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제주도 주목(Taxus cuspidata S. et Z.)의 Taxol 및 Cephalomannine의 함량분석
곽상수(Sang Soo Kwak),최명석(Myung Suk Choi),박용구(Kyung Soo Ko),고경수(Young goo Park),유장렬(Jang Ryol Liu) 한국생약학회 1995 생약학회지 Vol.26 No.2
To seek for a stable supply source of taxol as an anticancer agent urgently needed for the treatment of ovarian cancer, the concentrations of taxol and cephalo mannine in bark and needles of 37 yew (Taxus cuspidata S. et Z.) trees grown in 6 locations of Cheju Island were analyzed by using HPLC. A considerable variation in the content was observed in plant part and the location. The average taxol content in the needles (220.3 ± 56 ㎍ per g dry wt) was ca. 4 times hgher than that in the bark, whereas the content of cephalomannine in the needles (353 ± 141 ㎍) was ca. 5 times higher than that in the bark. Particularly, even within Cheju Island, needles from trees grown near the coast including Sogwipo area contained much higher taxol contents than needles from trees grown at mountain locations, indicating that taxane level is affected by environmental effects. Taxol in the needles was confirmed by electrospray mass spectrometry. These results suggest that the needles of yew trees growing in Cheju Island may provide a renewable source for taxol.