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다발성 골수종 환자에서 Lenalidomide와 Thalidomide에 의한 말초신경병증 발병 비교 연구
이소희(So Hee Lee),우지윤(Ji Yun Woo),황보신이(Shin Yi Hwangbo),민미나(Mi Na Min),한옥연(Ok Youn Han) 대한약학회 2020 약학회지 Vol.64 No.6
Lenalidomide (LD) inhibits angiogenesis and exerts immunosuppressive effects. It has been used to treatmultiple myeloma and is known to show positive differences in side effects compared to thalidomide (TD). Peripheralneuropathy, one of the most common complications of TD, has been reported to be less frequent with LD treatment. However, no local study has been conducted to compare the incidence of peripheral neuropathy associated with TD andLD administration. Therefore, this study was performed to investigate the appearance, aggravation, or improvement ofperipheral neuropathy and the relevant risk factors in patients treated with LD and TD. The electronic medical records of169 patients with multiple myeloma who had been treated with LD and TD in a tertiary hospital between March 2014and March 2015 were retrospectively reviewed. There were 85 patients in the LD group and 84 patients in the TD groupfor the final analysis. An increase in severity of peripheral neuropathy after treatment was observed in 2.4% and 19.1%of patients in the LD and TD groups, respectively (p<0.001). Six patients in the TD group showed two or more increasesin grade. In total, 48.2% in the LD group and 10.7% in the TD group (p<0.001) continued chemotherapy without anyaggravation of peripheral neuropathy. The patients treated with LD showed less increase in severity of peripheralneuropathy compared with those treated with TD. A significant difference was observed between the groups in thepercentage of patients who continued treatment without peripheral neuropathy aggravation.
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의료기관의 Internet을 이용한 질의응답 업무 실태조사 : 약제과의 역할에 대한 고찰 Consideration of the role of pharmacy
한윤덕,최선,민미나,한옥연,황보신이 한국병원약사회 2002 병원약사회지 Vol.19 No.2
As information retrieval through internet has been popularized, a demand of medical information has been increased. But most medical information is provided by commercial web sites without evaluation the quality of information. So we suggested there were a demand for drug information supplement by special medical institutions. The aim of this research was to investigate medical information on the web sites of hospital, especially department of pharmacy, ad discuss methods of improvement. We selected the web sites of tertiary medical institutions had over 500 beds and evaluated question and answer (Q&A) sites on the webs in terms of consulting fields, overall organization and easiness of access. Among the consulting fields, we selected medicine Q&A field and estimated answering method, quality of Q&A and the time required to answer. We also conducted a verbal questionnaire survey of patients or their family to check the demands of medical information. Among the 39 institutions, 23 institutions(59%) performed Q&A on the webs and the consulting fields were mainly composed of disease(95.7%, 22 of 23) and medicine(26.1%, 6 of 23). Overall organization of Q&A sites was managed by central or each clinical department. Both management methods had similar rates(54.5%, 41%) but all Q&A sites of medicine was conducted by department of pharmacy. The access to the Q&A sites was easy regardless of consulting fields. We couldn't evaluate Q&A sites of medicine precisely because the only three web sites had conducted Q&A during the research period. As a result of questionnaire survey, 83.3% of answerers who were using internet expressed positive opinions about health information obtaining through the Q&A site of medical institution. But most people didn't know how to use the Q&A sites of hospital. In conclusion, disease consultation on the web was relatively activated but medicine consultation was very insufficient. So we should make an effort to provide medicine information on the web and discuss pharmacist's role in this part.
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