인삼이 사혈성빈혈 회복 및 Erythrokinetics에 미치는 영향

박용덕,이인숙,김명선,Park, Yong-Duck,Lee, In-Sook,Kim, Myung-Sun 대한생리학회 1981 대한생리학회지 Vol.15 No.1

For centuries, ginseng has been used for the therapeutic purpose in oriental herb medicine. Several studies have been conducted in the past to evaluate the effect of ginseng on erythropoiesis. However the results were controversial. We therefore attempted in the present studies to evaluate the effect of ginseng on the erythropoietic activity. In one series of experiments, the recovery pattern of peripheral blood(red cell count, hemoglobin content, hematocrit and reticulocyte count) was studied in posthemorrhagic anemic rabbits. After animals were maintained with normal(control group) or 1 gm% ginseng (experimental group) diet for 2 weeks, hemorrhagic anemia was induced by withdrawing blood equivalent to 25% of the total blood volume and then changes in peripheral blood were followed for following 30 days. In other series of experiments, we studied effect of ginseng on erythrokinetics using $^{59}Fe$. $^{59}Fe(10{\sim}40\;{\mu}Ci/animal)$ was injected intravenously after animals were fed with normal (control group) or 1 gm% ginseng(experimental group) diet for 2 weeks. And radioactivities in the blood compartments were measured at appropriate intervals for 15 days. Front these various erythrokinetic parameters were estimated. Results are summarized as follows: 1) Reticulocyte count was higher in the experimental group than in the control group after 2 weeks of administration of experimental diet. During the posthemorrhagic period, the reticulocyte count increased in both the control and experimental groups, but the increase appeared much earlier in the experimental group. 2) The posthemorrhagic recoveries of hematocrit, hemoglobin content and red cell count appeared to be faster in the experimental group as compaired with the control group. 3) The half life$(T_{1/2})$ of $^{59}Fe$ in the plasma was significantly(P<0.05) shorter in the experimental group(82.6 min, N=8) than in the control group(121 min, N=6). Plasma iron turnover (PIT) of the experimental group (1.78 mg/dl/24 hr.) was approximately 4 times greater than that of the control group(0.45 mg/dl/24 hr.). 4) The maximum red cell utilization(RC-U) was 82.1% in the experimental group ana 74.5% in the control group. Red cell iron turnover(RIT) of the experimental group(1.62 mg/dl/24 hr.) was slightly higher than that of the control group(0.35 mg/dl/24 hr). 5) Erythron turnover was significantly(p<0.05) greater in the experimental group(1.27 mg/dl/24 hr.) than in the control group(0.24 mg/dl/24 hr.). Marrow transit time of the experimental group(2.05 days) tended to he faster than that of the control group(2.84 days). These results suggest that the gingseng improves the recovery of posthemorrhagic anemia and stimulates the erythropoiesis in rabbits.

Effect of Cadmium on Renal Organic Anion Transport In vitro

박용덕,최장규,박양생,Park, Yong-Duck,Choi, Jang-Kyu,Park, Yang-Saeng The Korean Physiological Society 1988 대한생리학회지 Vol.22 No.1

가토 신피질 절편에서 p-aminohippurate (PAH) 이동에 대한 카드뮴 이온(Cd)의 영향을 조사하여 다음과 같은 결과를 얻었다. 조직절편과 용액내의 PAH 농도비(S/M PAH)는 용액내에 Cd이 0.1 mM이상 존재할 때에 현저히 감소되었다. PAH influx에 대한 동력학적 분석결과 Cd에 의하여 influx의 최대이동율(즉 $V_{max}$)은 심하게 감소되지만 운반체와 기질간의 친화력(즉 $K_{m}$)에는 변화가 없었으며, 수동적 influx 역시 변화되지 않았다. 신피질조직의 산소 소모율은 1 mM Cd에 의하여 35% 가량 억제되었으며, 신피질 microsome 분획의 Na-K-ATPase 활성도는 Cd 농도가 $10^{-7}M$ 이상일 때 의의있게 억제되었다. 이상의 결과로 미루어 볼 때 신장조직이 카드뮴이온에 직접 노출될 경우 유기음이온의 능동적 이동능이 심하게 저해된다고 사료된다.

한국인 치과의사의 비스포스포네이트 관련 악골괴사에 대한 인식 연구

박용덕(Yong-Duck Park),김영란(Young-Ran Kim),김덕윤(Deog-Yoon Kim),정윤석(Yoon-Sok Chung),이정근(Jeung-Keun Lee),김여갑(Yeo-Gab Kim),권용대(Yong-Dae Kwon) 대한구강악안면외과학회 2009 대한구강악안면외과학회지 Vol.35 No.3

Recently, an increasing number of bisphosphonate related osteonecrosis of the jaw(BRONJ) is being reported. A guideline has been already established in the US, but it does not seem to be fully recognized by clinicians in Korea. Therefore, a survey study was done to inform and have clinicians realize the seriousness of BRONJ. 1,341 practitioners were randomly selected out of 13,405 practitioners(by Feb of 2008, KDA) in Korea. A questionnaire was given to them between May to July in 2008. Questions were designed to investigate each respondent’s experience term years in the clinic, occupation, speciality, awareness on risk of bisphosphonate, experience on treating osteonecrosis patients, awareness about the guideline on BRONJ suggested by AAOMS and whether if they ask about bisphosphonate medication history to patients before invasive treatment. 45.1% of the clinicians have reported on experiencing delayed healing on bone exposed site after extraction both in the maxilla and the mandible. However, clinicians have asked the patients whether if they are on bisphosphonate or not in only 15.1% of these cases. 56.5% of the clinicians simply knew about BRONJ but only 28.9% of the clinicians were aware that bisphosphonate can cause osteonecrosis after invasive dental treatment. Only 19.3% knew about the contents of guideline on BRONJ and 57.2% were aware of the seriousness of BRONJ. Clinicians with shorter clinical experience term were more aware of BRONJ and the guideline on BRONJ than the experienced clinicians. But awareness of the possibility of BRONJ after invasive dental treatment were about the same regardless of their clinical experience. The results show that Korean clinicians need to be more aware about BRONJ. Data on BRONJ cases in Korea should be collected and provided with additional education to let Korean clinicians know and be more aware about BRONJ.

증례보고 : 갑상선 전적출술 후 회복실에서 발견된 양측 성대마비

박용덕 ( Yong Duck Park ),김민석 ( Min Suk Kim ),최락민 ( Rak Min Choi ),노재훈 ( Jae Hoon Noh ) 대한마취과학회 2009 Korean Journal of Anesthesiology Vol.57 No.4

A patient had respiratory difficulty and hoarseness following total thyroidectomy due to bilateral vocal cord palsy. The patient was a 60-year-old man who underwent total thyroidectomy for papillary carcinoma of the thyroid. He had no laryngeal symptoms prior to the operation. Anesthesia lasted 3.5 hours and was uneventful. Spontaneous respiration resumed after reversal of the neuromuscular blockade. After arriving at the post-anesthesia care unit, he complained of respiratory difficulty and hoarseness. We confirmed bilateral vocal cord palsy by fiberoptic laryngoscopy. It is necessary to perform a complete and thorough search for the underlying cause of vocal cord palsy. (Korean J Anesthesiol 2009;57:540∼3)

슬관절 전치환술을 받는 환자에서 진정 동안 발생한 기도 폐쇄가 수축기 혈압과 중심정맥압에 미치는 영향

박관식 ( Kwan Sik Park ),김대희 ( Dae Hee Kim ),문봉기 ( Bong Ki Moon ),박용덕 ( Yong Duck Park ),채윤정 ( Yun Jeong Chae ) 대한마취과학회 2009 Korean Journal of Anesthesiology Vol.57 No.1

Background: Severe respiratory variations of systolic arterial and central venous pressure (CVP) may increase the risk of embolic event in orthopedic patient. As airway obstruction during sedation can cause this respiratory variation, we evaluated the degree of variations of systolic blood (SBP) and CVP during airway obstruction period. Methods: Fifteen females who had obstructed airway during total knee replacement (TKR) were included for the study. After regional anesthesia were established, SBP and CVP variations were analyzed according to the three periods; baseline, obstruction, and airway, respectively. Calculated CVP variables were similar to SBP variables as below: ΔSBP=Exp(max) (maximal value at expiration)-Insp(nadir) (minimal value at inspiration), %ΔSBP=(ΔSBP/Exp(max))×100. The frequencies of pulsus paradoxus (PP) and negative inspiratory CVP (NIC) were also measured. Results: At obstruction period, ΔSBP was 21.7 mmHg and 93.3% of patient had PP. Also, ΔCVP was 19.3 mmHg and 100% of patient showed NIC. %ΔCVP (140%) was larger than %ΔSBP (16%). And ΔCVP was inversely correlated with baseline and obstruction SBP and %ΔCVP was also inversely correlated with baseline CVP at obstruction period. Conclusions: During airway obstruction in sedated TKR patients, variations of CVP are larger than those of SBP. So we have to monitor CVP continuously as well as SBP so as not to increase the possible risk of respiratory of variation. (Korean J Anesthesiol 2009; 57: 38~43)

개원치과의사를 대상으로 한 의료광고 허용기준에 관한 연구

권호근(Ho-Keun Kwon),정기호(Ki-Ho Jung),최충호(Choong-Ho Choi),박용덕(Yong-Duck Park) 대한치과의사협회 2003 대한치과의사협회지 Vol.41 No.5