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RISS 인기검색어
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- 저자 : 심영은(Yeong Eun Sim) (검색결과 2 건)
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알코올의존증 치료약물 복용 여부 모니터링을 위한 소변 중 크레아티닌 농도로 보정된 날트렉손 및 6β-날트렉솔 측정값 평가
심영은(Yeong Eun Sim),김선영(Seon Yeong Kim),정재철(Jae Chul Cheong),이현수(Hyun Soo Lee),표재성(Jaesung Pyo),김진영(Jin Young Kim) 대한약학회 2022 약학회지 Vol.66 No.2
This study aimed to detect naltrexone (NTX) and its metabolite 6β-naltrexol (6βNTX) in the urine samples of parolees or probationers who were legally bound to participate in an alcohol dependence treatment program to determine whether to follow the medical treatment ordered by the court. The developed liquid chromatography-tandem mass spectrometry method was suitable for the simultaneous detection of NTX as well as its active metabolite 6βNTX in urine samples. The ratio of creatinine to the analyte ([analyte, ng/mL]/[creatinine, mg/dL]) was used to exclude inaccuracies caused by urine dilution, and this value was further corrected by the average urine creatinine concentration in Korean adults (male 132.6 mg/dL, female 93.3 mg/dL). The cut-off values for NTX and 6βNTX were set at 10 ng/mL. If both the parent drug and its metabolite were found in urine and the corrected creatinine concentrations of NTX and 6βNTX were more than 10 ng/mL, it was considered that the participants were following their treatment protocol accordingly. The results showed that 81 (94.2%, male 69 and female 12) of 86 participants were taking NTX, whereas five (four males, one female) were not adhering to the protocol accordingly. It was found that the four male participants (4.9%) of the 81 participants who were taking the drug initially had urinary NTX and 6βNTX concentrations below the cut-off level without correcting creatinine level, but the values met the acceptance criteria (i.e., >10 ng/mL) of the medical treatment program after correcting the creatinine level. The proposed method can be applied to other drugs in the future.
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소변 시료 중 메스암페타민 및 암페타민 광학이성질체 농도 측정 결과의 불확도 평가
김진영(Jin Young Kim),심영은(Yeong Eun Sim),고범준(Beom Jun Ko) 대한약학회 2019 약학회지 Vol.63 No.6
The objective of this study was to assess the measurement uncertainty for determination of methamphetamine and amphetamine enantiomers in urine sample by liquid chromatography-tandem mass spectrometry (LC-MS/MS). The deuterium-labeled compounds were prepared for use as internal standards to quantify the analytes. Urine sample (200 μl) was diluted with pure water before the solid phase extraction (SPE). The sample was extracted and purified using Oasis HLB SPE cartridge followed by chromatographic separation on a vancomycin-based chiral column (150 mm×2.1 mm, 5 μm). The mass spectrometric analysis were performed in multiple reactions monitoring (MRM) selecting three precursor/ fragment ion pairs for each analyte. The potential sources that contribute uncertainty to the final result were evaluated. The major contributing factors impacting the combined standard uncertainty were calibration curve and repeatability, while the preparation of standard solution and sample dilution were minor factors. Relative expanded uncertainty of the measured analyte concentration was within 8.5% in a forensic urine sample.
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