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박종희,도원임,Park, Jong-Hee,Do, Won-Im 한국생약학회 2007 생약학회지 Vol.38 No.1
Chinese crude drug "Lu-ti-cao"(鹿蹄草) has been used as a remedy for beriberi, cut bleeding, snake bite, etc. In Korea, the drug is called "Nok Je Cho" and has been used as a folk medicine of the same effect as that of Chinese equivalent. The original plant of this drug has not yet been as certained. To clarify the botanical origin of "Nok Je Cho", the morphological and anatomical characteristics of the leaves of Pyrola species growing in Korea, i.e. P. incarnata, P. japonica, P. minor, P. renifolia, P. secunda were studied. As a result, it was clarified that "Nok Je Cho" was the leaf of Pyrola japonica and Pyrola minor.
서정원 ( Jeong-won Seo ),이재옥 ( Jaeok Lee ),채규한 ( Gyuhan Chae ),도원임 ( Won-im Do ),이상훈 ( Sang-hun Lee ),정래석 ( Raeseok Jung ),신원 ( Won Shin ) 한국보건정보통계학회(구 한국보건통계학회) 2017 보건정보통계학회지 Vol.42 No.3
The aim of this study is to provide a method to apply the electronic data standard for electronic transmission of individual case safety reports (ICSRs) in Korea. In Korea, it is necessary to implement the ICH E2B guideline and the ICH MedDRA guideline within 5 years after approval to join ICH members in November 2016. With the spread of the internet network and the IT infrastructure worldwide, Data standardization has been developed not only by major countries such as the US, Europe, and Japan, but also by around the world. In addition, it is necessary to strengthen voluntary or mandatory reporting from consumers, pharmaceutical companies, and healthcare professionals by following the standardized electronic information exchange system for international sharing. This can be an opportunity to overcome limitations on the quality and quantity of information available at the time of authorization. Based on the data system applying the electronic standards, it is possible to search and prevent Korean inherent side effects by using the collected and analyzed information. The exchange of information of standardized data will enable regulatory authorities to communicate with data from different structure as well as many other countries with a single common document. We first reviewed the necessity of development of data standard for drug safety reporting. The ICH E2B guideline adopted as an international standard has been analyzed and the need for introduction into Korea has been examined. In major ICH regions like US, EU and Japan, regional implementation guides for E2B (R3) guideline were prepared and implemented in accordance with the guide. The guides and the status of these countries were compared and analyzed. Regional implementation guide for introducing ICH E2B, an international standard, in Korea was made which was reflecting domestic regulations such as pharmaceutical safety management regulations.
뇌 신호원의 시계열 추출 및 인과성 분석에 있어서 ICA 기반 접근법과 MUSIC 기반 접근법의 성능 비교 및 문제점 진단
정영진,김도원,이진영,임창환,Jung, Young-Jin,Kim, Do-Won,Lee, Jin-Young,Im, Chang-Hwan 대한의용생체공학회 2008 의공학회지 Vol.29 No.4
Recently, causality analysis of source time series extracted from EEG or MEG signals is becoming of great importance in human brain mapping studies and noninvasive diagnosis of various brain diseases. Two approaches have been widely used for the analyses: one is independent component analysis (ICA), and the other is multiple signal classification (MUSIC). To the best of our knowledge, however, any comparison studies to reveal the difference of the two approaches have not been reported. In the present study, we compared the performance of the two different techniques, ICA and MUSIC, especially focusing on how accurately they can estimate and separate various brain electrical signals such as linear, nonlinear, and chaotic signals without a priori knowledge. Results of the realistic simulation studies, adopting directed transfer function (DTF) and Granger causality (GC) as measures of the accurate extraction of source time series, demonstrated that the MUSIC-based approach is more reliable than the ICA-based approach.