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서웅석(Woong Suck Suh),이무형(Mu Hyoung Lee),박재경(Jai Kyung Park),허충림(Choong Rim Haw) 대한피부과학회 1991 大韓皮膚科學會誌 Vol.29 No.2
To evaluate the effects of kerationocytes on the growth of melanocytes, keratinocyte conditioned media (K-CM) with different molecular weight obtained by dialysis were added to melanocyte growth medium (M-GM). In addition, K-CM only, and K-CM mixed with each component of M-GM, such as TPA(12-tetradecanoyl- phorbol-13-acetate), IBMX(isobutylmethylxanthine) and CT(cholera toxin), were used for the culture of melanocytes. 1) The proliferation of melanocytes was incresased to 2.86 x 10'+0.87 x 10 cells/ well and 2.87 x 10'+0.71 x 10' cells/well in 25% K-CM with a cut-off molecular weight of 2,000 and 25% K-CM with a cut,-off molecular weight between 6000 8000 respectively, as compared to 1.88 x 10'+0.45 x 10' cells/well in the control group (p < 0.05). 2) The amount of melanin was increased to 0.2987+0.0830ng/mlin 25% un- dialyzed K-CM, as compared to 0.2264+0.0643ng/ml in the control group, but this differnce was not statistically significant. 3) Maximum proliferation of melanocytes was observed in 35% concentration of K-CM with a cut-off molecular weight of 6000 8000. 4) Maximum of melanin production was observed in 35% concentration of undialyzed K-CM 5) As compared to 7.86 x 10+ 1.74 x 10 cells/well in M-GM,proliferation of melanocytes in 35% K-CM with a cut-off molecular weight of 6000 8000 was de- creased to 1.38 X 10+ 0.97 X 10 cells/well. 6) There was no difference in melanocyte proliferation between 6.81 x 10'+2.19 x 10 cells/well in 35% 6,000 8,000 M.W. cut-off dialyzed K-CM, with IBMX only, and 7.86 x 10 +1.74 x 10 cells/well in M-GM. 7) Compared to 0.2303+0.0700ng/well cell in M-GM, the amount of melanin was increased to 0.3227 + 0.0900ng/cell, 0.3624+ 0.0900ng/cell and 0.2928+ 0.0500ng/cell, respectively, when TPA, IBMX, CT was added to 35% undialyzed K-CM. It also increased to 0.3176+0.1100 in 35% undialyzed K-CM(p<0.05). In summary, the results proved that cellular activating substances released from keratinocytes affect the proliferation of melanocyte and the synthesis of melain. It is also expected that methods used in this study can be clinically utilized because melanocyte culture is possible on K-CM without adding tumor promotors. (Kor J Dermetol 29(2):139 150)
서웅석(Woong Suck Suh),이기호(Ki Ho Lee),허충림(Choong Rim Haw),윤재일(Jai Il Yoon),임수덕(Soo Duk Lim) 대한피부과학회 1983 대한피부과학회지 Vol.21 No.1
Erythrasma is a chronic, superficial bacterial skin infection involving the body folds and toewebs, and sametimes it may be generalized. The causative organism of this disease is Corynebacterium minutissimum. But, in Korea, there are few reported case about this common condition. We experienced a case of erythrasma on 39-year-old male who have had well defined, brownish fine scaly patches on both crural areas for 15 years. We had treated this patient with topical antifungal agent for 1 month under impression of tinea cruris, But skin lesion was not improved. So, we reexamined the lesion and diagnosed it as genitocrural form of erythrasma with it's clinical appearance, red fluorescence under Wood's light. And we treated it with oral erythromycin.