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RISS 인기검색어
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- 저자 : 빈기태(Khi Tai Bhin) (검색결과 1 건)
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윤성철(Sung Chul Yun),윤윤수(Yun Soo Yun),빈기태(Khi Tai Bhin),신영태(Young Tai Shin) 대한내과학회 1996 대한내과학회지 Vol.51 No.5
N/A Objectives: Interleukin-6 (IL-6) is a pleiotrophic cytokines which is related to immune system activation, acute phase reactants, hematopoietic regulatory function, and cell growth as well as the first cytokine that may be directly related to pathogenesis of autoimmune disease, as systemic lupus erythematosus. The production site of IL-6 has been confined to T cell, B cell, macrophage, fibroblast, myeloma cell, myxoma cell, endothelial cell, especially mesangial cell and other glomerular cell in the kidney until now. However, recently uroepithelial cell stimulated by the bacteria and renal tublar cell damaged by immunologic injury were reported to be a another possible production site of IL-6. Therefore, Authors chose cases of lupus nephritis that was confirmed by renal biopsy. Methods: We observed the expression of IL-6 by using the immunohistochemical staining and tried to estimate the role of IL-6. The patients classified as class 4, 5 that had a strong proliferative change histologically were mainly selected as specimens for a research. The specimens were studied immunohistologically and its clinical data were compared in various ways. Results: 1) Positive IL-6 expression was observed in 16 cases (80%) of total 20 cases. IL-6 positive cases of glomerulus were accompanied with the strong IL-6 expression of renal tubules all the time. 2) The stronger IL-6 expression more than (+ +) was confirmed in 7 cases of 12 class 4 cases (87.5%). 3) The incidence of nephrotic syndrome and the case of decreased complement (C3, C4) were more prevalent in the group of positive IL-6 when compared to the group of negative IL-6. Conclusions: IL-6 has a strong association with renal tubular cells and play an important role in cellular proliferation of glomerulus as well as in disease activity of lupus nephritis.
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