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Recombinant human bone morphogenetic protein-2와 anorganic bovine bone 혼합이식 후치유과정에 관한 실험적 연구
안교진 ( Kyo Jin Ahn ),박주철 ( Zju Cheol Park ),김영균 ( Young Kyun Kim ) 조선대학교 치의학연구원 2014 Oral Biology Research (Oral Biol Res) Vol.38 No.2
Purpose: The purpose of this study was to evaluate a bone healing procedure using anorganic bovine bone and recombinant human bone morphogenetic protein-2 (rhBMP-2). Materials and Methods: Anorganic bovine bone (Bio-Oss®; Geistlich Pharma AG, Wolhausen, Switzerland) was grafted at two preformed alveolar bone defects in beagle dogs. One was filled only with Bio-Oss® while the other was filled with Bio-Oss® mixed with rhBMP-2. Both animals were sacrificed at 2, 4, and 8 weeks after the experiment. Block specimens, including grafted bone and surrounding bone, were harvested and histological healing procedure evaluated. Results: Increased strength and radiopacity were observed in both groups in a time-dependent manner. However, when using rhBMP-2 together, more new and matured bone was formed histologically. Conclusion: In this study, we showed that rhBMP-2 can promote bone formation effectively, and anorganic bovine bone can be used as a scaffold.