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박인영,Myongsun Son,안은선,Young-Woong Kim,공영윤,윤영대 한국분자세포생물학회 2020 Molecules and cells Vol.43 No.11
Lck-interacting transmembrane adaptor 1 (LIME) has been previously identified as a raft-associated transmembrane protein expressed predominantly in T and B lymphocytes. Although LIME is shown to transduce the immunoreceptor signaling and immunological synapse formation via its tyrosine phosphorylation by Lck, a Src-family kinase, the in vivo function of LIME has remained elusive in the previous studies. Here we report that LIME is preferentially expressed in effector T cells and mediates chemokine-mediated T cell migration. Interestingly, in LIME-/- mice, while T cell receptor stimulation-dependent proliferation, differentiation to effector T cells, cytotoxic T lymphocyte (CTL) function and regulatory T lymphocyte (Treg) function were normal, only T cell-mediated inflammatory response was significantly defective. The reduced inflammation was accompanied by the impaired infiltration of leukocytes and T cells to the inflammatory sites of LIME-/- mice. More specifically, the absence of LIME in effector T cells resulted in the reduced migration and defective morphological polarization in response to inflammatory chemokines such as CCL5 and CXCL10. Consistently, LIME-/- effector T cells were found to be defective in chemokine-mediated activation of Rac1 and Rap1, and dysregulated phosphorylation of Pyk2 and Cas. Taken together, the present findings show that LIME is a critical regulator of inflammatory chemokine-mediated signaling and the subsequent migration of effector T cells to inflammatory sites.
줌바(Zumba) 프로그램 참여가 초등학생의 건강 관련 체력에 미치는 영향
박인영,조욱상 한국사회체육학회 2018 한국사회체육학회지 Vol.0 No.74
The purpose of this study is to analyze the impact of Zumba nfietss program as physical education on the health of elementary school students and to provide data neede dto develop exercise programs at school . To do this, the exercise group and the control group were chosne among fourth graders. These two group s were of 47 students who did not make any significant differencse in their health (cardiovascular endurance , muscle strength, muscle endurance and flexibility). For 8 weeks, only the exercise group was provided with the Zumba Fitness physical education class, and the control group underwent common physical education class in accordance with the curriculum. The data obtained by measuring the health related fitness of each group before and after class were analyzed using SPSS 25.0 staisttical program. The difference between the groups after the experiment was verified as independent t- tes tand the change over time in the group wa s verified as ANCOVA and paired t-test. The results of the analyiss are as follows. First, the group participatin g in the Zumba Fitness physical education class had statistically significant improvement in their muscle strength, muscle endurance, and flexibility factors after the experimen t.Second, comparing the health related fitness o f the experimental group with the control group, in the experimetnal group had greater cardiovascular endu-r ance, muscle strength, muscle endurance and flexibility than the controlled group.