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손우찬,김형진,이영순 한국독성학회 1991 Toxicological Research Vol.7 No.1
Complexities of testis structure and function are emphasized in morphometrical and genotoxic evaluation by statistical analysis. F-344 rats were treated with azinphos methyl, cyclophosphomide, and dichlorvos. And Brdu was injected with intrapertionially before sacrifice. The existence and degree of DNA damage were measured by Brdu labeling index which represented relative amount of Brdu incorporated in DNA, morphometric change was evaluated by the relative length of tubular diameter in circular seminiferous tubules and the number of spermatogonia per Sertoli cell in stage IX seminiferous tubules.
독성병리 Peer Review의 중요성과 실제적 접근방법
손우찬(Woo-Chan Son),김배환(Bae-Hwan Kim),장동덕(Dong-Deuk Jang),한범석(Beom-Seok Han),양기화(Ki-Hwa Yang),이영순(Yong-Soon Lee) 한국독성학회 2004 Toxicological Research Vol.20 No.1
Evaluation of toxicological pathology is to some extend subjective judgments by pathologist and the accuracy of pathologist’s works is based on the individual training and experiences. It has been required to establish a peer review system for toxicologic pathology and these review system has been employed by various practice of toxicological pathology. It would be pointed out that the possible causes of drifts in pathology are due to 1) lack of knowledge or experience of individual pathologists, 2) poorly maintained consistence of grading among animals in study, 3) different interpretation of findings between pathologists, or 4) pathology data processing. Example cases of diagnostic errors and current practice of peer review including tissue selection criteria, documentation and problem resolution for short-term and carcinogenicity studies were introduced. For sound regulatory<br/> system and high integrity of practice in toxicological pathology, current approaches of peer review system were reviewed.
손우찬(Woo-Chan Son) 한국실험동물학회 2005 Laboratory Animal Research Vol.21 No.2
It is vital to understand background data such as normal phisiology, anatomy, biochemical events and background pathology in the use of laboratory animals. As minipig is rarely used laboratory species, the basic background data are scarce. In order to establish a general profile of histopathologic background data in 1-year old Göttingen minipigs, data from 32 minipigs were collected, and characteristic histologic features were tabulated and described. The most common findings were a minimal degree of inflammatory cell infiltrate found in the kidney, lungs, gastrointestinal tract, or adrenal glands; followed by mineralisation seen in the lungs, thymus, salivary glands, kidney or pituitary. Arteritis/periarteritis found in the kidney and stomach were morphologically similar to idiopathic canine polyarteritis in Beagle dogs. Testicular degeneration of tubular germinal epithelium, mostly found bilaterally, was seen in 12 out of 16 minipigs. There were many other findings but generally minimal grade and occur in other laboratory animal species. The aim of this report is to provide minipig users with a useful reference guide to aid sound understandings.