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남다은,한희동,박윤정,김윤아,신병철 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.4
This study was to prepare the anionic liposomes which were to release anticancer drug (doxorubicin) at the hyperthermia temperature (~42℃) and to stabilize in bovine serum solution at 37℃. The vesicle size and zeta potential of liposomes in Tris-HC1 buffered solution (pH 7.4) were measured by an electrophoretic light scattering spectrophotometer. To estimate the stability of liposomes, liposome size was measured in bovine serum solution at 37℃ for 72h. The release of doxorubicin from liposome was determined by measuring the fluorescence intensity using fluorescence spectrophotometry with temperature and time. The size of liposomes was from 120 to 160 nm and zeta potential was from -33.3 ± 2.4 to -75.6 ± 6.9 mV. Anionic liposome was stabilized in bovine serum solution at 37℃ within 72h. Additionally, the release transition temperature of doxorubicin from liposomes was increased by increasing mole % of anionic phospholipid.