피부에 국한된 다발성 Rosai-Dorfman Disease

배유인 ( You In Bae ),이지범 ( Jee Bum Lee ),김성진 ( Seong Jin Kim ),이승철 ( Seung Chul Lee ),원영호 ( Young Ho Won ),윤숙정 ( Sook Jung Yun ) 대한피부과학회 2010 대한피부과학회지 Vol.48 No.4

Rosai-Dorfman disease (RDD) or sinus histiocytosis with massive lymphadenopathy (SHML) is an idiopathic, benign, self-limited, histiocytic proliferative disease confined mainly to cervical lymph nodes. The disease is usually accompanied by massive bilateral lymphadenopathy, fever, elevated erythrocyte sedimentation rate, leukocytosis with neutrophilia, and polyclonal hypergammaglobulinemia. Although cutaneous manifestations are observed in 10% of patients, pure cutaneous RDD without any nodal or systemic involvement is very rare. We report a case of pure cutaneous RDD occurring in a 37-year-old man with asymptomatic erythemaotus to yellowish multiple widespread nodules and tumors on the face and trunk. Histopathologic examination characteristically showed a diffuse infiltrate composed of large histiocytes exhibiting emperiopolesis and mixed inflammatory cells including many plasma cells. Immunohistochemically, these histiocytes were positive for S-100 protein and CD68, but negative for CD1a. During 2 years of follow-up, the patient showed neither nodal nor systemic involvement of the disease and the skin lesions gradually disappeared. The final diagnosis was made by typical cutaneous manifestations without nodal or extranodal involvement and histopathological findings compatible with RDD. (Korean J Dermatol 2010;48(4):300~305)

만성 B형 바이러스 간염과 연관된 범발형 백반증

배유인 ( You In Bae ),이강모 ( Gang Mo Lee ),김정은 ( Jung Eun Kim ),이상훈 ( Sang Hoon Lee ),이성열 ( Sung Yul Lee ),박영립 ( Young Lip Park ) 대한피부과학회 2011 대한피부과학회지 Vol.49 No.12

Vitiligo universalis is an uncommon variant that is rarely seen. Interestingly, vitiligo universalis often accompanies systemic diseases such as endocrinopathies. A 43-year-old man presented with whole body depigmentation and poliosis affecting most of his scalp and body hair. He had undergone a liver transplant 2 years ago due to liver cirrhosis from a chronic hepatitis B infection and has been treated for diabetes mellitus for several years. Histopathology showed no melanocytes and an absence of epidermal pigmentation on the skin. We herein report a rare case of vitiligo universalis associated with chronic viral hepatitis B. (Korean J Dermatol 2011;49(12):1107~ 1110)

Imatinib Mesylate (Gleevec(TM))에 의한 건선양 약진

배유인 ( You In Bae ),윤숙정 ( Sook Jung Yun ),이지범 ( Jee Bum Lee ),김성진 ( Seong Jin Kim ),이승철 ( Seung Chul Lee ),원영호 ( Young Ho Won ) 대한피부과학회 2009 대한피부과학회지 Vol.47 No.6

Imatinib mesylate (GleevecTM, formerly known as STI571) is an oral drug that selectively inhibits bcr-abl, c-kit and platelet-derived factor receptor (PDGFR) tyrosine kinase. It has been used for treating chronic myelogenous leukemia (CML) and gastrointestinal stromal tumors. Various adverse cutaneous reactions have been reported, yet the development of psoriasis or a psoriasiform drug eruption by the drug has rarely been reported. We herein report on a case of psoriasiform drug eruption that developed after administering imatinib mesylate to treat CML. (Korean J Dermatol 2009;47(5):722∼725)

Goltz 증후군

배유인 ( You In Bae ),윤숙정 ( Sook Jung Yun ),이지범 ( Jee Bum Lee ),김성진 ( Seong Jin Kim ),원영호 ( Young Ho Won ),이승철 ( Seung Chul Lee ) 대한피부과학회 2008 대한피부과학회지 Vol.46 No.1

Goltz syndrome or focal dermal hypoplasia, is a rare genodermatosis, characterized by multiple abnormalities of mesodemal and ectodermal organs. Cutaneous manifestations include linear or cribriform atrophied patches with telangiectasia following Blaschko line and papillomas. The majority of patients also have skeletal abnormalities, such as syndactyly, oligodactyly, scoliosis, and short stature. Furthermore, various ophthalmic and dental manifestations have been reported. We report a case of Goltz syndrome occurring in a 2-year old female with asymptomatic erythematous atrophic patches with purpuric macules and telangiectasia mainly on extremities. She also had hypotrichia on vertex and a notching-like cleft on upper lip. A skin biopsy performed on her atrophic patch on the leg revealed dermal hypoplasia. The final diagnosis was made by typical cutaneous manifestations and histopathological findings compatible with focal dermal hypoplasia. (Korean J Dermatol 2008;46(1):122∼125)

접촉피부염 환자에서 최근 5년간 표준항원 첩포시험 성적

배유인 ( You In Bae ),한정현 ( Jung Hyun Han ),윤숙정 ( Sook Jung Yun ),이지범 ( Jee Bum Lee ),김성진 ( Seong Jin Kim ),이승철 ( Seung Chul Lee ),원영호 ( Young Ho Won ) 대한피부과학회 2009 大韓皮膚科學會誌 Vol.47 No.11

Background: A number of skin manifestations in patients with allergic contact dermatitis result from sensitization with specific allergens. The patch test is a primary diagnostic tool for identifying allergens causing allergic contact dermatitis. Objective: We identified the results of patch test with Korean standard series in patients with clinically diagnosed with contact dermatitis, and evaluated the specific relationship with each allergen. Methods: During a 5-year period, 743 patients were examined with patch test of standard Korean series. The results of patch test were then evaluated. Location of the skin lesion, age, sex, and occupation of the patients were completely reviewed. Results: Overall, 68.5% of patients had at least one positive reaction and 43.6% of patients had two or more positive reactions. Allergens most frequently causing positive reactions were nickel sulfate (27.1%), cobalt chloride (22.1%), potassium dichromate (17.9%), mercuric ammonium chloride (13.8%), and 4-phenyledediamine base (10.2%). Those patients in their 10s and 40s showed the highest rate of positive reaction. Metal allergens displayed higher positive rates than any other standard allergens. Of 201 patients who showed positive reaction to nickel, 37.8% and 27.3% of them also showed positive reaction to cobalt and chromium, respectively, representing concomitant reactions between metal-related antigens. In addition, polysensitization to cosmetics-related antigens including balsam peru and fragnance mix was evident. Conclusion: There was no significant difference in overall positive rate in patch test results compared with recent studies. However, we confirmed that metal-related allergens remain most common, and that multiple contact allergy were relatively common. (Korean J Dermatol 2009;47(11):1227~1235)

홍피증 환자 75명에 대한 임상 역학적 연구

배유인 ( You In Bae ),윤숙정 ( Sook Jung Yun ),이지범 ( Jee Bum Lee ),김성진 ( Seong Jin Kim ),이승철 ( Seung Chul Lee ),원영호 ( Young Ho Won ) 대한피부과학회 2008 大韓皮膚科學會誌 Vol.46 No.2

Background: Erythroderma, a generalized exfoliative dermatitis, is a rare but easily recognized skin condition with the potential for serious outcomes. Various conditions may be associated with the development of erythroderma. Objective: The purpose of this study was to evaluate the prevalence, clinical, laboratory, histopathological findings and evolution of erythroderma and classify the various causes of the disease. Methods: We reviewed medical records, skin biopsy results and clinical photos of 75 patients diagnosed with erythroderma from 1984 to 2006. Results: The male-female ratio was 2.4:1. The mean age at diagnosis was 57 years. 26 out of 75 patients (34.7%) had a history of drug ingestion and a preexisting dermatosis. Nineteen patients (25.3%) remained undetermined. Four patients (5.3%) had concomitant malignancies. In the dermatosis induced group, 10 patients (38.4%) had psoriasis as a possible causative dermatologic disease. Fever (≥38oC) was seen in 28% of patients. Laboratory abnormalities were seen in the order of leukocytosis, eosinophilia, elevated IgE level (>500 IU/ml), elevated erythrocyte sedimentation rate (ESR), elevated lactate dehydrogenase (LDH). There was a significant difference in the proportion of patients showing complete remission to treatment among the groups. In the group of patients who had a recent history of drug ingestion, 42% of patients showed complete remission, whereas the remaining groups, especially the group with preexisting dermatosis displayed only 8% of cases resulting in complete remission (p<0.05). Conclusion: In our view, drug use or pre-existing dermatosis induced erythroderma compose the majority of cases. The differences in response rates among groups may give a more realistic estimation of clinical outcome and provide appropriate guidance to clinicians. (Korean J Dermatol 2008;46(2):202∼208)

다발성 골수종 환자에서 발생한 원발성 전신성 유전분증

배유인 ( You In Bae ),윤숙정 ( Sook Jung Yun ),김성진 ( Seong Jin Kim ),이승철 ( Seung Chul Lee ),원영호 ( Young Ho Won ),이지범 ( Jee Bum Lee ) 대한피부과학회 2007 대한피부과학회지 Vol.45 No.12

Primary systemic amyloidosis is associated with plasma cell dyscrasia, such as multiple myeloma. The amyloid fibrils in the disease are composed of amyloid light (AL) protein that is derived from immunoglobulin L chain. Cutaneous manifestations are presented in about 20∼40% of patients with mainly petechia, purpura on flexural area of the body and waxy, translucent papulonodules. We report a case of primary systemic amyloidosis associated with multiple myeloma occurring in a 76-year old woman who had suffered from ecchymotic purpura on periorbital and flexural area with hemorrhagic bulla for one year. She also had macroglossia with grouped papulonodules on her tongue, and peripheral neuropathy. The final diagnosis was confirmed by positive PAS, Congo-red stain and specific serum/urine electrophoresis. She had been treated with several cycles of chemotherapy; however, she expired from various complications of the disease, such as congestive heart failure, renal failure, and secondary bacterial infection. (Korean J Dermatol 2007;45(12):1275∼1279)

노인관광객의 시간지향성과 기억에 남는 관광경험 간 관계 분석

배유리 ( Bae Yu-ri ),이유하 ( Lee You-ha ),이봉구 ( Lee Bong-koo ) 동북아관광학회 2021 동북아관광연구 Vol.17 No.1

시간지향성은 인간행동의 다양한 측면에 있어 중요한 역할을 담당한다. 최근 관광기업/관광지의 경쟁력을 강화할 수 있는 대안으로 노인관광시장과 기억에 남는 관광경험 제공 중요성이 강조되고 있다. 본 연구는 노인관광시장의 시간관과 기억에 남는 관광경험 사이의 관계를 고찰할 목적으로 수행되었으며, 이를 위해 편의추출법과 눈덩이 표집법을 통해 선정한 29명을 대상으로 2018.4.23.~5.16. 사이에 심층인터뷰를 실시하였다. 응답자들이 기억한 관광경험은 총 365건이었으며, 이는 31개의 범주와 16개의 차원으로 유형화되었다. 본 연구의 주요 결과는 첫째, 응답자들은 방문지의 생소한 생활상, 방문지의 경이로운 자연경관, 특이한 사람들, 고생한/곤경에 처한 순간들, 여행 중 느꼈던 긍정적 감정 등과 관련된 경험은 상대적으로 많이 기억한 반면, 방문지의 실망스런 자연경관, 여행을 통해 얻은 지식, 방문지의 걸출한 문화유산, 삶의 의미에 대한 사색 등과 관련된 경험에 대한 기억은 미미한 것으로 나타났다. 둘째, 응답자들의 시간지향성과 기억하고 있는 관광경험 간에는 유의한 연관성이 있는 것으로 나타났다. 본 연구 결과가 가지는 이론적ㆍ실무적 시사점, 연구의 한계, 그리고 향후 연구과제에 대해 논의하였다, Time orientation plays a key role in various aspects of human behaviors. Recently both targeting senior tourist market and providing memorable tourist experience have suggested as alternatives to enhance competitiveness and sustainability of tourist businesses/tourist destinations. This study aimed to investigate the relationship between senior tourists’ time orientation and their memorable tourist experiences(MTEs). In-depth interviews of 29 respondents, selected from convenient and snow-balling sampling methods, were implemented from April 23, 2018 to May 16. A total of 365 MTEs was identified from respondents’ responses and grouped into 31 categories and 16 sub-dimensions. Major findings were: first, relatively frequently mentioned MTEs included different ways of life, wonderful natural scenery, unique persons, moments of hardships/troubles, and positive emotions felt; however, such experiences as disappointing natural scenery, knowledge learnt from travel, outstanding cultural heritages, and meditating meanings of life were occasionally remembered. Second, the relationship between senior tourists’ time orientation and their MTE was statistically meaningful. Both theoretical and practical implications, research limitations, and future research directions were discussed.

삼각형 간섭계를 이용한 Incoherent 홀로그래피의 수치적 재생에 관한 연구

배유석(You - Seok Bae),이혁(Hyuk Lee) 대한전기학회 1994 대한전기학회 학술대회 논문집 Vol.1994 No.11

중년 이후 양측 안검부에 대칭으로 발생한 면포 모반

배유인 ( You In Bae ),심지훈 ( Ji Hoon Sim ),양정훈 ( Jung Hoon Yang ),이상훈 ( Sang Hoon Lee ),황규왕 ( Kyu Uang Whang ),박영립 ( Young Lip Park ) 대한피부과학회 2012 대한피부과학회지 Vol.50 No.4

Nevus comedonicus is a relatively rare hamartoma, which originates from pilosebaceous unit. The disease usually occurs at birth or during childhood and most commonly unilateral or along with Blascko line. A 59-year-old man presented with black grouped dilated pores, with keratin plug on both eyelids. A histopathologic finding showed multiple keratin filled epidermal invaginations. We herein report an unusual case of bilateral nevus comedonicus developed in middle aged persons. (Korean J Dermatol 2012;50(4):346∼349)