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방형애(Hyung-Ae Pang),이용욱(Young Wook Lee),서난주(Nan Joo Suh),장일무(Il-Moo Chang) 한국생약학회 1990 생약학회지 Vol.21 No.1
In terms of regulatory toxicology, especially for the traditional Chinese medicines, problems can be arise from a fact that there is no distinctive barrier between herbal drugs and food/beverage. An example is that many kinds of Chinese herbal materials have been also used as tea materials in Korea, China, Japan and Vietnam. Sixteen tea materials (also used as herbal materials) were extracted with 70% ethanol and the extract further partitioned with chloroform and water. Those ethanol extract and fractions were subjected to the SOS-Chromotest to examine potential mutagenicity. It was found that ethanol extract of Chaenomelis Fructus (Chaenomeles japonica Lindley, 木瓜, Rosaceae) and both ethanol extract and water fraction of Cassiae Semen (Cassia tora Linne, 決明子, Leguminosae) showed relatively high mutagenic activities in SOS-Chromotest.
서정숙(Jung Sook Seo),이용욱(Young Wook Lee),서난주(Nan Joo Suh),장일무(Il-Moo Chang) 한국생약학회 1990 생약학회지 Vol.21 No.1
Potential antimutagenic activities of vegetable plants were investigated. 24 vegetables which are frequently consumed by Korean people were extracted with 70% ethyl alcohol to prepare the extract samples. Then those samples were added to the culture media containing mitomycin C(0.3 ㎍/㎖) and the SOS-Chromotest was performed. Positive control, mitomycin C alone, showed about 330 units of b-galactosidase activities. Among 24 vegetable samples, Saxifraga oblougifolia Nakai (취나물, Saxifragaceae) and Platycodon grandiflorum A. De Candolle(도라지, Campanulaceae) showed 136 and 155 units, respectively when mitomycin C was treated. These results indicate that Saxifragae Herba and Platycodi Radix possess protecting action from mutagenic activity produced by mitomycin C.