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RISS 인기검색어
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- 저자 : 안선영 ( Sun Young Ann ) (검색결과 2 건)
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단일 3차 의료기관에 내원한 탈북자 환자들의 임상적 특징
안선영 ( Sun Young Ann ),류성혁 ( Sung Hyeok Ryou ),김석배 ( Suk Bae Kim ) 대한내과학회 2015 대한내과학회지 Vol.89 No.1
Background/Aims: There are increasing numbers of North Korean defectors, and their health status differs from that of the South Korean population. This study was performed to investigate the clinical characteristics of North Korean defectors visiting a single tertiary hospital in South Korea. Methods: The medical records of North Korean defectors who visited Dankook University Hospital, Cheonan, South Korea from 1 February 2006 to 30 April 2014 were retrospectively reviewed. Their comorbidities, main reasons for the visit, and most common diseases were investigated. Results: A total of 169 North Korean defectors (163 females, 6 males) visited our hospital. Sixty-eight patients (40.24%) had comorbidities, the most common of which was tuberculosis (13.60%), followed by chronic hepatitis B (10.06%) and chronic hepatitis C (9.47%). North Korean refugees visited the department of ophthalmology (15.71%) most frequently, followed by gastroenterology (15.18%). Cataracts, chronic hepatitis C, chronic hepatitis B, and pulmonary tuberculosis were the most common reasons for the hospital visit. Chronic hepatitis B and chronic hepatitis C were diagnosed in 19.32% and 17.58% of the patients, respectively. Sixteen patients (9.47%) were diagnosed with tuberculosis, and eight of these patients showed multidrug resistance. Of all 169 patients, 17 underwent colonofibroscopy or stool examination, and parasites (Trichuris trichiura, n = 6; Clonorchis sinensis, n = 1) were found in 7 patients (41.18%). Conclusions: Most North Korean defectors who visited this tertiary hospital in South Korea were female, and they mainly visited the departments of ophthalmology, gastroenterology, and pulmonology. Compared with South Koreans, they showed high rates of chronic hepatitis B, chronic hepatitis C, pulmonary tuberculosis with multidrug resistance, and parasite infection. (Korean J Med 2015;89:54-63)
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Tumor necrosis factor-alpha-308G/A의 유전적 다형성과 항결핵제 유발 반구진발진과의 연관성
서원용 ( Won Yong Suh ),김요한 ( Yo Han Kim ),주현돈 ( Hyun Don Joo ),박성준 ( Seong Jun Park ),류성혁 ( Sung Hyeok Ryuo ),최지성 ( Ji Sung Choi ),안선영 ( Sun Young Ann ),박창현 ( Chang Hyun Park ),김상훈 ( Sang Hoon Kim ),김상헌 대한천식알레르기학회 2015 Allergy Asthma & Respiratory Disease Vol.3 No.2
Purpose: Adverse cutaneous reactions to antituberculous drugs (ATD), such as maculopapular eruption (MPE), are the most com￢mon causes of discontinuation of scheduled treatment of tuberculosis. We previously reported that tumor necrosis factor (TNF)-α genetic polymorphism -308G/A is significantly associated with ATD-induced hepatitis. This study aimed to investigate associations between TNF-α -308G/A and ATD-induced MPE. Methods: Patients with ATD-induced MPE and controls without any adverse reactions to ATD were recruited from the database of the Adverse Drug Reaction Pharmacogenomic Research Group database of Korea. We compared the genotype frequency of TNF-α -308G/A between patients with ATD-induced MPE and ATD-tolerant controls. Results: A total of 69 patients with ATD-induced MPE and 229 control subjects were enrolled for this study. There were no significant differences in genotype frequency between the patients and the controls, suggesting lack of associations between TNF-α -308G/A and ATD-induced MPE. Conclusion: The TNF-α genetic polymorphism -308G/A may not be related to the development of ATD-induced MPE, in contrast to ATD-induced hepatitis. These findings suggest that associations between TNF-α -308G/A and ATD-induced adverse reactions can be phenotype-specific.(Allergy Asthma Respir Dis 2015;3:124-127)
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