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Potential Imaging Biomarkers of Cognitive Frailty
박재섭,김우정 대한노인병학회 2023 Annals of geriatric medicine and research Vol.27 No.1
Cognitive frailty (CF) is a state of impairment in both cognitive and motor functions. The concept of CF has been developed in several ways. However, it is difficult to identify consistent neuroimaging findings according to the application of the operational definition of different frailty models within the same concept, as well as the diversity of the concept itself of CF. This study aimed to review neuroimaging studies of CF and to determine suitable imaging biomarkers of CF. White matter abnormalities (e.g., white matter hyperintensity and microbleeds) seem likely to be considered imaging biomarkers of CF. The volume of the cerebral/cerebellar cortex and that of the subcortical nuclei are also candidates of imaging biomarkers of CF. These imaging biomarkers are expected to be more useful in discriminating the need for screening CF in visitors of clinics or health examination centers than in detecting the presence of CF in community-dwelling older adults.
섬망 관련 염증표지자로서 호중구-림프구비의 임상적 활용 가능성에 대한 탐색적 연구
박재섭,양소영,박선영,송정은 한국정신신체의학회 2021 정신신체의학 Vol.29 No.2
Objectives:Delirium is a temporary brain dysfunction and systemic inflammation is important factor in its pathophysiology. Whether the neutrophil-lymphocyte ratio (NLR), one of the inflammatory markers, can be used as an inflammatory marker in delirium patients was investigated in comparison with C-reactive protein (CRP). Methods:We retrospectively reviewed the medical records of patients who were referred for consultation for delirium at hospital for one year. The NLR and CRP values at admission and delirium status were divided into the medical and the surgical treatment group, and the interaction between them was analyzed through repeated measures ANOVA. Results:NLR was maintained without significant difference before and after delirium in the medical treatment group and the surgical treatment group, but CRP decreased in the medical treatment group and increased in the surgical treatment group during delirium, showing a significant interaction. Conclusions:In delirium patients, the NLR remained constant, but the CRP differed according to the treatment group and the delirium state. This suggests the possibility that NLR could be used complementary to CRP as an inflammatory marker in delirium patients. 연구목적: 섬망은 뇌 기능의 일시적 장애로 전신 염증반응이 위험 요인으로 알려져 있다. 염증지표 중 하나인 호중구- 림프구비(neutrophil-lymphocyte ratio, NLR)가 섬망 환자에서 염증지표로 활용 가능할지 C반응 단백질(Creactive protein, CRP)과의 비교를 통해 탐색하였다. 방 법: 일병원에서 1년간 섬망으로 협의진료한 환자의 의무기록을 후향적으로 검토하였다. 치료 방법에 따라 내과적 치료군과 수술적 치료군으로 나누어 입원시와 섬망시의 NLR과 CRP 값을 확인하였고, 반복측정 분산분석을 통해 이들 사이의 상호작용을 확인하였다. 결 과: 검사 종류, 측정시기, 치료군간 유의한 상호작용을 보였다. CRP는 수술적 치료군에서는 입원시에 비해 섬망일 때 증가하였으나 내과적 치료군에서는 감소하였다. NLR은 두 군 모두에서 입원시와 섬망시에 유의한 차이를 보이지 않았다. 결 론: 섬망환자에서 NLR은 일정하게 유지되었으나 CRP는 치료군 및 섬망 유무에 따라 변화하는 양상을 보였다. 이는 NLR이 섬망 환자의 염증지표로 CRP와 상호보완적으로 활용될 가능성을 시사한다.
박재섭,Seung-Taek Oh,Sunyoung Park,Won-Jung Choi,Cheung Soo Shin,Se Hee Na,김재진,오주영,박진영 대한중환자의학회 2018 Acute and Critical Care Vol.33 No.1
Background: Delirium is common among intensive care unit (ICU) patients, so recent clinical guidelines recommended routine delirium monitoring in the ICU. But, its effect on the patient’s clinical outcome is still controversial. In particular, the effect of systems that inform the primary physician of the results of monitoring is largely unknown. Methods: The delirium notification program using bedside signs and electronic chart notifications was applied to the pre-existing delirium monitoring protocol. Every patient was routinely evaluated for delirium, pain, and anxiety using validated tools. Clinical outcomes, including duration of delirium, ICU stay, and mortality were reviewed and compared for 3 months before and after the program implementation. Results: There was no significant difference between the two periods of delirium, ICU stay, and mortality. However, anxiety, an important prognostic factor in the ICU survivor’s mental health, was significantly reduced and pain tended to decrease. Conclusions: Increasing the physician’s awareness of the patient’s mental state by using a notification program could reduce the anxiety of ICU patients even though it may not reduce delirium. The results suggested that the method of delivering the results of monitoring was also an important factor in the success of the delirium monitoring program.
한류영화에서의 ‘민족’ 담론 연구 -영화 『나의 결혼원정기』를 중심으로-
박재섭 한국언어문화교육학회 2007 언어와 문화 Vol.3 No.2
Park, Jae-sup. 2007. The Discourses of Nationalism in ‘Korean Wave(Halliu)’ Movies -Centering on the movie ‘my Wedding Campaign’. The Language and Culture 3-1: 141-154. The Language and Culture......The heroes, Man-taek and Hee-cheol are 38-year-old single men. Man-taek is a simple farmer still living with his mother. He is too naive to even catch a girl’s eye. Man-taek’s best friend Hee cheol is a impudent taxi driver but actually he’s also a pathetic single man. Suffering difficulties to find the brides to marry, the two friends decide to leave for Uzbekistan in search of their soul mates. There, Man-taek meets a North Korean defector, Lara who is a smart local interpreter, and they rejoin in South Korea while Hee-Cheol marrying Alonya, a ‘‘Koryosaram’ (Korean living in Uzbekistan). This movie is partly successful in portraying the pain and loneliness of those living in the peripheries of the world by making good use of familiar rural reality and Uzbekistan’s foreign landscapes. But the movie still advocates pure-blood nationalism, which is repeating a recipe that ‘Korean wave(halliu)’ movies borrow. A protagonist from one side of the divided Korean Peninsula and an antagonist from the other, their fates tragically or comically entangled. The plot is originated from the mindset that blood is thicker than water, and this thick blood should be none other than Dangun blood. It’s time for ‘Korean wave(halliu)’ movie maker to take into consideration what kind of themes they have to adopt and how they make scenes for open society that is broad-minded to the extent of embracing people from different ethic groups. (Inje Uuniversity)