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불면증 환자에서 수면시간에 대한 주관적 지각과 객관적 소견의 불일치
김하현(Ha-Hyun Kim),배경렬(Kyung-Yeol Bae),김성완(Sung-Wan Kim),김재민(Jae-Min Kim),신일선(ll-Seon Shin),김선영(Seon-Young Kim),윤진상(Jin-Sang Yoon) 대한생물치료정신의학회 2012 생물치료정신의학 Vol.18 No.2
Objectives:Polysomnography in insomnia patients has often revealed a mismatch between the subjective perception and the objective findings of sleep time. We aimed to examine this mismatch and investigate the characteristics associated with the mismatch in insomnia patients. Methods:In 121 insomnia patients, findings of nocturnal polysomnography, responses to a subjective questionnaire after sleep, and medical records were reviewed. The patients were classified into two groups-total sleep time (TST) underestimation group(N=56) and TST non-underestimation group(N=65)-depending on the presence of a 2-h difference between the subjective and the objective TSTs. The demographic characteristics, type of insomnia, use of sleep-promoting medication, polysomnography findings, and subjective reports were compared between the two groups. Results:Nocturnal polysomnography showed significantly longer TST(p<0.001) and shorter sleep latency(p< 0.001) than the subjectively reported values. In comparison with the TST non-underestimation group, the TST underestimation group were significantly older(p=0.043) ; more likely to have longer TST(p=0.012), shorter sleep latency (p=0.002), and a smaller proportion of slow-wave sleep(p<0.001) in the polysomnographic analysis ; and more likely to show shorter TST(p<0.001) and shallower sleep(p<0.001) in the subjectively reported values. Conclusions:We found a significant mismatch between the subjective perception and the objective findings of sleep time as determined using polysomnography in insomnia patients. Underestimation of sleep time may be more closely associated with the proportion of slow-wave sleep, which reflects sleep depth, than with objective TST.
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김석헌(Seok-Heon Kim),김선영(Seon-Young Kim),배경렬(Kyung-Yeol Bae),김성완(Seong-Wan Kim),김재민(Jae-Min Kim),신일선(ll-Seon Shin),윤진상(Jin-Sang Yoon) 대한생물치료정신의학회 2012 생물치료정신의학 Vol.18 No.2
Background and Aims:Relatively few studies have explored the quality of life(QOL) in mild cognitive impairment (MCI) and Alzheimer’s disease(AD). This study aimed to compare the QOL in MCI with that in AD. Methods:24 normal controls, 29 mild MCI patients, 20 AD patients, and their caregivers participated. QOL was assessed using the Korean version of QOL-AD(KQOL-AD). Korean version-Mini Mental State Examination(K-MMSE), Activities of Daily Living(ADL), Clinical Dementia Rating(CDR), and Neuropsychiatric Inventory(NPI) were also used to assess the participants. Results:Both patient and caregiver-reported QOL scores of AD group were lower than those of MCI and control groups. However, there were no significant differences among the three groups in QOL(p=0.069, p=0.058). Patientreported QOL scores of all participants showed were significant negative correlations with ADL scores and NPI scores, but not with K-MMSE scores(r=-0.316, p=0.009 ; r=-0.349, p=0.010 ; and r=0.094, p=0.430). Caregiverreported QOL scores of all participants showed significant negative correlations with ADL scores and NPI scores, but not with K-MMSE scores(r=-0.369, p=0.015 ; r=-0.413, p=0.007 ; and r=0.147, p=0.341). Conclusion:Both patient-reported and caregiver-reported QOL scores of AD patients were not significantly different from those of MCI patients and normal controls. NPI and ADL scores were negatively associated with QOL, while K-MMSE scores were not. Thus, therapeutic strategies for behavioral and psychological symptoms of MCI and AD will be need to improve patient QOL.
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폐쇄성 수면무호흡증 환자에서 하지불안증후군과 우울, 불안 및 불면과의 연관성
김주완(Ju-Wan Kim),김성완(Sung-Wan Kim),김재민(Jae-Min Kim),신일선(ll-Seon Shin),윤진상(Jin-Sang Yoon),배경렬(Kyung-Yeol Bae) 대한생물치료정신의학회 2016 생물치료정신의학 Vol.22 No.3
Objectives:An association between obstructive sleep apnea syndrome(OSAS) and restless legs syndrome(RLS) has long been reported. Both syndromes are associated with depression, anxiety, insomnia, and daytime sleepiness. However, these relationships have not been studied extensively, and many questions remain unanswered. This study investigated the prevalence of RLS and its association with depression, anxiety, insomnia, and daytime sleepiness in OSAS patients in Korea. Methods:The study enrolled 152 Korean OSAS in patients Chonnam National University Hospital. The International Restless Legs Syndrome Study Group criteria and International Restless Legs Scale were used to determine the diagnosis and severity of RLS. To assess depression, anxiety, insomnia, and day time sleepiness, all patients completed the Beck Depression Inventory(BDI), Beck Anxiety Inventory(BAI), Insomnia Severity Index(ISI), and Epworth Sleepiness Scale(ESS). Results:Overall, 65(42.6%) patients met least one of the RLS diagnostic criteria, and 17(11.1%) were diagnosed with RLS. The mean BDI, BAI, and ISI scores were higher in subjects with RLS symptoms compared with those without such symptoms. ESS scores were not significantly associated with RLS symptoms. There were significant positive correlations between RLS severity and BDI(r=0.246, p=0.049), BAI(r=0.247, p=0.031), and ISI(r=0.275, p=0.026) scores. Conclusion:There were significant relationships between RLS symptoms and depression, anxiety, and insomnia. We recommend that patients with OSAS be evaluated for symptoms of RLS.
KCI
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