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김대근(Dae Keun Kim),최상운(Sang Un Choi),류시용(Si Yong Ryu),이강노(Kang Ro Lee),지옥표(Ok Pyo Zee) 대한약학회 1998 약학회지 Vol.42 No.3
Activity-guided fractionation and repeated column chromatography afforded two cytotoxic compounds R-3 and R-4 from the root of Rumex japonicus HOUTT. Compounds were identified as musizin and emodin, respectively, by the physicochemical and spectral data. Besides R-3 and R-4, two compounds R-1 and R-2, chrysophanol and physcion, respectively, were also isolated. The compound R-3 and R-4 exhibited cytotoxicity against cultured human tumor cell lines, A-549, SK-OV-3, SK-MEL-2, XF498 and HCT15 with ED50 values ranging from 2.68 to 10.06mcg/ml.
김대근,최상운,류시용,이강노,지옥표 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1
Activity-guided fractionation and repeated column chromatography afforded two cytotoxic compounds R-3 and R-4 from the root of Rumex japonicus HOUTT. Compounds were identified as musizin and emodin, respectively, by the physicochemical and spectral data. Besides R-3 and R-4, two compounds R-1 and R-2, chrysophanol and physcion, respectively, were also isolated. The compound R-3 and R-4 exhibited cytotoxicity against cultured human tumor cell lines. A-549, SK-OV-3, SK-MEL-2, XF498 and HCT15 with ED_50 values ranging from 2.68 to 10.06㎍/㎖.