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피부 악성 종양에서 EGFR의 발현과 금 나노 입자를 이용한 Molecular Labelling에 대한 연구
손수빈 ( Soo Bin Son ),송해준 ( Hae Jun Song ),오칠환 ( Chil Hwan Oh ) 대한피부과학회 2009 대한피부과학회지 Vol.47 No.2
Background: The potential benefits of a molecular characterization of cancer are clear. Because of this, there is pressing need to perform in vivo imaging of the molecular features of cancer. However, before designing an appropriate molecular targeting technique utiilizing a cancer-related target molecule such as epidermal growth factor receptor (EGFR), it is necessary to characterize the exact expression of the target molecule. Objective: The objective of this study was twofold. Our first goal was to characterize the expression of EGFR in skin cancer, and second, to develop nanoparticles conjugated with antibodies, demonstrating their use as optical probes for detecting cancer cells in vitro. Methods: We performed immunhistochemical analysis of EGFR expression in skin cancer using monoclonal antibodies. Gold nanoparticles were synthesized and allowed to conjugate to anti-EGFR in epithelial cancer tissue. Following an incubabtion period, we recorded surface plasmon resonance images using gold nanoparticles conjugated to anti-EGFR antibodies. Results: Specific membranous binding of EGFR was detected in all of the 10 non-melanoma skin cancers. Surface plasmon resonance images using gold nanoparticles also showed light scattering around tumor cells. Conclusion: These ex vivo results demonstrate that optical imaging using gold nanoparticles can allow selective detection of human epithelial cancer cells. Our study demonstrates the potential of gold nanoparticles to target, probe, and illuminate cancer cells making them an effective biomolecular cancer detection tool. (Korean J Dermatol 2009;47(2):172∼179)
Acute Diffuse and Total Alopecia of the Female Scalp
손수빈 ( Soo Bin Son ),신재빈 ( Jae Bin Shin ),서수홍 ( Soo Hong Seo ),손상욱 ( Sang Wook Son ),김일환 ( Ill Hwan Kim ) 대한피부과학회 2008 대한피부과학회지 Vol.46 No.10
Diffuse alopecia areata is the least common clinical type of alopecia, and this diffuse form lacks the characteristic hairless patches of alopecia and it begins as diffuse hair loss. Diffuse alopecia areata has been poorly characterized. In 2002, there was a suggestion to define this form of alopecia areata as acute, diffuse and total alopecia of the female scalp (ADTAFS). ADTAFS is characterized by a marked female predominance, tissue eosinophilia and a uniquely short clinical course. We report here on one case of ADTAFS. (Korean J Dermatol 2008;46(10):1407∼1410)
윤명희(Myung-Hee Yoon),손수빈(Soo-Bin Son) 한국문화사회학회 2015 문화와 사회 Vol.18 No.-
이 연구는 ‘트위터 봇’ 현상을 SNS 사용자들의 쌍방향적인 "정체성 놀이"의 맥락에서 접근하고, 트위터 봇과 봇 팔로워간의 상호작용 방식에 대한 질적 분석을 수행하고 있다. 먼저 이 연구는 사이버공간의 사용자정체성에 대한 연구경향들을 비판적으로 검토하고 사이버사용자 정체성의 구성적이고 수행적이고 놀이적인 특성에 주목한다. 다음으로, 이 연구는 트위터 봇 가운데 역할놀이적인 상호작용성이 뚜렷한 캐릭터 봇에 대한 질적 연구를 수행하고 있다. 주요 연구방법은 의도하지 않은 참여관찰과 온?오프라인 심층면접같은 문화기술지이며, 연구참여자는 트위터 봇 계정 관리자와 트위터 봇 팔로워들이다. 분석 내용을 개략하면 다음과 같다. 첫째, 트위터 봇은 ‘역극’을 통해 작품 혹은 작품 내 캐릭터의 역할을 수행하며, 이 때 트위터 봇의 캐릭터 정체성은 주어진 상황, 즉 ‘세계관’에 기반하여 재현된다. 둘째, 다른 한편으로, 트위터 봇의 정체성은 상당부분 유동적인데, 이것은 캐릭터의 상황적 변형과 함께, 성별이나 나이, 성격을 전격적으로 교체하는 ‘캐릭터변화’에서 뚜렷하게 드러난다. 셋째, 트위터 봇과 그 팔로워들은 특정한 캐릭터의 역할을 수행하는 단순한 가면놀이에서 나아가, 봇 참여자들 상호간의 재미와 정서적 친밀감을 강화하는 놀이적 상호작용을 지속한다. This study is a qualitative analysis about interactivity between Twitter bots and their followers, approaching from the viewpoint of identity play. First, through reviewing existing research on cyber-identities, this study focuses on the constructive, performative and playful characteristics of identities in cyberspace. Next, this study performs qualitative research on a Twitter Bot of a role-playing type such as a character bot. The main research methods used are: ethnography method such as an unintentional participant observation, in-depth interview off-line and on-line and study of participants including Twitter Bot account managers and Twitter Bot followers. Analysis is as follows: First, Twitter Bots, through a "yeokgeuk", are performing the typical roles as a character in the play and these characters’ identity as Twitter bots is based on given circumstances so-called "segegwan’. Second, identities of Twitter Bots are pretty fluid, which clearly appears through transforming situational condition in role play and changing gender, age and character"s personality. Third, Twitter Bots and their followers continue playful interaction as a social interaction to enhance enjoyment and emotional intimacy with each other in addition to ‘masque play’ to perform the role play of a particular character.
Blaschko 선을 따라 발생한 선천멜라닌세포모반 1예
최명훈 ( Myeung Hun Choi ),손수빈 ( Soo Bin Son ),송해준 ( Hae Jun Song ),오칠환 ( Chil Hwan Oh ) 대한피부과학회 2008 大韓皮膚科學會誌 Vol.46 No.12
Nevus spilus, also known as speckled lentiginous nevus, is a relatively common cutaneous lesion that is characterized by multiple pigmented macules within a pigmented patch. It may be congenital or acquired, and it can show the histological features of congenital melanocytic nevus (CMN). The possible relationship between nevus spilus and CMN has been contentious. We report a case of a congenital nevus that followed the line of Blaschko and clinically manifested as nevus spilus, but showed the histological features of CMN. (Korean J Dermatol 2008;46(12):1654∼1656)
벌침 치료 받은 후 발생한 피부괴사를 동반한 이물 육아종
배의종 ( Eui Jong Bae ),손수빈 ( Soo Bin Son ),서수홍 ( Soo Hong Seo ),손상욱 ( Sang Wook Son ),김일환 ( Il Hwan Kim ) 대한피부과학회 2009 대한피부과학회지 Vol.47 No.3
Bee sting therapy is sometimes used for the treatment of chronic recalcitrant neuralgia and arthralgia and chronic eczema in traditional Korean herbal medicine. The stings of many insects are withdrawn after stinging. However, in certain cases, retained sting materials at the treatment site may induce granulomatous inflammation. A 76-year-old man presented with an erythematous plaque containing a central ulcer and granulation tissue after he had undergone bee sting therapy for a palpable subcutaneous nodule in the right axilla area and eczema on the back. The biopsy specimen showed a granulomatous response marked by histiocytes and giant cells surrounding foreign material. Histologic examination of the subcutaneous nodule in the right axilla showed mature fat cells consistent with a lipoma. Thus, we report a rare case of a foreign body granuloma with skin necrosis occurring after bee sting therapy. (Korean J Dermatol 2009;47(3):350∼353)
배의종 ( Eui Jong Bae ),손수빈 ( Soo Bin Son ),서수홍 ( Soo Hong Seo ),손상욱 ( Sang Wook Son ),김일환 ( Il Hwan Kim ) 대한피부과학회 2009 대한피부과학회지 Vol.47 No.9
An interdigital pilonidal sinus is considered a rare occupational disease related to individuals with short hair. We describe a case of a 44-year-old man who presented with a tender nodule with a purulent discharge in the fourth interdigital web space of the left foot. The biopsy specimen showed a sinus tract surrounded by keratin and squamous epithelium, and the track contained acute and chronic inflammatory cells. The skin lesion was improved with occlusion of the fistula by using 100% bichloracetic acid. We herein report on a rare case of a interdigital pilonidal sinus in the foot, and this occurred with no relation to the patietn`s occupation. (Korean J Dermatol 2009;47(9):1074∼1076)
백유상 ( Yoo Sang Baek ),신원웅 ( Won Ung Shin ),오태석 ( Tae Seok Oh ),손수빈 ( Soo Bin Son ),송해준 ( Hae Jun Song ),오칠환 ( Chil Hwan Oh ) 대한피부과학회 2011 대한피부과학회지 Vol.49 No.7
Kaposi`s sarcoma (KS) is a multifocal proliferative vascular tumor involving cutaneous and extra-cutaneous tissues. KS has been reported in patients treated with immunosuppressive agents for autoimmune diseases. However, KS has rarely been reported in patients with iatrogenic Cushing`s syndrome. A 77-year-old woman was evaluated with multiple asymptomatic violaceous nodules and plaques on both lower legs. She had been diagnosed with iatrogenic Cushing`s syndrome and had been treated with low-dose corticosteroid replacement therapy for >10 years. A histopathologic study showed extensive vascular proliferation in the dermis with spindle-shaped cells. Immunohistochemical staining for CD31, CD34, human herpesvirus (HHV)-8, and D2-40 was positive. We hereby report a case of KS in a patient with iatrogenic Cushing`s syndrome.
신원웅 ( Won Ung Shin ),오태석 ( Tae Seok Oh ),백유상 ( Yoo Sang Baek ),손수빈 ( Soo Bin Son ),송해준 ( Hae Jun Song ),오칠환 ( Chil Hwan Oh ) 대한피부과학회 2011 대한피부과학회지 Vol.49 No.11
Sclerotic fibroma is a rare skin neoplasm that can occur seen sporadically or in association with Cowden`s disease. Clinically, it presents as asymptomatic flesh-colored or pinkish slow-growing papules or nodules with a wide anatomical distribution. We report a rare case of pedunculated type of sclerotic fibroma resembling soft fibroma, which has not been reported in Korea. (Korean J Dermatol 2011;49(11):1032∼1034)
백유상 ( Yoo Sang Baek ),신원웅 ( Won Ung Shin ),오태석 ( Tae Seok Oh ),손수빈 ( Soo-Bin Son ),송해준 ( Hae Jun Song ),오칠환 ( Chil Hwan Oh ) 대한피부과학회 2011 대한피부과학회지 Vol.49 No.1
Vitamin K1 dermatitis is a cutaneous adverse reaction to vitamin K1, and this malady presents as an erythematous eczematoid patch or pseudoscleroderma. At first, liver disease was thought to be related to vitamin K1 dermatitis. However, it is no longer considered as being related to liver disease due to the increasing case reports of patients with vitamin K1 dermatitis and who are without liver disease. Type IV hypersensitivity reaction was suspected to be the cause of this reaction. This disease can be easily ignored because of its low incidence. We hereby report on a case of vitamin K1 dermatitis that was confirmed by a skin test. (Korean J Dermatol 2011;49(1):58~61)