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호도약침액(胡桃藥鍼液)이 독성물질(毒性物質)에 의한 간조직(肝組織) 손상(損傷)에 미치는 영향(影響)
이경태 ( Kyung Tae Lee ),김철홍 ( Cheol Hong Kim ),윤현민 ( Hyoun Min Youn ),장경전 ( Kyung Jaen Jang ),안창범 ( Chang Behm Ahn ),송춘호 ( Choon Ho Song ) 대한경락경혈학회 2005 Korean Journal of Acupuncture Vol.22 No.1
Objectives: This study was carried out to determine whether Juglandis Semen herbal acupuncture (JSA) exerts the protective effect against toxic agent-induced liver cell damage. Methods: The cell damage was estimated by measuring lactate dehydrogenase (LDH) release, and lipid peroxidation was estimated by measuring malondialdehyde (MDA), a product of lipid peroxidation, in rabbit liver slices. Results: When tissues were incubated with 0.5 mM Hg for 10~120 min, LDH release and lipid peroxidation were increased as a function of incubation time, and these effects were significantly prevented by addition of 0.1 % JSA. Hg increased LDH release and lipid peroxidation in dose-dependent manner over the range of 0.1~1 mM concentrations, which were reduced by 0.1 % JSA. When tissues were treated with 0.5 mM Hg in the presence of 0.05~1 % JSA, LDH release and lipid peroxidation induced by Hg were prevented by JSA in a dose-dependent fashion. JSA at 0.5 and 1 % prevented completely effects of 0.5 mM Hg. When tissues were treated with 0.5 mM Hg for 60 min, LDH release and lipid peroxidation were increased, which were significantly prevented by addition of 0.1 % JSA. tert-Butyl hydroperoxide (tBHP) increased LDH release and lipid peroxidation, which were significantly reduced by 0.1 % JSA. Such protective effects were similar to those of N,N`-diphenylp-phenylenediamine (DPPD), a potent antioxidant. When tissues were treated with 0.5 mM Hg, activities of catalase and glutathione peroxidase were inhibited, and glutathione content was also reduced. Such effects were prevented by JSA, but not by DPPD. JSA prevented Hg-induced morphological changes. Conclusions: These results indicate that JSA exerts the protective effect against liver cell injury induced by toxic agents through antioxidant action, and this effect may be attributed to an increase in activities of endogeous anitoxidant enzymes and GSH content. However, antioxidant effect of JSA is different from that of a well-known potent antioxidant DPPD.
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