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Hitachi 7600 p-모률을 이용한 유리형경쇄 정량검사의 항원과잉역 반응
차경호 ( Kyong Ho Cha ),김승희 ( Sung Hεe Kim ),송창은 ( Chang Un Song ),심양보 ( Yang Bo Sim ),채효진 ( Hyo Jin Chae ) 대한임상검사과학회 2009 대한임상검사과학회지(KJCLS) Vol.41 No.4
The analysis of serum free light chains (sFLCs) can improve the diagnosis and monitoring of multiple myeloma and other plasma cell dyscrasias. As with other immunoassays, sFLCstests are subject to potential antigen excess and heterophilic antibody interference. We describe 9 cases of sFLCs antigen excεss in patients with multiple myeloma using the FreeliteTM Human Kappa and Lambda Frεe Kits (Thε Binding Site ltd., Birmingham, UK) and the Hitachi7600 P module turbidimetric system. A total of 1,247 consecutive samples from 250 patients with multiple myeloma were assayed for sFLCs from April to September, 2009. The samples were assayed using an initial dilution of 1 :5and subsequent dilutions of 1 :50 and 1: 100. The same samples were analyzed for the presence of monoclonal gammopathies using serum protεin electrophoresis (SPE) and immunofixation electrophoresis (IFE). There were 9 samples (0.72%) of antigεn excess with 3 cases of kappa (0.24%) and 6 cases of lambda (0.48%). Thεse cases reprεsents an example of antigen excess or " hook effect" using the sεrum free light chain assays and mandates high level of attεntion to falsely low sFLC 1εvels due to antigen excess, especially when it is disaccordant to other assay rεsults or c1inical manifestations.