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SKH-1 마우스 모델을 이용한 로즈마리와 시트러스 혼합추출물의 피부 광보호 효과
함영주 ( Young Joo Ham ),빈센트오르테가 ( Vicente V. Ortega ),프란시스코호세코메즈 ( Francisco Jose Gomez ),옵둘리오베나벤트가르카 ( Obdulio Benavente Garcia ),줄리안카스티요산체스 ( Julian Castillo Sanchez ),민은설 ( Eun Seol Min ) 대한미용학회(구 대한미용과학회) 2015 대한미용학회지 Vol.11 No.4
The continuous exposure of ultraviolet (UV) rays associated with sunlight has been known to have harmful effects on the human body including hyperpigmentation, photoaging, and skin cancer. There are many different ways to protect skin against harmful effects of UV radiation. A combination of rosemary and citrus bioflavonoids extracts was reported to inhibit the harmful effects of UV irradiation on human HaCaT keratinocytes and also it inhibited the harmful effect on the human volunteers following oral administration. Here, in vivo experiments were carried out to determine the capacity of orally administered rosemary and citrus bioflavonoids extracts to inhibit skin photocarcinogenesis in SKH-1 mice. For this study, animals were placed into two groups: UV irradiation (control group) and UV irradiation+drinking water containing rosemary extract and citrus extract (ratio 1 : 1) at a dose of 1 mg/day (treatment group). For UV irradiation, animals were placed in PVC cages with individual separator for each mouse and with a metallic lattice cover; the each cage was then placed under the UV light lamp at a light-bulb/skin distance of 20 cm. Irradiation events were conducted for 70 minutes per session, three times per week, until the end of the experiments (80 sessions). Four out of ten animals in the treatment group were developed into the lesions on the skin, and the final size of the lesions was comparably smaller than those developed in the control group. The lesions were keratinous nodules without ulceration, telangiectasias,induration or infiltration. The rosemary and citrus bioflavonoids extracts showed that it may decrease the incidence of skin photocarcinogenesis, and may be considered as a dietary supplement for the alleviation or prevention of skin photocarcinogenesis.