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RISS 인기검색어
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- 저자 : 변부형 ( Byeon Bu Hyeong ) (검색결과 4 건)
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변부형 ( Byeon Bu Hyeong ),서부일 ( Seo Bu Il ) 대한본초학회 2003 大韓本草學會誌 Vol.18 No.4
연구 목적: Sprague-Daewey rat에 의한 黃芩 藥針의 安全性을 검토하기 위해 國立 保健 硏究院 急性 毒性試驗 基準을 기본으로 하여 急性 毒性 試驗을 修行하였다. 방법: 食品醫藥品 安全性 고시 제1998-116호의 `醫藥品 등의 毒性 試驗 기준`에 준하여 실시하였다. SD계 rat는 독성 시험에 적당한 실험 동물로서 急性 毒性 試驗에 널리 사용되고 있다. 본 계통의 rat는 풍부한 試驗基礎資料가 蓄積되어 있어서, 評價 時 實驗 結果의 해석이 용이하다. 결과: 對照群을 포함한 모든 實驗群에서 外觀 및 一般 行動에서의 이상 症狀은 觀察되지 않았으며, 實驗군에 藥針을 시술한 직후의 行動 이상 및 投與 직후 사이의 行動 이상도 觀察되지 않았다. 또한 剖檢時 이상 소견이 對照群과 모든 投與群에서 觀察되지 않았다. 본 시험에서의 黃金藥針은 安全性에는 문제가 없는 것으로 사료되었다. 황금 약침 施術群에 대한 血液 生化學적인 檢査에서 glucose의 농도는 증가하는 경향(P<0.05)을 나타냈다. 반면에 GOT, GPT 농도는 黃金 藥針 施術群에서 오히려 감소하는 有意性 있는 흥미로운 結果를 얻을 수 있었다. 결론: 食品醫藥品 安全性 고시 제1998-116호의 `醫藥品 등의 毒性 試驗 기준`에 준하여 黃金藥針의 急性 毒性 試驗을 修行한 結果 본 試驗에서의 黃金 藥針은 安全性에는 문제가 없는 것으로 사료되었다. N/A
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길경 분말이 고지방식이로 유도된 비만 흰쥐 혈청 중의 간효소 활성도에 미치는 영향
변부형 ( Byeon Bu Hyeong ),서부일 ( Seo Bu Il ) 대한본초학회 2003 大韓本草學會誌 Vol.18 No.4
N/A Objectives: The present study has been undertaken to investigate the effects of Platycodi Radix powder on the activities of several enzymes in serum of rats fed high fat diet. Methods: Twenty four males of Sprague-Dawley strains weighed about 580g were divided into 4 groups, each group receiving a different diet for 10 weeks ; i.e. control group, control+ 20% Platycodi Radix powder group, high fat diet group, high fat diet + 20% Platycodi Radix powder group. Determinations were carried out on the net weight gain, food efficiency ratio, and AST, ALT, lactate dehydrogenase, alkaline phosphatase activities in serum of rats. Results: The results obtained were as follows : AST, ALT, ALP, LDH of serum were significantly increased in lard containing group but Platycodi Radix powder feeding groups decreased enzyme activities compared to lard group. Conclusions: The above results suggest that Platycodi Radix powder would prevent the metabolic disease of liver by preventing hyperlipemia caused by high fat diet.
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변부형 ( Byeon Bu Hyeong ),서부일 ( Seo Bu Il ) 대한본초학회 2003 大韓本草學會誌 Vol.18 No.3
N/A Objectives: The purpose of this study is to investigate general cell cytotoxicities effects of Cerui Pantotrichurn Cornu Herbal-acupuncture Solution(CPCHA). Methods: In this study we have been carried out to analize the effects of Cervi Pantotrichum Cornu Herbal-acupuncture Solution(1-10 ug/ml) on cytotoxicities in primary culture of adult rat hepatocytes using MTT method, LDH enzyme release, membrane transport of ouabain. Results: The results were obtained a s follows: Hepatotoxicities was not affected by treatment with Cerui Pantotrichurn Cornu Herbal-acupuncture Solution(CPCHA) of 5 ug/ml and 10 ug/ml . In primary culture of adult rat hepatocytes, the treatment of Cerui Pantotrichum Cornu Herbal-acupuncture Solution(CPCHA) did not affect LDH enzyme activity and membrane transport ouabain. In all parameters used in the present studies, CPCHA did not affect these normal functional characteristics. Conclusion: From the above results, it is suggested that Cerui Pantotrichum Cornu Herbal-acupuncture Solution(CPCHA) did not affect normal functional characteristics.
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정국영 ( Jeong Gug Yeong ),서부일 ( Seo Bu Il ),박지하 ( Park Ji Ha ),권순주 ( Kwon Sun Ju ),변부형 ( Byeon Bu Hyeong ),신순식 ( Sin Sun Sig ),이은숙 ( Lee Eun Sug ) 대한본초학회 2003 大韓本草學會誌 Vol.18 No.4
N/A Objectives : The present study has been undertaken to investigate the effects of and Ginseng Radix Palva on osteoporosis in ovariectomized rats. Methods : In this expaiment, the rats were ovariectomihed. Rats were administered by 2 kinds of medicine, Estradiol and Ginseng Radix Palva. The levels of bone mineral density, osteocalcin, ALP, phosphorus, calcium in serum, deoxypyridinoline in urine, calcium, phosphorus, ash weight of bone, body weight and uterus weight were measured. results : The levels of bone mineral density were not significantly increased in comparison with OVX group in Ginseng Radix Palva group. The levels of serum didn`t show significant change in comparison with OVX group in Ginseng Radix Palva group. The levels of urine deoxypyridinoline didn`t show significant decrease in comparison with OVX group in Ginseng Radix group. The levels of femoral and fibula-tibial ash weight didn`t show significant increase in comparison with OVX group in Ginseng Radix Palva group. The levels of femoral and fibula-tibial calcium showed significant increase in comparison with OVX group in Ginseng Radix Palva group. The levels of femoral and fibula-tibial phosphorus showed significant increase in comparison with OVX group in Ginseng Radix Palva group. The levels of body weight didn`t show significant changes in comparison with OVX group in Ginseng Radix Palva group. The levels of uterus weight didn`t show significant changes in comparison with OVX group in Ginseng Radix Palva group. Conclusions : Reviewing these experimental results, it appears that Ginseng Radix Palva have efficacy on osteoporosis. And further study should be conducted to illustrate in depth the curing osteoporosis.
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