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- 저자 : 성상율 (검색결과 2 건)
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성상율,구자섭,조근호,원승희,이종훈,박종한 대한생물치료정신의학회 2004 생물치료정신의학 Vol.10 No.1
Objectives : Nowadays many studies with MRI have reported structurai abnormalltles of corpus callosum of schizophrenic patients. However, the results are various and inconstant. In this study, we attempted to identify structural change of C O ~ U S cailosurn. Method : We measured the size of corpus callosum of the 24 schizophrenia patients (male 11, female 18) who were diagnosed by DSM-IV (19943, visited at department of psychiatry, catholic university hospital of Daegu from January 2002 to December 2003, by using midline sagittal slice of MRI. These results were compared with the size of corpus callosum of 25 controls (male 7, female 78). We divided corpus callosurn into 7 areas. We calculated and compared the areas of each subregion, mid-sagittal cerebral area, and entire corpus callosum. The results were analyzed by independent t-test. Result :When we compared subregion to corpus callosum adjusted wth mid-sagittal cerebral area, schlzoph-renia patients had significantly smaller genu (1.64k0.32 vs. 1.43k0.26 p<O.O5) and splenium (2.16f0.27 VS. 1.96+0.30 ; ~(0.05). Similarly, the ratio of total corpus callosum to midline sagittal cerebral area (%)(7.50*0.72 vs. 6.90t0.82 ~(0.05) was significantly smaller In schizophrenia than control group. Conclusion : In this study, we found significant differences in corpus callosum between schizophrenic patients and normal control group.
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한국인 청소년 재소자들의 충동성 및 공격성과 도파민 수송체 유전자 다형성의 연관성 연구
성상율,최태영,이종훈 대한생물치료정신의학회 2012 생물치료정신의학 Vol.18 No.1
Objectives:Impulsive aggression plays a critical role in the manifestation of violent and criminal behavior in adolescents and it also is a complex behavioral phenotype. The understanding brain mechanisms underlying impulsive aggression and identification of genetic risk factors is important to the prevention and treatment of impulsive aggression. Dopaminergic system plays an active role in the modulation of aggressive behaviors and hyperactivity in the dopamine system is associated with increases in impulsive aggression. We investigated the association of the impulsive aggression in Korean adolescent prisoners with DAT1 3'-untranslated region(UTR) variable number of tandem repeat(VNTR) polymorphism. Methods:We recruited 198 male adolescent prisoner volunteers and 68 healthy controls and investigated the dopamine transport gene(DAT1) polymorphisms. Impulsive symptoms were measured using Barratt Impulsiveness Scale (BIS) and Achenbach's Child Behavior Checklist(CBCL). We divided all subjects into three groups by BIS, and then we compared genetic frequency and allele frequency between each subgroup. Results:The distribution of the genotype in adolescent prisoners with 7/7, 9/10, 10/10, 10/11 were 7(3.8%), 12 (6.6%), 158(86.3%), 6(3.3%) and the controls were 2(3.2%), 5(8.1%), 52(83.9%), 3(4.8%), respectively. No significant differences for genotype distribution were revealed between adolescent prisoners and normal controls. Also there was no significant difference of genotype distribution between subgroups. Conclusions:We failed to reveal the association between DAT1 polymorphism and impulsive aggression. In the future, larger sample size studies should continue to invest effort toward identifying the biological and genetic risk factors underlying impulsive aggression for developing effective treatment strategies.
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