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망막분지정맥폐쇄로 인한 황반부종에서 허혈성과 비허혈성 간의 유리체강내 스테로이드주사의 효과 차이
최창욱,서상우,양연식.Chang Uk Choi M.D.. Sang Woo Seo M.D.. Yun Sik Yang M.D.. Ph.D. 대한안과학회 2007 대한안과학회지 Vol.48 No.1
Purpose: To investigate the improvement of visual acuity with the different effects of ischemic and perfusion type branched retinal vein occlusion (BRVO), and explore the relationship between defects of the macular capillary network and intravitreal injection of triamcinolone acetonide (IVTA) for treatment of BRVO secondary to macular edema. Methods: We compared macular capillary network condition, improvement of visual acuity due to ischemic range, and decrease of macular edema between 23 perfusion type BRVO patients and 21 ischemic type BRVO patients who were treated with IVTA for BRVO secondary to macular edema. Results: Both ischemic and perfusion type BRVO exhibited decreased macular edema and showed meaningful improvements in visual acuity (P<0.01), but did not show a relationship between the defects in the macular capillary network and improvement of visual acuity. No differences were seen in macular capillary network defects between ischemic and perfusion type BRVO. Conclusions: IVTA had an effect on the decrease in macular edema and improvement of visual acuity for both ischemic and perfusion type BRVO. However, defects in the macular capillary network do not seem to have any effect on the improvement of visual acuity.
당뇨망막병증에서 유리체강내 베바시주맙 주사 후 망막미세혈관류의 변화
최창욱,이승준,강혜라,양연식,Chang Wook Choi,MD,Seung Joon Lee,MD,Hye Ra Kang,MD,Yun Sik Yang,MD,PhD 대한안과학회 2014 대한안과학회지 Vol.55 No.10
Purpose: To evaluate microvascular change (microaneurysm) in diabetic retinopathy patients who undergo intravitreal bevacizumab injection using fluorescein angiography (FAG). Methods: Thirty one eyes of 31 diabetic retinopathy patients undergoing intravitreal bevacizumab injection (1.25 mg/0.05 mL) in only 1 eye were included in this study. The control group (31 eyes) consisted of the fellow eyes. We excluded cased with intravitreal bevacizumab injection in both eyes and medial opacity obscuring three fundus image due to vitreous hemorrhage. The microaneurysmal change was analyzed at the same site the circle with optic disc radius and macula using FAG 2 to 4 months after injection. Results: The average number of microaneurysms was 42.58 ± 33.93 and significantly decreased to 28.74 ± 28.06 after intravitreal bevacizumab injection (<EM>p </EM>< 0.05). The decrease of 35.70 ± 24.79% in the treatment group was statistically higher than 13.95 ± 38.21% in the control group with the fellow eyes (<EM>p</EM> < 0.05). Conclusions: In the present study, intravitreal bevacizumab injection reduced neovascularization, cystoid macular edema. Therefore this data can be used for future research on microvascular changes in the retina. J Korean Ophthalmol Soc 2014;55(10):1481-1486