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배완수 대한마취과학회 1968 Korean Journal of Anesthesiology Vol.1 No.1
CI-581(a phencyclidine derivative), a new potent, short-acting nonbarbiturate was administered to 101 patients, ranging in age from 2 months to 68 years, either intravenously, intramuscularly, or by a combination of the two routes. An intravenous dose of 1 to 2 mg per kg of body weight produced surgical anesthesia within 30 seconds, and adequate operating condition lasted for 5 to 20 minutes. With the onset of anesthesia, eyes usually opened and extremities became relaxed. However, pharyngeal and laryngeal reflexes re- mained active, and airway remained pater.t without benefit of manual support or the insertion of a mechanical airway. The pulse rate usually increased and the blood pressure rose sometimes to undesirable levels following intravenous administration. To achieve surgical anesthesia by intramuscular route a dose of 5 to 10 mg per kg was required. Surgical anesthesia developed in 3 to 5 minutes and lasted for 20 to 30 minutes. Some of the patients remembered the experience of dream which was of colorful and cheerful na- ture. There was no serious postoperative complications. CI-581 seemed useful to produce anesthesia for short procedures particularly in infants and children with intramuscular administration.
망상어 (Ditrema temmincki Bleeker)의 방광(膀胱)에 대(對)한 자율신경제(自律神經劑)의 작용(作用)
배완수,Bae, Wan-Soo 대한약리학회 1969 대한약리학잡지 Vol.5 No.2
The author studied the action of autonomic drugs on the urinary bladder isolated from Ditrema temmincki Bleaker and the results obtained were summarized as follows: 1) The motility of the urinary bladder of the fish was stimulated by acetylcholine and physostigmine. The stimulating action of these drugs was antagonized by atropine. 2) The motility of the fish bladder was stimulated by epinephrine, nor-epinephrine and phenylephrine, but inhibited by isoproterenol. 3) The inhibitory effects of isoproterenol on the fish bladder was not affected by phenoxybenzamine, but blocked by propranolol. 4) The excitatory effects of phenylephrine on the fish bladder were blocked by phenoxybenzamine, but augmented by propranolol. 5) The excitatory effects of epinephrine and nor-epinephrine were reversed by phenoxybenzamine and augmented by propranolol. 6) The motility of the fish bladder pretreated with phenoxybenzamine and propranolol was not affected by isoproterenol, phenylephrine, epinephrine and nor-epinephrine. 7) It seemed that the bladder muscle of the fish had both alpha excitatory and beta inhibitory receptors. 8) The motility of the fish bladder was stimulated by nicotine and DMPP. The excitatory effects of these drugs were abolished by pretreatment with hexamethonium or atropine. 9) It is, therefore, concluded that there are ganglion cells furnished with cholinergic fiber in the bladder wall of the fish.
배완수,박영달 대한마취과학회 1971 Korean Journal of Anesthesiology Vol.4 No.1
Maternal and feta! effects of anesthesia for 100 Cesarean sections, performed during the past two-and-half year period in this hospital, have been evaluated. It is emphasized that the selection of anesthetic agent and method should depend upon the physical status of the patients and the ability of both obstetrician and anesthesiologists.
배완수,박영달 대한마취과학회 1972 Korean Journal of Anesthesiology Vol.5 No.2
To two patients suffering from intractable upper abdominal pain associated with recurrent carcinomatosis following previous gastrectcmy, 10 per cent saline solution was administered through an indwelling epidural (T 7-8) catheter. The results are as follows: 1) The method effectively relieved the pain in both patients. 2) The durations of pain relief were variable. It is noteworthy, however, that the method is. remarkably effective in relieving intractable pain associated with incurable malignancies. 3) The pain accompanying saline injection could be modified by prior administration of xylocaine through the same catheter. 4) The method was simple without complications, hence ambulatory application was possible.