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눈가리개(Eye Mask) 형태의 얼굴 발진과 모세혈관확장증을 보인 신생아 홍반루푸스
심지훈 ( Ji Hoon Sim ),김윤지 ( Yoon Ji Kim ),배유인 ( You In Bae ),황규왕 ( Kyu Uang Whang ),박영립 ( Young Lip Park ),이상훈 ( Sanghoon Lee ) 대한피부과학회 2012 대한피부과학회지 Vol.50 No.11
Neonatal lupus erythematosus (NLE) is an autoimmune disease associated with the maternal anti-SSA/Ro and anti-SSB/La antibodies. NLE is characterized by cutaneous erythema, congenital heart block (CHB), hepatic dysfunction and hematological abnormalities. The characteristic cutaneous lesion is an annular or polycyclic erythematous patch or plaque. Individual annular lesions are often about 1 cm in diameter. We report a case of NLE in a 7-day-old female infant, born of a clinically asymptomatic mother, presenting “eye mask” shape rash and telangiectasia on her face. Periorbital rash with “eye mask” appearance presents in a few of NLE cases, and this cutaneous sign has been emphasized as a diagnostic clue to NLE. Her serological tests revealed high titers of anti-SSA/Ro, anti-SSB/La and antinuclear antibody. Based on these clinical and serological findings, the patient was diagnosed as NLE with characteristic periorbital skin findings. (Korean J Dermatol 2012;50(11):974∼977)
심지훈 ( Ji Hoon Sim ),양정훈 ( Jung Hoon Yang ),이성열 ( Sung Yul Lee ),조문균 ( Moon Kyun Cho ),배유인 ( You In Bae ),이상훈 ( Sang Hoon Lee ) 대한피부과학회 2011 대한피부과학회지 Vol.49 No.3
Pachyonychia congenita (PC) is characterized by hypertrophic nail dystrophy, focal palmoplantar keratoderma and blistering, oral leukokeratosis, cyst formation, palmoplantar hyperhydrosis, and follicular keratoses on the trunk and extremities. PC is diagnosed by clinical findings and molecular genetic studies. A 26-year-old man presented with hypertrophic nail dystrophy and subungual debris of all 20 nails, hyperkeratotic plaques on the heels of both soles, and oral leukokeratosis. He had no family history of similar clinical findings. The patient`s clinical presentation and history were consistent with PC. Herein we report on a rare case of pachyonychia congenita with a review of literature. (Korean J Dermatol 2011;49(3):265∼268)
심지훈 ( Ji Hoon Sim ),신정웅 ( Jung Woong Shin ),김형동 ( Hyung Dong Kim ),박영립 ( Young Lip Park ),이종석 ( Jong Suk Lee ),황규왕 ( Kyu Uang Whang ) 대한피부과학회 2011 대한피부과학회지 Vol.49 No.6
Angiosarcoma is a rare malignant tumor of an endothelial cell derivation and it accounts for less than 2% of all sarcomas. It is a highly aggressive neoplasm with a poor prognosis and most patients die within a short period after presentation. Although angiosarcoma may occur in any location on the body, it rarely arises from major vessels, but has a decided predilection for the skin and superficial soft tissue. A 39-year-old man was referred to our department with an asymptomatic, firm, ulcerative nodule on his scalp that was noticed almost 2 months previously. He had been diagnosed with lung angiosarcoma 9 month earlier. Histopathologically, the skin specimen showed angiosarcoma. The histological findings of the metastatic skin cancer are usually the same as that of the primary cancer. Metastatic cutaneous angiosarcoma is uncommon. Based on these clinical and histopathological findings, our case seems to be skin metastasis at the scalp from the lung angiosarcoma. (Korean J Dermatol 2011;49(6):520∼523)
심지훈 ( Ji Hoon Sim ),이건홍 ( Gun Hong Lee ),김형동 ( Hyung Dong Kim ),이성열 ( Sung Yul Lee ),박영립 ( Young Lip Park ),황규왕 ( Kyu Uang Whang ) 대한피부과학회 2011 대한피부과학회지 Vol.49 No.11
Carcinoid tumors are derived from enterochromaffin cells that are capable of producing a wide range of neuroendocrine mediators including serotonin or 5-hydroxytryptamine. Carcinoid syndrome occurs when mediators produced by the tumor and normally metabolized by the liver escape into the systemic circulation. The syndrome classically involves the gastrointestinal tract, respiratory system, cardiovascular system and the skin. Flushing is almost universal in the syndrome. A 23-year-old woman came to our hospital presenting with flushing on face and trunk. The patient had experienced flushing for 2 years and it was aggravated by emotional change, stress, exercise, and eating spicy food. The patient also had abdominal pain, diarrhea, weight loss and hepatomegaly. Urinary 5-hydroxyindoleacetic acid was elevated (81.5 mg/day). Abdominal computed tomography scans showed multiple hepatic masses diagnosed as a carcinoid tumor by computed tomography-guided needle biopsy. Physicians should consider carcinoid syndrome when patients present with flushing and systemic symptoms. (Korean J Dermatol 2011;49(11):1006∼1009)
내분비 내과를 내원한 고령자들의 피부질환 분포와 피부 관리 행태에 대한 조사
심지훈 ( Ji Hoon Sim ),이종석 ( Jong Suk Lee ),이성열 ( Sung Yul Lee ),김상진 ( Sang Jin Kim ) 대한피부과학회 2013 대한피부과학회지 Vol.51 No.1
Background: Advances in medicine and improved overall standard of living have brought people`s attention to living a long healthy life. As a consequence, geriatric medicine is now gaining more and more attention in the field of medicine and dermatology is no exception. Objective: The aim of this study was to examine features of the elderly in terms of the prevalence of dermatosis and general and medical skin care patterns. Methods: A detailed survey and complete physical examination were performed on 525 patients aged over 65, who were treated at the endocrinology center at our hospital, from January to December 2011. Results: The elderly gained most information on dermatologic diseases from their families and neighbors. The most common dermatologic disorder was senile lentigo (85.5%), followed by seborrheic keratosis (69.0%), xerosis cutis (63.0%), generalized pruritus (42.3%), onychomycosis (30.3%), and cherry angioma (26.9%). Furthermore, xerosis cutis was more often found in older patient groups among the elderly. When it comes to general skin care, one third of the elderly used moisturizers and 10.7% used sunscreens. Only 1.3% of the elderly received medical skin care. Conclusion: This study can be used as useful baseline data not only for the government to formulate a national health care plan but for each medical center to understand dermatologic disorders of the elderly and educate its staff members on the management of dermatologic problems of the elderly. (Korean J Dermatol 2013;51(1):1∼7)
1% Pimecrolimus 국소 도포로 치료한 Keratosis Follicularis Squamosa (Dohi)
이강모 ( Gang Mo Lee ),심지훈 ( Ji Hoon Sim ),배유인 ( You In Bae ),이성열 ( Sung Yul Lee ),박영립 ( Young Lip Park ),이상훈 ( Sang Hoon Lee ) 대한피부과학회 2013 대한피부과학회지 Vol.51 No.7
Keratosis follicularis squamosa (Dohi) is a keratinizing disorder which is a separate clinical entity from keratosis follicularis (Darier`s disease). It occurs predominantly in Japanese and appears clinically as scaly patches of 3∼10 mm in diameter with brownish follicular plugs in the center, which are symmetrically scattered on the trunks and thighs. Scales on the margin, slightly detached from the underlying epidermis, look like ``lotus leaves on the water``. The efficacy of minocycline has already been confirmed in many cases. In this report, we describe a case of using 1% of pimecrolimus cream for keratosis follicularis squamosa (Dohi) instead of minocycline. (Korean J Dermatol 2013;51(7):556∼559)
배유인 ( You In Bae ),심지훈 ( Ji Hoon Sim ),양정훈 ( Jung Hoon Yang ),이상훈 ( Sang Hoon Lee ),황규왕 ( Kyu Uang Whang ),박영립 ( Young Lip Park ) 대한피부과학회 2012 대한피부과학회지 Vol.50 No.4
Nevus comedonicus is a relatively rare hamartoma, which originates from pilosebaceous unit. The disease usually occurs at birth or during childhood and most commonly unilateral or along with Blascko line. A 59-year-old man presented with black grouped dilated pores, with keratin plug on both eyelids. A histopathologic finding showed multiple keratin filled epidermal invaginations. We herein report an unusual case of bilateral nevus comedonicus developed in middle aged persons. (Korean J Dermatol 2012;50(4):346∼349)