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이종곤(Jong Kon Lee),이병삼(Byung Sam Lee),신옥식(Ok Shick Shin),신규창(Kyu Chang Shin),오용구(Yong Ky Oh),기세길(Se Gil Ki) 대한내과학회 1991 대한내과학회지 Vol.41 No.4
N/A Tsutsugamushi disease is an acute febrile disease which is characterized by fever, headache, rash, and eschar. In Korea, there has been an increasing concern over rickettsiosis since Tsutsugamushi disease among Koreans was first reported in 1986. We experienced 75 cases of Tsutsugamushi disease that occurred during the periods of October-November, 1989, 1990. They which were confirmed by indirect immunofluorecent antibody test and their clinical findings were analized. Of 75 cases, 28 were males and 47 were females. The mean age was 50 years. The main symptoms and signs were headache, myalgia, fever, rash, and eschar. Characteristic laboratory findings included hypoalbuminemia, elevation of SGOT, proteinuria and interstitial pneumonia on chest X-ray. The mean duration of defervescence of fever was l. 4 days with tetracycline therapy and 1,25 days with chloramphenicol therapy. All cases improved and there were no recurrences.
β-Lactamase의 억제제가 β-Lactam계 항생제에 대한 항균효과 증진에 관하여
신창재,신규창 대한감염학회 1989 감염 Vol.21 No.1
Both amoxillin-clavulanic acid and ampicillin-sulbactam inhibitor combinations exhibited pronounced synergistic bacteriostatic and bacteriocidal effects compared to single drug on staphylococcus aureus and shigella flexneri which from β-lactamase and resistant to β-lactams. But methicillin and other β-lactam resistant staphylococcus formed no β-lactamase except one strain, and enzyme inhibitors showed no synergistic effects of these methicillin resistant strains. On the other hand, all salmonella species tested were β-lactamase negative and inhibitors worked rather antagonstic against some strains combined with β-lactams.
신옥식,신규창,이병삼,장재권,정홍수,정태호,조용근,오용구 대한내과학회 1993 대한내과학회지 Vol.44 No.6
음주력이나 담도 질환없이 15년동안 반복적인 췌장염을 앓아온 45세 남자 환자에서 특별한 원인을 찾을 수 없는 심한 고지질혈증 특히 중성 지방의 현저한 증가를 관찰하였고, 체중 감량, 저지방식, 투약 등으로 중성 지방의 감소와 더불어 증상의 호전을 보인 예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. For a long time, it is well known that hyperlipidemia and pancretitis is closely related, though we could not define clearly whether the lipid abnormalities are the cause or the result of the pancreatitis. In patients with hyperlipidemia and pancreatitis, the recurrent bouts of pancreatitis are controlled only when serum triglyceride levels are lowered toward normal. A 45-year old man with abdominal pain due to pancreatitis was admitted. For 15 years, he had frequent relapse of pancreatitis. He denied any history of alcohol ingestion. On routine laboratory examination, we could find no abnormal finding except lactescent serum with marked hypertriglyceridemia up to 35 mmol/L, hypercholesterolemia and increased serum amylase level. With low fat diet, weight reduction and gemfibrozil 1,200㎎/day, he is now pain free and his serum triglyceride level is about 5.3 mmol/L (465㎎/dL).
Cogulase Negative Staplylococcis의 β-Lactam제에 대한 내성 및 β-Lactamase 억제재의 효과에 관하여
최종률,신규창,김성광 대한감염학회 1989 감염 Vol.21 No.3
The in vitro susceptibility tests of coagulase-negative staphylococci to β-lactam antibiotics were performed and the effects of β-lactamse inhibitors were evaluated. Among 88 strains, 38 strains (43.2%) were methicillin resistant ranging from 4 to 256mcg/ml, and ratios of resistant strains were 80.7, 77.0, and 58.0% respectively against amoxicillin, pencillin and ampicillin, but they were less than 10.0% to ecphalothin, cefazolin, ampicillin plus sulbactam and amoxicillin plus clavulanic acid, except 21.6% to ceftizoxime. There were strong resistance relation between methicillin and ampicillin or amoxicillin but weak relationship between methicillin and cephalosporins existed. Among methicillin reistant strains, some exhibited unresponse by sulbactam more often than clavulanic acid, but some β-lactamase negative strain showed response by enzyme inhibiotrs and few ampicillin or amoxicillin resistant strains showed neither response by inhibitors nor β-lactamase formation.