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유은숙(Eun Sook Yoo),김옥희(Ok Hee Kim),손여원(Yeo Won Son),정인경(In Kyung Jung),이상섭(Sang Sup Lee) 대한약학회 1999 약학회지 Vol.43 No.1
To investigate analgesic mechanism of capsaicin and its analogues (capsaicinoids), adenosine release was measured by high performance liquid chromatography from rat spinal cord synaptosomes. Exposure of synaptosomes to K+ and morphine Produced a dose dependent release of adenosine in the presence of Ca++. Capsaicin (0.1, 1, 10mcM), and its analogues; NE-19550 (1, 10, 100mcM), DMNE (1, 10, 100mcM) and KR 25018 (0.1, 1, 10mcM) produced a concentration dependent release of adenosine in the presence of Ca++. Nifedifine, L-type voltage sensitive calcium channel blocker, inhibited K+ (6, 12mM)- and morphine (10mcM)-evoked release of adenosine partially. Capsazepine, a novel capsacin selective antagonist, blocked only capsaicin and capsaicinoids induced release of adenosine. Therefore, it is suggested that the adenosine release by capsaicin and capsaicinoids having antinociceptive effects involves activation of capsaicin specific receptor and capsaicin sensitive Ca++ channel.