안구증상과 면역이상을 동반한 아토피 피부염 2예

박천욱(Chun Wook Park),최성우(Sung Woo Choi),주은희(Eun Hee Choo),고익준(Ik Jun Ko),김형옥(Hyung Ok Kim),김정원(Chung Won Kim) 대한피부과학회 1984 대한피부과학회지 Vol.22 No.6

The relation of atopic dermatitis to various manifestations of ocular disease has been documented in the dermatologic literature. Several lines of evidence suggest that patients with atopic dermatitis have defective ceil-mediated immunity and decreased cellular hypersensitivity. In this paper, we presented two cases of atopic dermatitis developing ocular complication and abnormal immune response in vivo and in vitro during the course of atopic dermatitis.

수종 피부질환에서 회상 항원들에 의한 피부지연 면역반응

박천욱(Chun Wook Park),최성우(Sung Woo Choi),김형옥(Hyung Ok Kim),김정원(Chung Won Kim) 대한피부과학회 1985 대한피부과학회지 Vol.23 No.4

Authors have performed patch test to evaluate the differences between the allergic contact dermatitis to topical medicaments and to the other substances including cosmetics. One hundred eighteen patients were evaluated according to age, sex, and causative agents of the disease. Furthermore, these patients were analysed as to the causative allergic contact factors by clinical inspection and history. The most common causative allergic contact factors by clinical, history and patch test were topical medicarnents(45.8%), cosmetics(24. 6%), rubbery(10.2%), and metals(8.59%.). The common etiogloic medicaments of contact dermatitis were Madecassol, Betadin, Tiger balm, Canesten, Mercurochrom, and Tego solution. The causative agents were confirmed by the patch test with Hollister-Stiers standard allergens in 57 patients from Jan. 1983 to Dec. 1984, 1 hirty eight among 57 patients were positive to patch test, Back ground possible explanation of the patch test results were discussed and a comparison was made between this report and others.

미만성 구간 혈관각화종

최성우(Sung Woo Choi),박천욱(Chun Wook Park),주은희(Eun Hee Choo),최국주(Guk Joo Choi),김형옥(Hyung Ok Kim),김정원(Chung Won Kim),송계용(Kye Yong Song) 대한피부과학회 1984 대한피부과학회지 Vol.22 No.5

Thymopentin으로 치험한 아토피피부염 2예

이경열 ( Kyung Ywal Lee ),우준하 ( Jun Ha Woo ),박천욱 ( Chun Wook Park ),이철헌 ( Cheol Heon Lee ) 대한피부과학회 1996 대한피부과학회지 Vol.34 No.4

The pat,hogenesis of atopic dermititis(AD) is still undefined. The prominent immunologic abnormalities associated with AD are defective cell-mediated immunity and increased IgE production. Also, the predominant CD4 subset in the skin lesion of AD is a Th2-like. Thymopentin, the active pentapepide of a thymic hormone, promotes differentiation of thymocytes and exhibits immunomodulating function. We experienced 2 case. of severe AD patients who were treated with subcutaneous injection of thymopentin three times a week for 6 weeks or 8 weeks. We compared the effects of cyclosporine A(CsA), FK -506 and thymopentin on the production of IL-2, IL-3, IL-4 and sIL-2R in vitro. In patient 1, there was no clinical response with thymopentin therapy. There was no difference in the serum IgE levels between before and after treatment. The ratio of Th/Ts was increased after treatment. In vitro study, CsA and FK-506 inhibited the production of IL-2, IL-3, IL 4 and sIL-2R, and thymopentin inhibited the production of IL-2, IL-3, IL-4 and sIL-2R. In patient 2, the clinical score of the patient was improved from 15 to 10 after treatment with thymopentin. There was no difference in the serum IgE level. The ratio of Th/Ts was decreased after treatment. In vitro study, the production of IL-2, IL-3 and IL-4 were decreased in lymphocytes added with CsA and FK-506, but the production of sIL-2R was increased by CsA and FK-506. Also, the production of IL-3 and IL-4 were increased in lymphocytes added with thyrnopentin, but the proluction of IL-2 and sIL-2R were increased by thymopentin. Our data suggest that thymopentin could be effective in the treatment of severe AD through the upregulation of Thl-like subset, not via the downregulation of Th2-like subset. (Kor J Dermatol 1996;34(4): 668-672)

아토피피부염학회 보고서: 한국 아토피피부염의 치료지침

이지현 ( Ji Hyun Lee ),김규한 ( Kyu Han Kim ),김명남 ( Myeung Nam Kim ),김진우 ( Jin Woo Kim ),노영석 ( Young Suck Ro ),박영립 ( Young Lip Park ),박천욱 ( Chun Wook Park ),이광훈 ( Kwang Hoon Lee ),이애영 ( Ai Young Lee ),조상현 ( 대한피부과학회 2006 대한피부과학회지 Vol.44 No.8

Background: Atopic dermatitis is a chronic, relapsing, inflammatory skin disease, with genetic and environmental background. Successful management of atopic dermatitis requires a multipronged approach. However, standardized guidelines for the management of Korean atopic dermatitis patients do not exist. Objective: This study was performed to provide a standardized treatment guideline for atopic dermatitis in Korea. Methods: On the basis of treatment guidelines proposed by the ADRG (Atopic Dermatitis Research Group), we consider the characteristic provocation factors reported in previous Korean cases and the new modalities which have recently been introduced. Results: Management should compromise of a disease-adapted treatment which combines adjuvant basic therapy, symptomatic relief and, if needed, anti-inflammatory treatment and the identification and avoidance of trigger factors. New therapies such as topical calcineurin inhibitors are also considered to be good alternatives for the long-term control of atopic dermatitis. Conclusion: The algorithm contained within the article was presented as the basis for a guideline of clinical practice that could be used to facilitate the treatment of atopic dermatitis at any stage in Korea. (Korean J Dermatol 2006;44(8):907~913)

희귀한 부위, 유두에서 발생한 사마귀모양암 1예

정민재 ( Min Je Jung ),김혜원 ( Hye One Kim ),강석영 ( Seo Young Kang ),김진철 ( Jin Cheol Kim ),정보영 ( Bo Young Chung ),박천욱 ( Chun Woo Park ) 대한피부과학회 2021 대한피부과학회지 Vol.59 No.3

Verrucous carcinoma is a rare, low-grade, well-differentiated variant of squamous cell carcinoma. It occurs mainly on the soles, but has also been reported in other locations, including the buttocks, hand, anus, and genitalia. A 38-year-old woman presented with an asymptomatic skin lesion of the nipple. She first noticed the lesion three months prior. A solitary, cauliflower-shaped, black polypoid mass was observed on her right nipple. Histopathological examination revealed a superficial lesion resembling verruca vulgaris. It was composed of relatively well-differentiated cells with severe epidermal proliferation, and some tumor cells were observed in the dermis. The final diagnosis was verrucous carcinoma. Complete excision of all the lesions was performed. The patient had no recurrence. We report an interesting case of verrucous carcinoma that occurred at a relatively rare site; only one previous report of verrucous carcinoma associated with the breast or nipple was found. (Korean J Dermatol 2021;59(3):234∼236)

Cephalosporin계에 의한 접촉 피부염 1예

이철헌,박천욱,우준하,신경열 대한피부과학회 1998 大韓皮膚科學會誌 Vol.36 No.6

Cephalosporins are B-lactam antibiotics. They are usually bactericidal in action and act by inhibiting mucopeptide synthesis in the bacterial cell wall. Cephalosporins have been used widely in Korea. However, allergic contact dermatitis to cephalosporins has not been reported in the Korean dermatologiy literature. We report a case of allergic contact dermatitis due to cephalosporins in a 23-year-old nurse who suffered from itchy, erythematous patches and plaques with numerous fissures on both hands. A patch test with ceftriaxone and a prick test with cefotiam were positive.

Cytokeratin Expression in Seborrheic Keratosis

김종민,이철헌,박천욱,우준하 대한피부과학회 1997 Annals of Dermatology Vol.9 No.2

Background : Using biochemical and immunohistochemical studies, alterations of cytokeratin expression has been reported in seborrheic keratosis. Objective : To further investigate the cytokeratin expression in seborrheic keratosis, we have done immunohistochemical staining using a panel of specific anti-keratin antibodies in this study. We also observed the cytokeratin expression in the hair, sebaceous gland and sweat gland of the some epidermis. Methods : Twenty cases of seborrheic keratosis were collected from the pathologic files. The histological types included acanthotic type (13 cases), hyperkeratotic type (5 cases), and pigmented type (2 cases). All tissues had been fixed in formalin and then paraffin-embedded according to conventional procedures. Each section was mounted on a gelatin-coated glass slide, and incubated with various anti-keratin antibodies. The sections were then immunostained using the avidin-biotin-peroxidase complex system. The peroxidase reaction was visualized with diaminobenzidine (DAB). Results : 1. Cytokeratin expression in seborrheic keratosis lesions On staining with 34βB4 (K1), several staining patterns in the suprabasal layers of the epidermis were observed in 10 out of 20 cases. Using the AE1 (K10, 14, 15), we observed focal staining in 2 cases. We observed several positive staining patterns in 5 cases with K13, 16 antibody. On staining with K10 antibody, we observed focal or irregular staining patterns in 14 cases. Focal staining was also observed with K5, 8 antibody in one case. 2. Cytokeratin expression in the hair, sebaceous gland and sweat gland On immunoperoxidase staining of hair, there were positive reactions with CAM5.2 (K8, 18) in 2 cases. There were positive reaction with K13, 16 antibody in one case, with 34βB4 (K1), and K10 antibody in 3 cases, and with K17 antibody in 2 cases. On immunoperoxidase staining of sebaceous glands, there was one positive reaction with CAM5.2 (K8, 18) in the suprabasal cells of sebaceous glands and with K13, 16 antibody in sebaceous ducts. There were positive reactions with K17 antibody in the sebaceous ducts in 2 cases, and with K 1 antibody in the sebaceous glands in one case. Using 34βB4 (K1), 4 out of 20 cases showed positive reactions in sweat glands. On staining with AE1 (K10, 14, 15), positive reactions were observed in 8 cases. Staining with CAM5.2 (K8, 18) showed positive reactions in 14 cases. There were positive reactions with K19 antibody in 9 cases. Conclusion : Our data suggests that the predominant keratin expression in the tumor cells of seborrheic keratosis is high molecular weight keratin (K1/K10) rather than other lower molecular weight keratin. Tumor cells show some proliferative activity and monoclonal antibody K19 could be a marker for eccrine sweat glands like CAM5.2 (K8, 18).