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피부 전이로 진단된 횡문근양 표현형을 동반한 대세포 폐암
서현민 ( Hyun Min Seo ),김정인 ( Jung In Kim ),김윤환 ( Yoon Hwan Kim ),민준홍 ( Joon Hong Min ),이승재 ( Seung Jae Lee ),박지혜 ( Ji Hye Park ),김원석 ( Won Serk Kim ),이가영 ( Ga Young Lee ) 대한피부과학회 2014 대한피부과학회지 Vol.52 No.4
Large cell carcinoma with a rhabdoid phenotype is very rare. We report the case of a 53-year-old man who presentedwith multiple nodules on the scalp, face, and trunk. A skin biopsy revealed large cell carcinoma with a rhabdoidphenotype throughout the dermis. Tumor cells had abundant cytoplasm, eccentric nuclei, and prominent nucleoliand did not adhere to each other. Immunohistochemical tests showed positive reactions for vimentin, epithelialmembrane antigen (EMA), and thyroid transcription factor-1 (TTF-1) and weakly focal reactions for pan-CK, CK7,and p63. Imaging studies and a percutaneous lung biopsy were performed and the results were consistent with alarge cell lung carcinoma with a rhabdoid phenotype. Based on these clinical and histopathological findings, weconcluded that his condition was a cutaneous metastasis from a large cell lung carcinoma with a rhabdoidphenotype, which occurs very rarely.
서현민 ( Hyun Min Seo ),정호주 ( Ho Joo Jung ),박지혜 ( Ji Hye Park ),이가영 ( Ga Young Lee ),김원석 ( Won Serk Kim ) 대한피부과학회 2014 大韓皮膚科學會誌 Vol.52 No.7
Background: Keratoacanthoma (KA) can be clinically differentiated with ease from other dermatoses. However, the differential diagnosis of KA can sometimes be difficult, and some cases clinically suggest that the results of skin biopsies of lesions thought to be KA indicate other diseases. Objective: The purpose of this study is to examine the diagnostic yield in submitting clinically diagnosed KA that showed solitary symmetric, firm, erythematous, or skin-colored nodules. Methods: We retrospectively reviewed the clinical records of 54 patients with a clinical diagnosis or differential diagnosis of KA who received biopsies and visited the department of dermatology from January 2004 to December 2013. We compared clinical and histopathologic diagnoses and analyzed the rate of concurrence. In addition, clinical features, including age, sex, location, and duration were investigated. Results: Of the patients, 40.7% were clinically diagnosed with KA, but the results of the histopathology tests indicated other diseases. The mean age of the patients with KA was 72.8 years, and the ratio of men to women was 1 : 0.92. Of the new patients, 0.07% had KA, and most of the lesion sites (84.0%) were caused by sun exposure. Other diseases that are more common in patients with KA are squamous cell carcinoma (55.2%), basal cell carcinoma (20.7%), seborrheic keratosis (6.9%), verruca vulgaris (6.9%), pyogenic granuloma (3.4%), clear cell acanthoma (3.4%), and Bowen`s disease (3.4%). Conclusion: Skin lesions thought to be KA need more examinations, and skin biopsies of appearances of clinically atypical lesions that cannot completely exclude the possibility of precancerous or malignant lesions are strongly recommended. (Korean J Dermatol 2014;52(7):465∼470)
한국인 뾰족콘딜로마 환자의 임상 및 사람유두종바이러스 유전자형에 대한 분석
최현석 ( Hyun Seok Choi ),서현민 ( Hyun-min Seo ),김정수 ( Joung Soo Kim ),유희준 ( Hee Joon Yu ) 대한피부과학회 2017 대한피부과학회지 Vol.55 No.7
Background: Condyloma acuminatum is a sexually transmitted disease (STD) associated with the human papillomavirus (HPV). Although it is a relatively common disease, there has been no epidemiological and clinical study of condyloma acuminatum performed in Korea since 1978. Objective: We aimed to evaluate the clinical features of condyloma acuminatum in Korean patients, to identify the genotypes of HPV, as well as determine factors associated with recurrence of condyloma acuminatum. Methods: We studied 80 patients (60 men and 20 women) diagnosed with condyloma acuminatum. We analyzed age, sex, duration of the disease, number and locations of lesions, underlying diseases and co-infection with STDs, treatment modalities, and number of relapses. Additionally, 26 patients were analyzed for HPV subtypes. We also evaluated factors affecting recurrence of condyloma. Results: Mean age at the time of diagnosis was 36.9±17.7 years and mean duration of disease was 7.2±16.5 months. The most common sites of involvement were found to be the penile shaft in men and the labia majora in women. We observed that 28 patients showed relapse with a mean duration of 1.5±4.5 months. HPV genotyping revealed that type 6, 11, and 44 genotypes that are associated with a low risk of malignancy were detected in 76.9% of cases, and type 16, 18, 51, 52, and 66 genotypes associated with a high risk of malignancy were detected in 15.3% cases. A significant relationship was observed between the recurrence rates of condyloma acuminatum and the rates of co-infection with STDs and the number of lesions. Conclusion: We report a recent epidemiological and clinical review analyzing genotypes of HPV in Korean patients presenting with condyloma acuminatum. (Korean J Dermatol 2017;55(7):394∼400)
서만수(Mansu Seo),고민호(Min-Ho Ko),선정운(Jeong-Woon Sun),서현민(Hyun-Min Suh),이재준(Jae Jun Lee),강선일(Sunil Kang) 한국추진공학회 2016 한국추진공학회 학술대회논문집 Vol.2016 No.5
발사대 시스템의 산화제 공급계(Liquid Oxygen Filling System)는 발사체의 추진제(Propellant) 중 연료의 연소를 위한 산화제(Oxidizer)로 사용되는 액체 산소(Liquid Oxygen)를 저장하고, 발사체 요구조건에 맞게 공급하는 하는 설비이다. 본 논문에서는 한국형 발사체(KSLV-II) 발사대 시스템 상세설계(Critical Design, 2015년 8월에서 2016년 4월, 8개월) 동안 수행된 한국형 발사체 발사대 시스템 추진제 공급설비의 산화제 공급계 설계 내용을 주요 설비 구성에 대하여 구조적 관점으로 소개한다. In this paper, the liquid oxygen filling system (LOXFS) of the launch complex system of Korea Space Launch Vehicle-II (KSLV-II) is introduced based on critical design result by KARI in 2015 to 2016. The function and specification of the main systems of the liquid oxygen filling system, such as the storage tank, the drainage tank, the supply pumping system, the curved heat exchanger with liquid nitrogen, end valve block system, and umbilical connection, are presented.