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임성우 ( Im Seong U ),이원익 ( Lee Won Ig ),한혜숙 ( Han Hye Sug ),한지숙 ( Han Ji Sug ),김민옥 ( Kim Min Og ),권순길 ( Kwon Sun Gil ),김혜영 ( Kim Hye Yeong ),신경섭 ( Sin Gyeong Seob ) 대한신장학회 2004 Kidney Research and Clinical Practice Vol.23 No.3
Paraquat intoxication is a fatal problem. Most of paraquat intoxications happen through oral administration. But there is no clinical data for parenteral paraquat intoxication, so we will describe its fatal progression and clinical course. A 52-year-old male injected paraquat solution on his thigh. Initial serum level of paraquat was 42.7 ug/mL and urgent hemoperfusion was performed and his serum level of paraquat was reduced by 5.2 ug/mL. But the patient expired due to respiratory failure and hypoxemia. Different from oral paraquat poisoning, serum level of the drug increases rapidly in intramuscular intoxication. So the paraquat in blood rapidly accumulates in tissue, especially lung parenchyme. We removed his paraquat in blood rapidly, but could not get rid of tissue concentration, so we lost him even with lowered serum paraquat level. Through this case, it is thought that the paraquat intoxication via intramuscular injection can make up a extremely poor prognosis even with very a little amount of paraquat. (Korean J Nephrol 2004;23(3):505-508)