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류승준 ( Seung Jun Ryu ),이충식 ( Chung Sik Lee ),박보라 ( Bo Ra Park ),서종훈 ( Jong Hoon Seo ),강형원 ( Hyung Won Kang ),류영수 ( Yeong Su Lyu ),김태헌 ( Tae Heon Kim ) 대한한방신경정신과학회 2007 동의신경정신과학회지 Vol.18 No.1
Objective : The aim of this study was to investigate effects of Gagambosim-Tang(GBT) of focal brain ischemic injury induced by intraluminal filament insertion in the rats.Method : The ischemia was induced by intraluminal filament insertion into middle cerebral artery. Eight-arm radial maze was designed for the behavioral task. Gagambosim-Tang was orally administrated in SD rats for 21 days. The task was started on the 4th week after focal brain injury, and performed two trials per day for 6days. The effects of Gagambosim-Tang on neuroprotective agents in cresyl violet, choline acetyltranferase(ChAT), nerve growth factor (NGF)-stain and c-Fos with ischemic injury were investigated.Results : The errors in the eight-arm radial maze task were significantly decreased in normal group compared with control group on 2-6days, GBT 1X(42.2 mg/ml)orally administrated group on 1days, GBT 6X(253.2 mg/ml) on 3, 5, 6days. The rate of correct choice was increased in normal and GBT 6X groups. The neuroprotective effect in the hippocampal CA1 was increased in normal and GBT 1X, GBT 6X groups compared with control group. The density of ChAT in the hippocampal CA1 was increased in normal and GBT6X groups compared with control group. The density of NGF in the hippocampal CA1 was increased normal and GBT6X groups compared with control group. The number of c-Fos-positive neurons in the hippocampal CA1 was increased in normal and GBT 6X groups compared with control group.Conclusion : These results suggest that Gagambosim-Tang may have protective effect on dementia.