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성희정 ( Hui Jeong Seong ),이상남 ( Sang-nam Lee ),박지하 ( Ji-ha Park ) 한약응용학회 2020 한약응용학회지 Vol.20 No.2
Objective : The objective of this study was to obtain the primary safety information about AR extracts, lyophilized water extract of Arisaema amurense Maxim. var. serratum Nakai and further clarifies their safety for clinical use. Methods : In order to observe the 50% lethal dose (LD50), approximate lethal dosage (ALD), maximum tolerance dosage (MTD) and target organs, test articles were once orally administered to female and male ICR mice at dose levels of 2,000, 1,000, 500 and 0 (control) ㎎/㎏ (body weight) according to the recommendation of KFDA Guidelines [2005-60, 2005]. The mortality and changes on body weight, clinical signs and gross observation were monitored during 14 days after dosing according to KFDA Guidelines [2005-60, 2005] with organ weights and histopathology of 12 types of principle organs. Results : The LD50 and ALD of AR extracts in both female and male mice were considered as over 2,000 ㎎/㎏ because no mortalities were detected upto 2,000 ㎎/㎏ that was the highest dose recommended by KFDA and OECD Guidelines. Because increases of frequencies of hepatocyte acute cellular swelling and related pale yellow discolorization with increases of liver weights were detected from 1,000 ㎎/㎏ of AR extracts-treated male and from 2,000 ㎎/㎏ in female mice, and the liver is considered as a primary target organ of AR extracts in this study. Conclusion : The results obtained in this study suggest that the overdose ( ~ 1,000 ㎎/㎏ in male and ~ 2,000 ㎎/㎏ in female) of AR extract has slight reversible hepatotoxicity (acute cellular swelling) in mice and is therefore carefully to be used for clinical use.
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성희정 ( Hui Jeong Seong ),서부일 ( Bu Il Seo ),박지하 ( Ji Ha Park ) 대구한의대학교 제한동의학술원 2011 東西醫學 Vol.36 No.4
We investigated 62 genus of original plant used in Ayurvedic medicine. To achieve this, we took reference of major publications related to Ayurvedic medicinal herbs such as Indian Herbal Remedies, Major herbs of Ayurveda, Prime Ayurvedic Plant Drugs. The results were summarized as follows 1. Original plants of Leonuri Herba(益母草), Styrax(蘇合香), Meliae Cortex(苦련皮) used in TKM did exactly correspond with those of Ayurvedic medicine. 2. Original plant of Hordei Fructus Geninatus(麥芽) used in TKM is Hordeum vulgare Linne such as that of Ayurvedic medicine. In addition to this, Hordeum saivum also is original plant which have the same efficacy in Ayurvedic medicine. We anticipate that it will be alternative plant of medicinal herbs. 3. In Ayurvedic medicine, Glycyrrhizae Radix(甘草), Hordei Fructus Germinatus(麥芽), Leonuri Herba(益母草), Styrax(蘇合香), Meliae Cortex(苦련皮) reveal varied efficacies according to compounding, additives, dosage forms, parts of medical herb.
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