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새로운 내부 방사선 치료용 166Ho - Chitosan 착물 및 그 응집입자의 제조에 관한 연구
박경배(K . B . Park),김영미(Y . M . Kim),신병철(B . C . Shin),김재록(J . R . Kim) 대한핵의학회 1996 핵의학 분자영상 Vol.30 No.3
N/A Chitosan is a polysaccharide of natural orgin obtained by full or partial deacetylation of chitin, a very abudant natural polymer, which has the properties of biocompatibilities, bioaffinities, and biodegradabilities. The free amino group of chitosan should be participated in forming chelate with holmium (β-emitter). Ho-166(NO3)3. 5H2O of high radionuclidic purity of upto 99.9% was made by neutron irradiation of naturally occuring Ho-165(NO3)3., 5H2O, and then reacted with the prepared chitosan solution. The effect of pH, reaction time, the concentration and viscosity of chitosan and the amount of Ho-166 on forming Ho-166-chitosan complex (Ho-166-CHICO) were investigated. Ho-166-chitosan macroaggregate(Ho-166-CHIMA) was made from Ho-166-CHICO. Their physical properties such as radionuclidic purity, particle size distribution, stability in vitro and vivo were examined. Their high in vitro and vive stability makes them attractive agents for interna1 radiotherapy by local administeration.