농포성 약진의 임상 및 병리조직학적 고찰

김수정(Soo Jung Kim),이승헌(Seung Hun Lee),안성구(Sung Ku Ahn),이원수(Won Soo Lee),이범주(Beom Joo Lee) 대한피부과학회 1994 大韓皮膚科學會誌 Vol.32 No.4

Background : Pustular eruptions due to drugs are uncommonly reported. We studied the characteristics of clinical and histopathologic findings of pustular drug eruption. Objective : We observed th.e causative agents, clinical featurs and histopathologic findings of pustular drug eruption and identified differential points of generlized pustular eruption. Methods : We evaluated t,he clinical and histopathologic findings of 8 patients with pustular drug eruption and reviewed the literatures reported cases of pustular drug eruption. Results : All patients diagnosed pustular drug eruption suffered from generalized pustular eruption associated with systemic symptoms such as fever, headachened myagia one to three days after treatment with causative agents. The causative agents of putular drug eruption are antibiotics such as ceftriaxone, analgesics and antipyretics. The pustule resolved after a few days of treatment with systemic corticosteroids and antihistamines. Laboratory findings revealed leukocytosis, neutrophilia, and analevated erythrocyte sedimentation rate, On histopatologic findings, we observed subcorneal pustuls containing neutrophils, eosinophils and some lymphocytes and spongiosis, exocytosis of acute iiflammatory cells. Perivascular infiltration of lymphocyte ancl edema of papillary dermis was also bserved in the dermis. Conclusion : Pustular drug eruption is characterized by generalized pustular eruption associated with systemic symptoms and histopathologic findings of that are sterile subcorneal pustules. Therefore differential diagnosis of other generalized pustular erupticns are relatively easy by careful history of medication, clinical and histopathologic findings. (Kor J Dermatol 1994; 32(4): 554-561)

원형 탈모증 환자에서 DPCP도포 부위에 발생한 백반증

김수정(Soo Jung Kim),이원수(Won Soo Lee),이승헌(Seung Hun Lee),안성구(Sung Ku Ahn) 대한피부과학회 1994 대한피부과학회지 Vol.32 No.5

Common adverse effects due to topical therapy with DPCP(Diphenyprone) are severe contact dermatitis, dermographism, urticaria, generalized pruritus, lymphadenoiathy, and dermatitis on the remote areas. Rarely, DPCP can induce vitiligo or dyschromia in confetias side effects on the pigmentary system. It is not clear yet whither DPCP induced the vitiligcbatoxic effect of phenol ring in DPCP or by koebner phenomenon clue to repeated contact dermatitis in cases where vitiligo was in latent subclinical condition. We describe a patient with alopecia areatairho developed vitiligo due to topical therapy with DPCP. A 20-year-old woman developed alopecia areata with a loss of eye shows and eyelashes. After sensitization, DPCP was topically applieid to the scalp every week. Vitiligo, confirmed by electron microscopic study, appeared 4 month. after the beginning of treatment and was localized only to the areas of topical application. Both alogecia aieata and vitiligo are improving now under systemic and topical corticosteroid therapy. (Kor J Dermatol 1994;32(5):934-938)

모발염색으로 인한 각피의 손상과 재생 : 시간 경과에 따른 형태학적 변화

김수정 ( Soo Jung Kim ),이원수 ( Won Soo Lee ),최응호 ( Eung Ho Choi ),안성구 ( Sung Ku Ahn ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.2

Background: The effects of external chemicals on the hair shaft are of great interest in both the medical field and the cosmetic industry. Current methods to analyze these effects consist mainly of macroscopic testing such as touch and tell little about the actual hair morphology. Object: The purpose of the present study was to evaluate the morphologic changes of hair shaft, especially cuticle, after aoplication of permanent dye. Methods : The coloring was performed as routine procedures. The time of contact of the dyeing solution within the scalp and hair was 30minutes. The coloring process ends with a through rinsing with water, Scanning electron microscopic findings of hair cuticle was observed sequentially before and after application of hair dye. Results : After 30minutes, cuticular swelling without degeneration was seen. As the swelling improve, the cuticular degradation was noted initially at 90minutes, By the 2 hours to the 1 week gradual progression of cuticular degradation was noted. By 1week after coioring, cortical exposure due to extensive cuticular detachment was observed. The reaction reached a peak between 1 and 2 weeks. Then, damaged outicles were gradually regenerated and returned to pre-treatment states by 8weeks. Conclusion : The hair fibers take l month to grow out by 1cm, at which point a fresh dye application becomes necessary. However, aithough the cuticles were regenerating, the cuticular damage still remained after 6 weeks. So, we concluded that interval of coloring is required more than 8 weeks. But further study to protect cuticle and to improve regeneration will be needed for shortening of regeneration time. (Kor J Dermatol 1996;34(2): 257-263)

A Herpes Simplex Virus Infection Secondary to Acupuncture and Cupping

Ye-Jin Jung,Jae-Hong Kim,Hae-jin Lee,Hana Bak,홍승필,Soo Young Jeon,안성구 대한피부과학회 2011 Annals of Dermatology Vol.23 No.1

Acupuncture and cupping have a public reputation as being safe even though these practices can lead to complications such as trauma or infection. We report here on a case of herpes simplex virus (HSV) infection secondary to acupuncture and cupping in a 56-year-old woman. The patient, who had a history of acupuncture and cupping on her left forearm for treating her myalgia, developed painful papules. Histologically, the biopsy specimen showed characteristic ballooning degeneration and inclusion bodies in the epidermis and mid-dermis. These clinical and histological findings were consistent with the diagnosis of HSV infection. (Ann Dermatol 23(1) 67∼69, 2011)

실험용 토끼에서 Calcium Gluconate의 혈관외 유출에 의한 시간별 조직변화에 관한 연구

김균태,김수정,이승헌,안성구,이원수 ( Kyun Tae Kim,Soo Jung Kim,Seung Hun Lee,Sung Ku Ahn,Won Soo Lee ) 대한피부과학회 1994 대한피부과학회지 Vol.32 No.4

Calcium gluconate 제재는 신생아 저칼슘증(neonate hypocalcemia)치료시 사용되는 대표적인 약물이다. 그러나 정맥내로 주시시 혈관밖으로 약물이 유출되는 경우 약 8%에서 급성 염증반응이나 피부괴사, 피부석회증 등의 피부 부작용이 발생하는 것으로 알려져 있다. 이러한 부작용은 특별한 치료없이 수개월내에 자연소실이 되기도 하지만, 이차적인 감염 및 심한 부종과 압통을 일으킬 수 있으며 광범위한 피부괴사와 함께 가피를 형성하기도 한다. 일단 피부괴사와 함께 가피가 형성되면 피부이식외에는 완전한 치료방법이 없고 또한 외부적으로 심각한 반흔을 남길수 있기 때문에 그 부작용이 매우 심각한다. 최근 국내에서 calcium chloride를 상완 정맥내로 주사중 혈관외로 유출되어 피부 석회증이 발생한 증례가 보고되고 있으며, 이런 부작용의 치료방법에 대해서는 얼음찜질과 같은 대중요법외에는 적절한 치료방법이 없는 것으로 보고되고 있다. 이에 저자들은 실험용 토끼에 10% calcium gluconate와 triamcinolone acetonide를 인위적으로 피하 지방층내에 주입시킨후 시간별 임상소견 및 조직학적 변화를 관찰하고, 피부반응의 발생기전 및 적절한 치료, 예후 등에 관하여 알아 보고자 한다. Background:Neonatal hypocalcemia is not an infrequent condition, especially in the premature neonate. It is effectively treated by intravenous administration of calcium gluconate. Complications of extravasation during intraveous infusion included localized calcification arid, occasionally necrosis. But the exact mechanism of calcinosis cutis following extravasation of calcium gluconate remains unknown and there is no specific mode of treatment except cold packs and skin graft. Objective:Our purpose was to evaluate the clinical and histological features in rabbits after subcutaneous injection of 10% calcium gluconate and a mixed solution of calcium gluconate and triamcinolone acetonide. Methods:Two rabbits were divided into 3 groups and were subcutaneously injected with the following materials on the back;10% calcium gluconate, a mixed solution of calcium gluconate and triamcinolone acetonide, and 25% normal saline as controls respectively. The injection site including the skin and subcutaneous fat was excised and fixed with natural buffered formalin. The biopsied specimens were stained with Hematolxylin and Eosin. Results: 1. In the 10% calcium gluconate injected group, there was some erthema and induration after three days. By the fifth to the seventh days there was more erythema and arm induration. At 15days, nodules and large ulcerated lesions developed. Multiple linear shaped, ulcerative surfaced and indurated masses were noted at 37days. From 45days to 2months there was progressive healing with decrease in ulceration, and gradual disappearance of the mass. Histologically, at the 8th day calcium was seen in the walls of the arteries and veins. After 15days, calcium deposition and granuloma formation were ween in the dermis. In addition discharge of calcium deposits began to take place by means of transepidermal elimination. After 45days, although the response was subsiding, the calcium and mucin deposition was observed focally in the dermis. 2. In the 10% calcium gauconate and triamcinolone acetonide adjuvant injected group, there was development of some erythema at 8days. After 15days, the injection site was normal in appearance. Histologically, at 15days calcium deposition was seen on the upper ?ermis and the injection site was histologically normal after one month. 3. In the 25% normal saline injected group, the injection site was clinically normal. Histologically there was no reaction except for focal perivascular eosinophilia after 24hours. Conclusion:We conclude that the important mechanism of calcinosis cutis appears to be elevated concentration as well as the tissue damage at the site of the extravasation of calcium gauconate. The final common pathway of calcification is the formation of crystalline and insoluble calcium phosphate mineral, in the form of hydroxyapatite. The intralesional injection o’triamcinolone acetonide for the treatment of calcinosis cuts in our study was effective due to its antimflammatory effect and the reabsorption of calcium in the tissue.(Kor J Dermatol 1994;32(4):574~582)

건성피부 및 소양증에 대한 잘스밍R 크림의 임상효과에 대한 연구

김수정,이인욱,최응호,이원수,안성구 ( Soo Jung Kim,In Wook Lee,Eung Ho Choi,Won Soo Lee,Sung Ku Ahn ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.3

Background: Xerosis is a relatively common disorder, especially in the elderly. The condition is characterized by fine scaling and is associated with generalized pruritus. Objective : The purpose of this study was to evaluate the clinical efficacy, safety and tolerability of Zalsming cream in patients with xerosis and pruritus. Methods : Thirty patients were treated with Zalsming cream. Clinical efficacy, as measured by the score of subjective symptom and objective signs, transepidermal water loss(TEWL) and electron microscopic finding, were asessed at 2, 4, and 6 weeks after topical application of the cream. Results . The scores of clinical signs and TEWL showed statistically significant improvements. No one developed any local or systemic side effects. Conclusion : Topical application of Zalsming cream was found to be effective and safe for patients suffering from xerosis and pruritus. (Kor J Dermatol 1997;35(3): 418-423)

궤양성 대장염이 동반된 결절홍반

이인욱 ( In Wook Lee ),김수정 ( Soo Jung Kim ),안성구 ( Sung Ku Ahn ),이원수 ( Won Soo Lee ),최응호 ( Eung Ho Choi ),윤경한 ( Kyeong Han Yoon ) 대한피부과학회 1995 대한피부과학회지 Vol.33 No.6

We report a case of erythema nodosurn associated with ulcerative colitis which occurred in a 13-year-old girl who showed well demarcated, painful, erythematous nodules and plaques on both upper and lower extremities. The patient also experienced frequent intermittent abdominal pain and bloody stools for about 1 year. Laboratory findings revealed polymorphonuclear leukocytosis and occult blood in the stool. Findings of sigmoidoscopy, barium enema, and rectal biopsy were consistent. with ulcerative colitis. A skin biopsy from the lesion on the right shin revealed a moderate inflammatory cell infiltrate in the septa of the subcutaneous fat layer, composed chiefly of lymphohistiocytes and a few epitheloid cells. The symptoms and signs responded well to orally administered prednisolone and sulfasalazine. (Kor J Dermatol 1995;33(6): 1164-1167)

얼굴에 재발하는 홍반을 주소로 내원한 환자에서 첩포검사의 중요성

구자웅 ( Ja Woong Goo ),김민정 ( Min Jung Kim ),이원수 ( Won Soo Lee ),안성구 ( Sung Ku Ahn ),최응호 ( Eung Ho Choi ) 대한피부과학회 2006 大韓皮膚科學會誌 Vol.44 No.4

Ethyl Carbamate의 그 대산 산물의 피부종양 유발에 관한 비교 연구

안성구,김수정,원진형,최응호,홍성노 연세대학교 원주의과대학 1995 원주의대논문집 Vol.8 No.1