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노언주(Eon Joo Roh),김윤신(Yoon Shin Kim),김병관(Beung Gwan Kim) 한국유화학회 2008 한국응용과학기술학회지 Vol.26 No.2
In the previous study, we reported the antioxidative activity and inhibition of melanogenesis of Ligularia stenocephala extracts. In this study, inhibitory effect on elastase and production type I procollagen were investigated. The compounds which was investigated were 4-hydroxyacetophenone, vanillin, chlorogenic acid, caffeic acid isolated from Ligularia stenocephala. They were slightly mild on elastase inhibition activity but 4-hydroxyacetophenone, vanillin exhibited good inhibition activity on collagen production. These results suggest that Ligularia stenocephala may have potential as an anti-aging ingredient in cosmetics.
노언주(Eon Joo Roh),박시향(Si Hyang Park),황수미(Su Mi Hwang),노현수(Hyeon Su Ro),김병관(Byung Kwan Kim) 한국유화학회 2009 한국응용과학기술학회지 Vol.27 No.4
In this study, we evaluated the anti-oxidative, anti-wrinkle and whitening effect of Duchesnea indica (Andr.) Focke extract. Duchesnea indica (Andr.) Focke was extracted by two different solvents which were n-hexane and ethyl acetate. The anti-oxidant activity was measured by free radical scavenging activity using DPPH (1,1-diphenyl-2-picrylhydrazyl radical). And the inhibitory activities of tyrosinase for whitening effect and collagenase for anti-wrinkle were investigated. For anti-oxidant activity and whitening activity, ethyl acetate fraction of Duchesnea indica (Andr.) Focke extract showed more significant activity than n-hexane fraction of Duchesnea indica (Andr.) Focke extract. For anti-wrinkle activity, ethyl acetate fraction of Duchesnea indica (Andr.) Focke extract exhibited strong inhibition effects compared with reference. Therefore, Duchesnea indica (Andr.) Focke extract may be useful as a new antioxidant and anti-aging agent.
노언주 ( Eon Joo Roh ),박시향 ( Si Hyang Park ),황수미 ( Su Mi Hwang ),노현수 ( Hyeon Su Ro ),김병관 ( Byung Kwan Kim ) 한국유화학회 2010 한국응용과학기술학회지 Vol.27 No.4
In this study, we evaluated the anti-oxidative, anti-wrinkle and whitening effect of Duchesnea indica (Andr.) Focke extract. Duchesnea indica (Andr.) Focke was extracted by two different solvents which were n-hexane and ethyl acetate. The anti-oxidant activity was measured by free radical scavenging activity using DPPH (1,1-diphenyl-2-picrylhydrazyl radical). And the inhibitory activities of tyrosinase for whitening effect and collagenase for anti-wrinkle were investigated. For anti-oxidant activity and whitening activity, ethyl acetate fraction of Duchesnea indica (Andr.) Focke extract showed more significant activity than n-hexane fraction of Duchesnea indico (Andr,) Focke extract. For anti-wrinkle activity, ethyl acetate fraction of Duchesnea indico (Andr.) Focke extract exhibited strong inhibition effects compared with reference. Therefore, Duchesnea indico (Andr.) Focke extract may be useful as a new antioxidant and anti-aging agent.
노언주 ( Eon Joo Roh ),김병관 ( Byung Kwan Kim ),김덕술 ( Duck Sool Kim ) 한국유화학회 2011 한국응용과학기술학회지 Vol.28 No.2
In this study, we evaluated the anti-oxidative, whitening and anti-wrinkle effect of Tetrapanax papyriferum extract. Tetrapanax papyriferum was extracted by two different solvents which were n-Hexane, ethyl acetate. The anti-oxidant activity was measured by free radical scavenging activity using DPPH (1,1-diphenyl-2-picrylhydrazyl radical). And the inhibitory activities of tyrosinase for whitening effect and collagenase, elastase for anti-wrinkle were investigated. For anti-oxidant activity, ethyl acetate fraction of Tetrapanax papyriferum extract showed more significant activity than n-Hexane fraction of Tetrapanax papyriferum extract. For whitening activity, n-Hexane fraction of Tetrapanax papyriferum extract exhibited strong inhibition effects compared with reference. Therefore, Tetrapanax papyriferum extract may be useful as a new antioxidant and whitening agent.
김덕술 ( Duck Sool Kim ),노언주 ( Eon Joo Roh ) 한국유화학회 2011 한국응용과학기술학회지 Vol.28 No.2
Coumarin derivatives were shown to possess valuable pharmacological properties such as anticancer/anti carcinogenic, anti-inflammatory, anti helicobacter, anti genotoxic, neuroprotective and dietary effect. In this study, novel coumarin derivatives structurally related to 7-geranyloxycoumarin were effectively synthesised in good yields by Cs2CO3/acetonitrile in mild condition. The synthesis of geranyloxycoumarin derivatives in weak base(Na2CO3, K2CO3, Cs2CO3 etc)/CH3CN at room temperature obtained in good yield. On the other hand, the reaction of geranyloxycoumarin formation in strong base(NaOH, KOH, CsOH etc)/CH3CN at reflux condition obtained in low yield.