http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
박수경 동국대학교 경주대학 2000 東國論集 Vol.19 No.-
Owing to the appearing in succession of new information among genetic biomarkers of bladder cancer studied, new information are very important value in the diagnosis of patients, the screening of general population, and the prediction of biological behavior and prognosis. Despite of rapid development there are a few review about this markers in bladder cancer from which gross summary of results as well as their optimal function can be considered. This study was performed to review the literature in genetic biomarkers of bladder cancer so as to assess the usefulness. Necessary information were collected in Journal published on 'medline' and Korean Journal of Urology from Jan 1, 1980. The chromosomal abnormalities were evaluated to be available or early diagnosis, the prediction which a early treatment are performed before the recurrence of breast cancer, the prediction of cancer progression and prognosis. DNA analysis were evaluated to be available on the differential diagnosis between benign and malignant bladder tumor, the prediction of patients who have a high probability of the progression to malignant bladder tumor, the prediction of intermediate risk group, the sentinel of disease progression, the prediction of treatment effect and to be possible to the screening. P53 gene which control a cancer cell growth and cancer invasion or metastasis, are related to the prognosis of bladder cancer. Other oncogenes and suppressor genes are obscure in their role up to the present time. In view of screening of general population and diagnosis of bladder cancer, the genetic biomarkers have a low availability because the specificity which relate to differentiate bladder cancer from other cancer is a low. The analysis of genetic biomarkers could be considered in the workers with a high exposure of carcinogen when the problem of high cost be solve.
충주시 고등학생의 최근 4년간(1988-2001) B형간염 표면항원 및 항체 양성률 조사
김형수,이건세,장성훈,박수경,김청식,이창희,권혁중,정순섭 한국역학회 2002 Epidemiology and Health Vol.24 No.2
Objective : Since Korea has been known to be of the endemic area for hepatitis B virus(HBV) infection, vaccination for HBV has been recommended for all neonates in Korea. After starting vaccination in 1983, the change of sero-positivity of HBsAg and HBsAb is expected. This study was carried out to investigate the seropositive rate of hepatitis B virus surface antigen and antibody in high school freshmen students in Chungju-city. Methods and Materials : From 1998 to 2001, a total of 11,735 who were born in 1982 to 1986, were enrolled in this study. HBsAg and anti-HBs were tested by reversed passive hemagglutination and passive hemagglutination, respectively. Results : The study population was 11,735 students who were composed of 5,813 males (49.6%) and 5,914 females (50.4%). The HBsAg sero-positivity of male and female students was 3.25% (n=381) and 2.59% (n=153) respectively. The anti-HBs sero-positivity of male and female students was 62.2% (n=3,154) and 64.1% (n=2,969) respectively. There are significant difference observed in comparison of HBsAg and anti-HBs seropositivity according to sex (p<0.05). From 1982 to 1986 on birth year, anti-HBs sero-positivity has been increased significantly from 63.3% to 73.3%. But the change of HBsAg sero-positivity has not been changed significantly. Conclusions : As compared with previous studies of HBsAg and anti-HBs, the sero-positive rate of HBsAg has not been changed but that of HBsAb has been increased significantly. This result revealed that the effect of HBV vaccination program was successful.