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민관기,표석능,이동권 성균관대학교 약학연구소 1999 成均藥硏論文集 Vol.11 No.-
Abstract-Streptococcus pneumoniae (pneumococcus) is the most frequent causative agent of acute bacterial pneumonia. Outstanding characteristic of pneumococcus is an ample polysaccharide capsule that is highly antigenic agent and is the major factor for classification of pneumococcus into more than 94 serotypes. In this study, production of capsular polysaccharide from Streptococcus pneumoniae type 23 was optimized by supplementation of metal ions or by modulation of culture conditions. When brain heart infusion (BHI) broth was supplemented with 1 mM concentration of CaCl_2, CuSO_4 and MgSO_4, growth of pneumococcus as well as polysaccharide yield were stimulated. Also slight aeration gave rise to better polysaccharide yield.
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신규 Carbapenem 유도체 CRB 529, 535, 538, 545, 550의 시험관내 항균력 평가
민관기(Kwan Kee Min),김준겸(Joon Kyum Kim),이홍우(Hong Woo Lee),김정우(Jeong Woo Kim) 대한약학회 1995 약학회지 Vol.39 No.3
The in vitro antibacterial activities of new carbapenem, CRB 529, 535, 538. 545 and 550 with meropenem and imipenem were compared. CRB 529, 535, 538, 545 and 550 proved to have a broad antibacterial spectrum. Its in vitro activity against standard 20 strains was almost the same as that of imipenem and slightly higher than that of meropenem. However, against clinical isolated P. aeruginosa, CRB 529. 535, 538, 545 and 550 showed significantly higher activity than imipenem, and also CRB 529, 535, 538, 545 and 550 showed almost the same activity than imipenem and meropenem against 82 clinical isolated strains including S. aureus (MRSA), S. aureus (MSSA), E. faecalis, E. facium, E. coli, P. aeruginosa, K. pneumonia, P. mirabiris, P. stuartii, M. morganii, C. freundii, E. cloacae, S. marcescens and A. calcoaceticus var. anitratus. The stability of CRB 529, 535, 538, 545 and 550 against porcine renal dehydropeptidase-I (DHP-I) was 10 folds higher than that of imipenem and was 3 folds higher than that of meropenem.
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민관기(Kwankye Min),전익수(Iksu Jun) 한국농업경제학회 2021 農業經濟硏究 Vol.62 No.2
The purpose of this paper is to compare and analyze the determinants of agricultural income by quantile through quantile regression considering the heterogeneous distribution of agricultural income of returning farmers. Unlike OLS of the mean concept, quantile regression is an analysis method that can consider the entire distribution, including each quantile. In this study, the 25th, 50th, and 75th quartiles were analyzed and compared to each other and they were compared with the OLS result. The results showed that 15 factors in the OLS result, 4 factors in the 25th quartile, 9 factors in the 50th quartile, and 14 factors in the 75th quartile were found to have a statistically significant effect. This can leads to a conclusion that the OLS result, which is based on the average concept, was relatively more influenced by high quantiles such as the 75th quartile. In other words, this implies that the characteristics of low-income return farmers were relatively less reflected. The magnitude of the influence also showed a similar tendency to increase with higher quantiles.
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민관기(Kwan Kee Min),표석능(Suhk Neung Pyo),이동권(Dong Kwon Rhee) 한국응용약물학회 1999 Biomolecules & Therapeutics(구 응용약물학회지) Vol.7 No.3
Streptococcus pneumoniae (pneumococcus) is the most frequent causative agent of acute bacterial pneumonia. Outstanding characteristic of pneumococcus is an ample polysaccharide capsule that is highly antigenic agent and is the major factor for classification of pneumococcus into more than 94 serotypes. In this study, production of capsular polysaccharide from Streptococcus pneumoniae type 23 was optimized by supplementation of metal ions or by modulation of culture conditions. When brain heart infusion (BHI) broth was supplemented with 1 mM concentration of CaCl₂, CuS0₄ and MgS0₄, growth of pneumococcus as well as polysaccharide yield were stimulated. Also slight aeration gave rise to better polysaccharide yield.
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신규 Carbapenem 유도체 CRB 529 및 CRB 550의 생체내 항균효과와 약물동태의 비교
김준겸(Joon Kyum Kim),민관기(Kwan Kee Min),이주몽(Ju Mong Lee),이홍우(Hong Woo Lee),김정우(Jung Woo Kim) 대한약학회 1995 약학회지 Vol.39 No.4
1-beta-Methyl carbapenem-2-substituted pyrrolidine derivatives, CRB 529 and CRB 550, were synthesized as investigational carbapenem derivatives. It has been reported that the in vitro antibacterial activities of the compounds against G(+) and G(-) bacteria were almost the same or more effective than those of imipenem (IPM) and meropenem (MEPM), and also showed better in vivo efficacy than MEPM and imipenem/cilastatin (IPM/CS) against representative G(-) organisms, P. aeruginosa and MRSA organisms, S. aureus. The antibacterial activities, pharmacokinetics and protective efficacy of IPM/CS and CRB 529 and CRB 550 were conducted after subcutaneous or intravenous administration to mice and rats. The pharmacokinetic parameters of CRB 529 and CRB 550 in mice were as follows; the observed maximal serum concentrations (CMAX) following I.V. administration were 87.5 and 101mcg/ml for CRB 529 and CRB 550, respectively, and 63.6mcg/ml for IPM/CS. The half-lives (t1/2) were 14.0 and 12.0 min for CRB 529 and CRB 550, respectively, and 14.8 min for IPM/CS. In rats, CMAX after I.V. administration were 74.0 and 91.8mcg/ml for CRB 529 and CRB 550, respectively, and 41.2mcg/ml for IPM/CS. The tissue levels of CRB 529 and CRB 550 and IPM/CS after I.V. administration at a dose of 20mg/kg decreased by the following order; lung, heart, kidney, liver and spleen for CRB 529, kidney, liver, lung, heart and spleen for CRB 550 and kidney, lung, liver, heart, spleen and brain for IPM/CS. In systemic infection, CRB 529 and CRB 550 showed excellent efficacies against P. aeruginosa and S. aureus (MRSA) at a dose of 5mg/kg. The PD50s were 0.80, 0.36mg/kg for CRB 529 and CRB 550, respectively, and 3.22mg/kg for IPM/CS against P. aeruginosa. The corresponding values against S. aureus (MRSA) were 76.0, 55.3mg/kg for CRB 529 and CRB 550, respectively, and 146mg/kg for IPM/CS. In local infection, the antibacterial activities of CRB 529 and CRB 550 were more effective than those of IPM/CS against intrarenal infection with E. coli and P. aeruginosa and also showed as effective as IPM/CS against respiratory tract infection with E. coli and P. aeruginosa at a dose of 5mg/kg.
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