영선제통음이 진통 및 소염작용에 미치는 영향

안덕균(Dug-Kyun Ahn) 한국생약학회 1981 생약학회지 Vol.12 No.1

The results of the comparison among the effects of decoction, extract powder and Gamiyoungsunjetongeum are as follows: In the experiment of analgesic effect in rats, having pain caused by Acetic acid, decoction showed a considerable reduction; extract powder did not show any notability and the effect of added decoction was conspicuous. The Anti-inflammatory effect of decoction was notable during 90∼240minutes, but extract powder also did not show any notability and added decoction showed a remarkable effect. In the experiment of inhibition on heat denaturation of serum rats, decoction and extract powder showed the inhibiting effects of 18.2%, 17.9% and the added decoction was even more remarkable (28.3%).

상용 한약재의 부작용에 관한 연구

안덕균(Dug-Kyun Ahn),김찬수(Chan-Soo Kim) 한국생약학회 1983 생약학회지 Vol.14 No.3

As many crude drugs are used in the oriental medical field problems on the side effects of these drugs come to the front. To conduct delayed-type hypersensitivity we selected 29 kinds of drugs used frequently for therapeutic agents in oriental medical hospitals (Table I). The cell-mediated immune response was evaluated by measuring the foot pad swelling reaction and humoral immune response by measuring the antibody formation to these crude drugs. Mice were given these drugs intraperioneally for sensitization and challenged with same drug as used for sensitization respectively by intral dermal injection on the left and righ hind foot pad 4 days after senstization and then the foot pads were measured with the dial micrometer. The results were as follow; 1) Gentianae Scabrae Radix, Arecae Semen, Corydalis Tuber, and Paeoniae Radix were significant as delayed-type hypersensitivity inducers. 2) None of the crude drugs tested had effect on the induction of humoral immune response.

상백피의 본초서지학적 분석

안덕균(Dug-Kyun Ahn),류경수(Kyung-Soo Ryu) 한국생약학회 1981 생약학회지 Vol.12 No.1

Bibiliographically analyzed in the herbological way the drugs combinated with Mori Cortex Radicis and their active principles among the prescriptions in the Dong-Ui-Bo-Gan, (東醫寶鑑) of our country. Numerous names of botanical origin were described, but it was not recorded that San-Keun-Baik-Pi old days is different from root bark of Morus sp. in this times. The chiefly cured symptoms with Mori Cortex Radicis were constantly not different from the contents of Shin-Nong-Bon-Chao-Kyung in ancient times, but it has bean developed since Ming dynasty. Its uses are widely extended to a surgical and dermatologic decease; rheumatic, beriberi and diabetes in this times, and itsefficacies depend upon curing. Prescriptions on Mori Cortex Radicis that were prescribed in Dong-Ui-Bo-Gam are there, 177 combinated with it Glycyrrhizae Radix is most frequently combinated with Mori Cortex Radix (frequently 68%). It is proved that Armeniacae Semen, Platycodi Radix ete, in the order take strong effects on antitussive, antiphlogistic, diuretic, antipyretic etc. As the above prescriptions are classified, respiratory tract decease is most frequently in 69 prescriptions, the next gastrointestinal tract 13 times, diuretic 13 times, diuretic 12 times, and antipyretic 11 times. Therefore, Mori Cortex Radicis contains a good remedial value chiefly of the effects upon the respiratory. diseases.

하고초산이 Thioacetamide에 의한 백서 간손상에 미치는 영향

이영종(Young-Jong Lee),안덕균(Dug-Kyun Ahn) 한국생약학회 1983 생약학회지 Vol.14 No.1

To experimentally research out the effect of Hagocho-San used for liver disease on the clinical treatment of oriental medicine, I induced liver damage rats by thioacetamide and dosed the extracts orally and measured the activity rate of GOT, GPT, ALP and LDH. The following results were obtained: 1) GOT activity was more decreased in the experimental group than in the control group. Extracts from mixed decoction was more efficacious than those mixed form of the extracts after individual decoction. Extracts from decoction showed continuous significance after 48 hours on, but mixed form of extracts after individual decoction was significant only after 48 hours and 96 hours. 2) GPT activity was more decreased in the experimental group than in the control group. Extracts from mixed decoction was effective after 48 hours on but mixed form of extracts after individual decoction was significant after 48 hours and 72 hours. 3) ALP activity was more decreased in the experimental group than in the control group. Extracts from mixed decoction was more efficacious than the mixed form of extracts after individual decoction and significance was verified after 72 hours on. 4) The significance of LDH activity in the extracts from mixed decoction was rovealed after 72 hours and 96 hours but mixed form of extracts after individual decoction showed significance 72 hours later. 5) From the above results, it was showed that Hagocho-San extract was effective on liver disease and extracts from mixed decoction was more effective than mixed form of extracts after individual decoction.

상백피에 관한 연구 (Ⅰ) : 상백피의 본초서지학적 분석

류경수(Kyung-soo Ryu),안덕균(Dug-Kyun Ahn) 한국생약학회 1980 생약학회지 Vol.11 No.2

In this paper, we studied what the drug name of Sang-Baik-Pi (桑白皮 Mori Cortex Radicis) is, how to collect it; and how the chief symptoms had changed in the Chinese medical references and herbological literatures and formularies. Also we bibliographically analyzed in the herbological way the drugs combinated with Sang-Baik-Pi and their active principles among the prescriptions in the famous medical book; Doug-Ui-Bo-Gan, (東醫寶鑑) of our country. Finally, we concluded as follow. Numerous names of botainical origin were described, but it was not recorded that San-Keun-Baik-Pi (桑根白皮) in old days is different from root bark of Morus sp. in this times. Sang-Baik-Pi has been a common designation since Ming dynasty (AD 1500). Collections of it were independent of seasons, it could effect perfectly over 10 years old. And its cork layer should be removed after collections, it was especially emphacised that root bark an ground was poisonous. The chiefly cured symptoms with Sang-Baik-Pi were constantly not different from the contents of Shin-Nong-Bon-Chau-Kyung (神農本草經) in ancient times, but it has been developed since Ming dynasty. Its uses are widely extended to a surgical and dermatologic decease; rheumatic, beriberi and diabetes in this times, and its efficacies depend upon curing. Prescriptions on Sang-Baik-Pi that were prescribed in Dong-Ui-Bo-Gam are there, 177 drugs combinated with it. Glycyrrhizae Radix is most frequently combinated with Sang-Baik-Pi(frequently 68%). It is proved that Armeniacae Semen, Platycodi Radix etc, in the order take strong effects on anti-tussive, anti-phlogistic, diuretic, anti-pyretic etc. It is expressed 34 times, frequently, that a dose is 3.75g, and it shows that a usual does is 2-4g. As the above prescriptions are classified, the results is as follows, respiratory tract decease is most frequently in 69 prescriptions, the next gastrointestinal tract 13 times, diuretic 12 times, and antypyretic 11 times. Therefore, Sang-Baik-Pi contains a good remedial value chiefly of the effects upon the respiratory diseases.

평위지유탕이 생쥐 혈장 Prothrombin시간에 미치는 영향

김원대(Won-Dae Kim),안덕균(Dug-Kyun Ahn) 한국생약학회 1983 생약학회지 Vol.14 No.4

To explain the medical effect of Pyungwijiyu-Tang which is mostly used in excremental blood caused by Eum-Gyul(陰結) in oriental medicine. The plasma prothrombin time on mouse dosed Pyungwijiyu-Tang, Gami-Pyungijiyu-Tang and Schizonepetae Herba (parched) were revealed the shorten effect, but the plasma prothrombin time on mouse dosed Zingiberis Rhizoma (parched) was not revealed the shorten effect.

하고초산이 Thioacetamide에 의한 백서간손상에 미치는 영향

이영종(Young-Jong Lee),안덕균(Dug-Kyun Ahn) 한국생약학회 1982 생약학회지 Vol.13 No.4

夏枯草散은 東醫寶鑑 等에 수록되어 있는 生藥複合劑로서 夏枯草·杏附子·甘草로 구성되어져 있고, 東醫臨床에서 肝虛로 因한 目晴疼·冷漏不止·筋맥疼 等症에 사용되고 있다. 이에 演者들은 夏枯草散의 효능을 실험적으로 究明하기 위해서 白鼠에 Thioacetamide를 投與하여 肝損傷을 유발시킨 다음 夏枯草散 엑기스 劑를 經口投與한 後 血淸中 GOT, GPT, ALP 및 LDH의 活性度를 측정하였다. 그 結果 實驗群이 對照群에 比하여 GOT, GPT, ALP 및 LDH의 活性度가 모두 현저히 감소되는 경향을 나타내어 夏枯草散이 肝疾患에 有意한 治療效果가 있음을 알수 있었다.

[화학] 황련 중 berberine의 추출효율에 관한 연구

이재성(Jae Seong Rhee),박호군(Ho Koon Park),우은란(Eun Ran Woo),이은주(Eun Ju Lee),안덕균(Dug Kyun Ahn),윤원식(Won Sik Youn),신광호(Kwang Ho Shin) 한국분석과학회 1997 분석과학 Vol.10 No.2