음낭에 발생한 고립성 표피융해성 극세포종

손인범(In Bum Sohn),황상민(Sang Min Hwang),최응호(Eung Ho Choi),이원수(Won Soo Lee),송동훈(Dong Hoon Song),안성구(Sung Ku Ahn) 대한피부과학회 2000 대한피부과학회지 Vol.38 No.5

Isolated epidermolytic acanthoma (IEA) is a rare acquired benign tumor that presents as verrucous or papillomatous papule less than 1 cm in diameter. It does not have a characteristic clinical appearance or location and occasionally, several lesions are seen in a localized area. Histologically, it is characterized by epidermolytic hyperkeratosis, also referred to as granular degeneration. We present a case of 35 year-old male who had several lesions of epidermolytic acanthomas localized on the scrotum in the absence of any symptom. (Korean J Dermatol 2000;38(5):643~645)

오타모반의 임상 및 병리조직학적 검색 -대한피부과학회 피부병리 연구분과위원회 공동연구-

천승현 ( Seung Hyun Chun ),이상훈 ( Sanghoon Lee ),박하나 ( Hana Park ),전수영 ( Su Young Jhun ),손인범 ( In-Bum Sohn ),김학용 ( Hak Yong Kim ),최응호 ( Eung Ho Choi ),황상민 ( Sang Min Hwang ),이승헌 ( Seung Hun Lee ),김중기 ( Jo 대한피부과학회 2004 대한피부과학회지 Vol.42 No.3

Background: Ota`s nevus, characterized by the presence of melanocytes in the dermis, has been familiar among dermatologists, but the etiology, the pathophysiology, the clinical and histological classification are not entirely clear. To understand and elucidate them, more clinical studies and researches are necessary. Object: The aim of this study was to document the clinical and histopathological features of Ota`s nevus. Methods: We examined 299 patients with Ota`s nevus who visited the dermatology clinic in Korea from February 1993 to August 2003. Among them, 188 patients were biopsied. All the specimens were stained with hematoxylin and eosin. We examined the age & sex distribution, age of onset, seasonal variation, associated skin diseases, aggravating factors and color. We clinically classified Ota`s nevus into 4 types according to Tanino`s classification and histologically into 5 types based on the pattern of pigmentation. Results: 1. The ratio of male and female was 1:3. 2. The peak age of onset was at birth (28.4%) and puberty (24.8%). 3. Seasonal variation was observed with distinct aggravation in the summer (60%). 4. The associated diseases were 9 cases of persistent mongolian spot, 6 cases of nevus flameus, 4 cases of blue nevus, 3 cases of vitiligo, 3 cases of mevus of Ito, 2 cases of atopic dermatitis, 2 cases of psoriasis, 2 cases of cafe au late macules and 2 cases of contact dermatitis. 5. The aggravating factors were sunlight (35.8%), emotional stress (21.0%), menstruation (12.6%), cold exposure (9.5%), pregnancy (9.5%), fatigue (9.5%) and chemical agents (2.1%). 6. The color of lesions were blue black (36.8%), brown (34.8%), dark brown (16.1%) and slate (11.0%). 7. All cases were classified according to Tanino`s methods: type Ia (23.1%), type Ⅰb (20.1%), type Ⅱ (26.7%), type Ⅲ (9.4%), type Ⅳ (20.7%). 8. The histological subtypes of Ota`s nevus were classified as: the superficial type (35.6%); the middermis type (5.9%), the superficial-middermis type (18.6%); the mid-lower dermis type (2.7%); the diffuse type was composed of the superficial dominant type (19.7%), the middermis dominant type (4.8%), the dispersed (true diffuse) type (12.2%) and the deep dominant type (0.5%). 9. In the relation between histological types and the color of the lesion: the superficial type had 31 cases of brown color, 15 cases of blue black color, 11 cases of dark brown color and 9 cases of slate color; the middermis type had 6 cases of blue black color and 2 cases of dark brown color, query number of cases of slate color; the superficial-middermis type had 12 cases of blue black color, 10 cases of dark brown color, 7 cases of brown color and 6 cases of slate color: the mid-lower dermis type had 3 cases of blue black color; for the diffuse type, the superficial dominant type had 13 cases of brown color, query number of cases of blue black color and 7 cases of dark brown color; the mid-dermis dominant type had 4 cases of brown color, query number of cases of dark brown color, the dispersed type had 14 cases of blue black color and 5 cases of brown color, the deep dominant type had 1 case of blue black color. Conclusion: The histological reclassification of Ota`s nevus may be very useful in making a therapeutic prognosis of the disease. (Korean J Dermatol 2004;42(3):272~280)

인체 모낭기관배양에서 substance P 가 모발성장에 미치는 영향

이원수,손인범 대한피부과학회 2001 대한피부과학회지 Vol.39 No.2

Background: In vitro, some neuropeptides, including substance P(SP), act as a growth factor. The cyclic growth of the richly innervated hair follicle offers a model for probing such functions in a complex, developmentally regulated tissue interaction system under the physiologic condition. Dissecting the role of neuropeptides in this system may also reveal as yet obscure neural mechanisms of hair growth control. Objective: The purpose of this study was to investigate the effect of SP on human hair growth using a recently described model in which isolated hair follicles are grown in vitro. Methods:After the healthy human hair follicles without any visible damage were collected, they were cultured in DMEM with several combination of supplements including insulin, hydrocortisone, sodium selenite, human transferrin, fetal bovine serum at 37℃ in an atmosphere of 5% CO_2 /95% air incubator, and SP was added to the media. The culture media were supplemented with final concentration of 10^(-6),10^(-7),10^(-8) M SP dissolved in DMEM. The results were evaluated by measuring linear hair fiber growth and hair follicle morphology on light microscopy and electron microscopy and by measuring radioisotope uptake of [methyl-^3H] thymidine and [U-^14C] leucine of hair follicle. Results: The following results were obtained from this study. 1. SP did not have an statistically significant effect on the rate of linear hair growth in cultured hair follicles. However, it prolonged the anagen stage of hair cycle. 2. We could not find morphological differences of hair follicles cultured in SP groups compared with those cultured in control group. 3. DNA and protein synthesis in hair follicles increased steadily for 5 days of culture. Conclusion: From the results, we can conclude that SP has growth-stimulatory effect and especially prolongs the duration of anagen phase without affecting the rate of linear hair growth.

천공성 탄력섬유성 위황색종 1예

안성구,황상민,송동훈,최응호,손인범 대한피부과학회 2000 大韓皮膚科學會誌 Vol.38 No.3

Perforating pseudoxanthoma elasticum is a localized, cutaneous disorder found mostly in obese, multiparous middle-aged women. It is characterized clinically by a slowly enlarging, yellowish, well-defined reticulated plaque usually in the periumbilical area with keratotic papules scattered on its surface, and histologically by transepidermal elimination of altered basophilic calcified elastic fibers, which are short, fragmented, and curled, in the middle portion of the reticular dermis. We present a case of a 36 year-old female who had a skin lesion, which showed chracteristic features consistent with perforating pseudoxanthoma elasticum in her neck region but not in the periumbilical area.

색소성 파젯양 Bowen 병 1예

안성구,김수찬,손인범 대한피부과학회 2000 大韓皮膚科學會誌 Vol.38 No.12

Bowen's disease is an intraepidermal squamous cell carcinoma also referred to as a squamous carcinoma in situ. Pigmented Bowen?s disease is a rare variant and represents less than 2% of all lesions. Clear cell Bowen's disease, also known as pagetoid Bowen's disease is also rare and characterized by an atypical proliferation of pale tumor cells within the epidermis. We report an unusual case of Bowen's disease in a 50-year-old man which presented as a brown to black colored scaly plaque with crusts on the back. The histopathologic feature of the skin lesion showed Bowen's disease with increased basal pigmentation, dermal melanophages and epidermal clear cells. So we termed this case 'pigmented pagetoid Bowen?s disease'