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차전(車前)子의 약침(藥鍼) 및 경구투여(經口投與)가 백서(白鼠) 간손상(肝損傷)에 미치는 영향(影響)
권선호 ( Seon Ho Kwon ),김철홍 ( Cheol Hong Kim ),윤현민 ( Hyoun Min Youn ),장경전 ( Kyung Jeon Jang ),안창범 ( Chang Beolhm Ahn ),김훈 ( Hoon Kim ),송춘호 ( Choon Ho Song ) 대한경락경혈학회 2006 Korean Journal of Acupuncture Vol.23 No.2
Objectives: This study was undertaken to determine if Plantaginis Semen(PS) has a protective effect against CCl4 induced hepatoxicity in Rats. Methods: The experimental groups were divided into Normal group (untreated Group), Control group (group treated with CCl4), Sample 1 (group treated with 0.1 ml Plantaginis Semen herbal acupuncture in both sides of Ganshu (BL18) after CCl4 treating) and Sample 2 (group treated with feeding of 1 ㏄Plantaginis Semen extraction after CCl4 treating). Rats were administered orally CCl4 (0.1 ㎖/㎏) for 4 days. In experiments for PS effect, rats of Sample 1 group received 0.1ml herbal acupuncture of PS extraction in both sides of corresponding Ganshu (BL18) of human body for 3 days after treated CCl4. Rats of Sample 2 group feeded PS extraction (1㏄) for 3 days after treated CCl4. Variation of weight and biochemical assays (AST, ALT, LDH, ALP, total cholesterol, triglyceride, total protein, albumin) were performed. Results: In Control group, CCl4 increased serum AST, ALT, LDH, ALP, total protein, albumin and decreased weight, total cholesterol, triglyceride. Sample 1 and Sample 2 significantly decreased serum AST, ALT, LDH, ALP, total protein, albumin as compared with Control group. Conclusion: These results indicate that PS could be used in prevention and treatment of hepatoxicity. However, precise mechanisms of PS protection remain to be determined.