http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Candida albicans에 대한 각종 항진균제의 감수성 및 병용효과에 대한 연구
나해철,이승철,전인기,김영표 ( Hae Chull Nah,Seung Chul Lee,Inn Ki Chun,Young Pio Kim ) 대한피부과학회 1991 대한피부과학회지 Vol.29 No.4
N/A Studies on sensitivity and Synergism of Antifungal Agents against Candida albicans Hae Chull Nah, M.D., Seung Chul Lee, M.D., Inn Ki Chun, M.D., Young Pio Kim, M.D. Department of Dermatology, Chonnam University Medical School Kwangju, Korea At the present, various antifungal agents are available, but in clinical settings they are mostly applied as single agents. There are very few reports in the Iiterature on the effectiveness of the combined regimen. The autors tested the sensivities of 17 strains of Candida albicans to 8 popular antifungal agents. Fourteen strains were isolated in our clininc from the cases of mucocutaneous candidiasis and confirmed by API 20 Candida Kit and germ tube test. Three standard strains, Candida albicans 44858, Candida albicans 44859, and Candida albicans 28576 were also used. We also studied the efficacy of ketoconazole with 7 other antifungal agents. The results of minimum inhibitory concentration(MIC) studies were as follwed : ketoconazole, 4-128 mcg/㎖ ; itraconazole, 8-64 mcg/㎖ ; econazole, 16-64 mcg/㎖ ; miconazole, 8-32 mcg/㎖ ; clotrimazole, 8-64 ; 5-fluocytosine, 16-128 mcg/㎖ ; amphotericin B, 0.5-8 mcg/㎖ ; nystatin, 2-8 mcg/㎖. Synergistic effects with ketoconazole were observed in 100% of 5-fluocytosine, followed by clotrimazole(85.7%), econazole(64.3%), amphotericin B(58.8%), miconazole(21.4%), nystatin(14.3%), and itraconazole(6.7%), in order. Additive effects with ketoconazole were observed in 60% of itraconazole, followed by nystatin(50%), econazole(21.4%), miconazole(14.3%), clotrimazole(7.1%), amphotericin B(5.9%), and 5-fluocytosine(0%), in order. Antagonistic effects with ketoconazole were observed in 28.6% of nystatin, followed by itraconazole(26.7%), miconazole(14.3%), amphotericin B(11.8%), and econazole(7.1%), in order 5-flucocytosine and clotrimazole did not show antagonistic effects with ketoconazole. These results suggest that combination of synergistic agents may be of value in combating with Candida albicans infection and also in reducing the incidence of adverse reactions. Also, the fact that various synergistic effects can be obtained by combination of antifungal agents with different or similar mode of action suggests to us the necessity of accurate and standardized in vitro senstivity tests in the in the treament of candidiasis.