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강준구,박상호,송현곤,정찬영,김호성,박영진,오현관 朝鮮大學校 醫學硏究所 1982 The Medical Journal of Chosun University Vol.7 No.-
A study was performed for detection of paraquat toxicity in rabbit which ingested 24.5% paraquat solution 120㎎/㎏ by gavage feeding. The results were as follows. 1. At autopsy finding, the majority of lung showed occasional small infiltrates of lymphocyte and plasma cell, accompanied by focal and minimal alveolar lining cell hyperplasis and collections of alveolar macrophages. But there were hemorrhage and edema, pulmonary fibrosis in a few cases. In liver, the midzonal and periportal fatty change were revealed at 3rd day. 2. Arterial blood gas analysis were revealed hypoxia and hypocapnea at early stage, but hypoxia and respiratory acidosis at late stage. The liver functionsua test were slightly increased at 5th day after pretreating with paraquat solution.
정상인 및 간질환에서의 혈청 Lipoprotein에 관한 연구
정찬영,이태웅,양효구,송현곤 朝鮮大學校 醫學硏究所 1982 The Medical Journal of Chosun University Vol.7 No.-
Serum lipoprotein patterns were studied in 66 normal persons and 64 patients with acute hepatitis and in 57 patients with cirrhosis of liver at Asan Foundation Attached Hospital from 1980 to 1981. Serum lipoprotein were seperated by electrophoresis with agarose gel and the following results were obtained. 1. In normal Korean, serum α-lipoprotein showed decrements with aging, while serum β-lipoprotein and pre-β-lipoprotein increased with aging, but the difference was not statistically significant. Significant alteration by sex in serum lipoprotein patternswere not observed. 2. Serum α and pre β-lipoprotein in patients with acute hepatitis gave lower value than in the normal persons, but the value of serum β-lipoprotein were significantly elevated. Sex and age difference showed no statical significance in this disease. 3. The value of serum α-lipoprotein fraction in patients with acute viral hepatitis B gave higher value than non-B acute viral hepatitis, but the difference was not statically significant. 4. Serum α and pre-β-lipoprotein fraction in patients with icteric hepatitis showed decrement with increasing of serum total bilirubin level. 5. In the patients with cirrhosis of liver, the value of α-lipoprotein was lower than normal subjects and patients with acute hepatitis, but (serum β-lipoprotein fraction was higher than normal subjects and patients with acute hepatitis. 6. Serum α-ilpoprotein fraction in patients with chronic hepatic encephalopathy was significantly lower then patients with cirrhosis of liver, but markedly higher value of serum β-lipoprotein than cirrhosis of liver was observed.