to 1999 (Y= 0.28+0.18 year, P=0.01). The percentage of Down syndrome diagnosed prenatally was 0 (0/2), 43 (3/7), 50 (2/4), 25 (1/4), 56 (5/9), 100 (5/5), 71 (5/7), 78 (14/18), 78 (14/18) and 89 (17/19) from 1990 to 1999 (Y= 12.9+8.9 year, P=0.000). The contribution rate of prenatal diagnosis for Down syndrome was 30.2±5.6% by age, 18.2±3.4% by triple test and 51.7±6.3% by ultrasonography, and was significantly difference among each screen methods (P=0.008). Conclusions : This study shows that our prenatal screening program is highly effective to detect Down syndrome and especially ultrasonographic findings (abnormal sono findings, Nuchal translucency, Nuchal fold thickness) may be more important than that of age or Triple test to detect the Down syndrome prenatally.

응급 주산기 자궁적출술의 5 년간 경험

안현경(H . K . Ahn),김은성(E . S . Kim),한정열(J . Y . Han),김문영(M . Y . Kim),류현미(H . M . Ryu),최규홍(K . H . Choi),양재혁(J . H . Yang) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.12

N/A Objective : To review the cases of peripartum hysterectomy in women delivered at a Hospital. Methods : This is a retrospective study of all cases of emergency peripartum hysterectomy performed between August 1994 and July 1998. Results : During the study period a total of 35 emergency peripartum hysterectomy was performed. The overall incidence was 0.9/1,000 deliveries. The mean age of patients was 33.7±0.8 years old, the median gravidity was 5 and mean gestational age was 37.7±0.4 weeks. The main indications for hysterectomy were massive bleeding due to abnormal placental adhesions or uterine atony. There was no maternal death, However, maternal morbidity was 34.3%. Conclusions : The data show abnormal adherent placentation as the primary cause for gravid hysterectomy. The data illustrate how the incidence of emergency peripartum hysterectomy increases significantly with increasing parity, especially when influenced by a current placenta previa or a prior cesarean section. Maternal morbidyity remained high although no maternal deaths occurred.

투명 발열패널 수월 제작을 위한 금속용액의 패턴 몰딩성형 공정 개발

김민욱(M. Kim),노현찬(H. Noh),정덕영(D. Jeong),조건희(G. Jo),김혜인(H. Kim),이원준(W. Lee),지호재(H. Ji),백현민(H. Baek),양재혁(J. Yang),옥종걸(J. G. Ok) 한국기계가공학회 2021 한국기계가공학회 춘추계학술대회 논문집 Vol.2021 No.12

염색체 이수성질환을 선별하기 위한 삼중 표지물질 검사의 성과에 관한 연구

최용관(Y. K. Choi),김문영(M. Y. Kim),한정열(J. Y. Han),류현미(H. M. Ryu),양재혁(J. H. Yang),김은성(E. S. Kim),이홍복(H. B. Lee),한인수(E .S. Kim),고명인(M. I. Ko),한호원(H. W. Han) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.9

본 연구 목적은 산모의 나이를 고려한 삼중 표지물질 검사가 다운 증후군과 에드워드 증후군을 선별하는데 효용성이 있는지 보고자 한다. 1994년 3월 1일부터 1996년 2월 28일까지 2년 동안 삼성제일병원에서 임신2기에 모체혈청 표지물질인 AFP, hCG, uE3를 이용한 삼중 표지물질 검사를 시행하였고 본원에서 분만한 5,308례의 단태 임신을 대상으로 하였다. 동시에 삼중 표지물질 검사를 이용한 에드워드증후군의 선별검사 대상은 1995년 11월부터 1996년 2월까지의 1,378례의 단태 임신을 대상으로 하였다. 연구방법은 Radioimmunoassay Kits를 이용하여 모체혈청에서 AFP, hCG, uE3의 농도를 측정하였으며, 또한 3가지 혈청 표지 물질의 농도는 태령에 따라서 MOM( Multiples of the median )으로 산출하였으며 각 표지물질의 기대 중앙값( Expected Median )은 AFP과 uE3은 log y = a + bx의 log linear regression을, 그리고 hcG는 Y = eA+Bx 의 non-linear regression 함수를 이용하여 산출하였다. 그리고, 측정된 각 혈청 표지 물질의 농도와 산모의 나이에 따른 다운증후군과 에드워드 증후군의 위험률은 alpha software version 4.1(Logical Medical system Ltd, London)를 이용하여 산출하였다. 다운증후군 산전검진 결과는, 총 5,308례 중 248례인 4.7%에서 검진(Screening) 양성으로 나와 양수천자를 권유하였고, 126례인 2.4%가 양수검사를 시행하여 최종적으로 7례의 다운 증후군이 진단되었다. 에드워드 증후군 산전검진 결과로서 1,378례가 검진되었고, 4례인 0.3%에서 양성으로 나왔다. 검진 양성인 1례는 삼중 표지물질 검사 직후 IUFD 되었고 태아 표피(skin)를 사용하여 염색체 검사를 시행했으나 실패하였다. 나머지 3례에서 양수천자에 따른 염색체 검사에서 2례의 에드워드 증후군을 진단 할 수 있었다. 다운증후군의 경우 발견률(detection rate)은 발생한 9례 중 7례를 선별하여 77.8%이며, 위양성률(false positive rate)은 4.5% 그리고 OAPR은 1:35이었다. 에드워드증후군의 경우 발견률(detection rate)은 100%이며, 위양성률(false positive rate)은 0.1% 그리고 OAPR은 1:2이었다. 이상의 결과들을 볼 때 이수성 질환의 산전 선별 검사로써 삼중 표지물질 검사가 의미 있는 검사라고 판단된다. Objective: To evaluate the effectiveness of a screening protocol using a combination of maternal age and three biochemical markers for the antenatal detection of fetal chromosomal aneuploidy Materials and methods: In our retrospective, 5,308 women who were screened for Down syndrome at second trimester of pregnancy and delivered between March 1994 and February 1996 at Samsung Cheil hospital were studied. Also, 1,378 women were simultaneously studied for screening for Edward syndrome between November 1995 and February 1996. According to maternal age and the concentration of measured maternal serum markers (α-fetoprotein, unconjugated E3, hCG), the risk ratio of Down syndrome and Edward syndrome were calculated by α-software V. 4.1. The screening positive women were performed amniocentesis for fetal karyotyping after genetic counseling. Results: The average age was 28 years old. The average of the geatational weeks was 16.3 weeks. The followings are equations of expected median for each maternal serum markers. AFP(ng/ml)=10(0.474+0.0652xGestational week) uE3(nmol/L)=10(-0.852+0.0932xGestational week) hCH(IU/ml)=217,523/[1+Exp(5.62+0.17xGestational week)] Among 5,308 cases, screen positive was in 248 cases(4.7%). But amniocentesis was performed in 126 cases(2.4%). Down syndrome was detected in 7 cases. The difference of the prevalance rate for Down syndrome between younger than 35 years old (1.2/1,000) and older than or equal to 35 years old(6.7/1,000) was statistically significant (P=0.035). However, in screen negative cases, Down syndrome was detected in 2cases. Overall, the detection rate, false positive for Down syndrome were 77.8%, 4.5% respectively and the ratio for OAPR was 1:35. In Edward syndrome, screen positive was in 4 cases(0.3%). Edward syndrome was confirmed in 2 cases by amniocentesis The detection rate, false positive for Edward syndrome were 100%, 0.1 % and the ratio for OAPR was 1:2. Conclusion: The prenatal screening test by the combination of maternal age and the concentration of maternal serum markers was effective to detect Down syndrom and Edward syndrome at second trimester of pregnancy.

불규칙교란을 받는 유연한 계의 확률론적 제어에 대한 새로운 기법

양재혁(JaeHyuk Yang),김대중(D.J. Kim),조윤현(Y.H. Cho),허훈(H. Heo) 한국항공우주학회 1998 한국항공우주학회 학술발표회 논문집 Vol.- No.-

금속이온용액의 코팅, 프린팅, 임프린팅 기반 나노포러스 메탈 정밀구조체 및 패턴의 수월 성형 및 응용소자 개발

옥종걸(J. G. Ok),김민욱(M. Kim),김광준(K. Kim),백현민(H. Baek),김태윤(T. Kim),양재혁(J. Yang) Korean Society for Precision Engineering 2022 한국정밀공학회 학술발표대회 논문집 Vol.2022 No.10