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나경환(Kyounghwan Na),누엔 티 후옹(Thi Huong Nguyen),이상명(Sang-Myung Lee),양성욱,김진석(Jinseok Kim),윤의성(Eui-Sung Yoon) 대한기계학회 2009 대한기계학회 춘추학술대회 Vol.2009 No.11
The mechanical properties of a single-stranded deoxyribonucleic acid (ssDNA, 30-mer) in deionized water (DI) have been investigated by atomic force microscopy (AFM). Both ends of ssDNA molecules were labeled at 3’ and 5’ ends by biotin and thiol linkers, respectively. The streptavidin functionalized AFM tip ‘pick-up’ the biotinylated-end while the gold surface covalently bound to thiolated-end. The molecular stretching signal would be observed during the tip/sample separation process, and they were used to estimate the stiffness of the ssDNA molecule. We have obtained the different Young’s modulus results when the surface was un-modified or modified by a thiol backfilling spacer. Those were clarified by analyzing the binding force between DNA molecules and the un-modified gold surface or the thiol spacer-modified surface. The DNA binding to thiol spacer-modified surface is much weaker than that on the un-modified surface.