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Tumor-Homing Polymeric siRNA Nanocomplexes(PNCs) for Systemic Delivery in Cancer Therapy
남향수,구숙희,윤홍열,김광명,권익찬,김선화,이종범 한국공업화학회 2020 한국공업화학회 연구논문 초록집 Vol.2020 No.-
siRNA has been received a great attention as emerging gene therapeutics due to its superior capacity of specific gene silencing on post-transcription level. In our previous studies, rolling circle transcription technique can provide macro molecular weight siRNA as well as a structural formation of siRNA itself. Here, we developed the periodically repeated siRNA through RCT process band its delivery system using glycol chitosan derivatives. The synthesized polymeric siRNA Nanocomplexes(PNCs) has stable formation and protect the siRNA therapeutics against polyanion and nucleases attack formation in blood circulation. For tumor-targeted delivery of siRNA, the EPR effect could be adapted as a passive targeting strategy; immature blood vessel formation and lack of lymphatic drainage in tumor tissues might cause tumor-specific accumulation due to increased permeability and retention of PNC-VEGF in tumor interstitium.
Nucleic Acid Drugs Delivery via Rolling Circle Transcription for Cancer Therapy
남향수,이종범 한국공업화학회 2018 한국공업화학회 연구논문 초록집 Vol.2018 No.0
siRNA has been received a great attention as emerging gene therapeutics due to its superior capacity of specific gene silencing on post-transcription level. Despite its superb potential as gene therapeutics, the clinical application of siRNA is still limited. The long chain siRNA has been proposed as strategy to enhance its stability and to achieve efficient delivery. Here, We developed the periodically repeated siRNA through RCT process band its delivery system using glycol chitosan derivatives. The synthesized ENCs has stable formation and protect the siRNA therapeutics against polyanion and nucleases attack formation in blood circulation.
남향수,이종범 한국공업화학회 2017 한국공업화학회 연구논문 초록집 Vol.2017 No.1
siRNA has been received a great attention as emerging gene therapeutics due to its superior capacity of specific gene silencing on post-transcription level. However, the clinical application of siRNA is still limited due to its inherent properties and delivery problems. Herein, we developed the polymeric siRNA via rolling circle transcription process, and delivered the polymeric siRNA to tumor by using redox-sensitive glycol chitosan (GC) derivative as a gene carrier. The novel designed polymeric siRNA nanocomplex (PRC) showed the highly enhanced stability and less cytotoxicity, compared to conventional polyelectrolyte complexes. Because the PRC was designed to release active siRNA in cytoplasmic region, they showed high gene silencing efficacy with efficacy with efficient tumor targeting ability. According to the results, our PRC can be considered as a platform technology for efficient tumor targeted siRNA delivery.