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- 저자 : 안영아(YoungAh Ahn) (검색결과 2 건)
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HPLC-MS/MS를 이용한 트리클로로에틸렌 대사산물의 다중 분석법 확립
안영아,고영림,이승호,신미연,전중대,김성균,Ahn, Youngah,Kho, Younglim,Lee, Seungho,Shin, Mi-Yeon,Jeon, Jung Dae,Kim, Sungkyoon 한국환경보건학회 2014 한국환경보건학회지 Vol.40 No.2
Objectives: We aimed to develop a measurement method of five metabolites of trichloroethylene (TCE) in a concurrent biological sample, e.g., trichloroacetic acid (TCA), dichloroacetic acid (DCA), S-(1,2-dichlorovinyl) glutathione (DCVG), S-(1,2-dichlorovinyl)-L-cysteine (DCVC), and N-Acetyl-S-(1,2-dichlorovinyl)-L-cysteine (NAcDCVC) and to validate the method before application to pharmacokinetic study. Methods: TCE metabolites were simultaneously analyzed using high performance liquid chromatography coupled with electrospray ionization mass spectrometry (HPLC-ESI-MS/MS) with as little as 50 ${\mu}L$ of serum and urine. DCA, TCA and NAcDCVC were extracted with diethyl ether, while DCVC and DCVG were extracted by solid phase extraction. This method was validated according to the guidelines for bioanalytical method validation of the Korean National Institute of Toxicological Research. Then, we determined the five metabolites in five strains of mice at 24 hr after exposure to 1 g TCE /kg body weight. Results: The limits of detection for the five metabolites in biological samples ranged from 0.001 to 0.076 nmol/mL, which is comparable to or better than those previously reported. Most calibration curves showed good linearity ($R^2=0.99$), and between-batch variation was less than 20% expressing acceptable robustness and reproducibility. Using this method, we found TCA and DCA were detected in all test mice at 24 hr after the oral administration while NAcDCVC and DCVC were detected in some strains, which showed strain-dependent metabolism of TCE. Conclusions: The present method could provide robust and accurate measurements of major key metabolites of TCE in biological media, which allowed concurrent analysis of TCE metabolism for limited amounts of biospecimens.
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SychCharts를 이용한 임베디드 시스템을 위한 RTOS Scheduling 검증
이수영(SuYoung Lee),안영아(YoungAh Ahn),김진현(JinHyun Kim),류갑상(GabSang Ryu),최진영(JinYoung Choi) 한국정보과학회 2004 한국정보과학회 학술발표논문집 Vol.31 No.1A
Mission-Critical한 실시간 반응형 내장 시스템들의 설계과정에 있어 high-level abstraction과 formal(software 기반) modeling은 없어서는 안될 중요한 부분이다. 실시간 반응형 내장 system의 OS는 정형 명세 기법을 이용하여 시스템의 주요 component들을 설계하고 OS의 Formal model들을 모든 가능한 input들 아래 OS의 behavior를 엄격하게 검증함으로써 error가 없는 완벽한 OS를 개발할 수 있다. 본 논문에서는 uC/OS-II의 OS Scheduling 부분을 반응형 시스템 언어인 Esterel의 SyncCharts로 명세, 명세한 시스템의 요구조건을 정형기법을 이용해서 검증해보고자 한다.
ScienceON
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