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식사시간에 따른 Ghrelin과 PYY3-36 농도 변화
최상한 ( Sang Han Choi ),이상엽 ( Sang Yeoup Lee ),김형회 ( Hyoung Hoi Kim ),전태용 ( Tae Yong Jeon ),김현준 ( Hyun Jun Kim ) 대한비만학회 2007 The Korean journal of obesity Vol.16 No.1
연구배경: 그렐린과 펩티드 YYJ3-36은 에너지 항상성과 연관된 위장관 호르몬이다. 저자 등은 식후 그렐린과 펩티드 YY3-36의 시간별 변화를 동시에 조사하였다. 방법: 연구를 시작하기 2주 전부터 아침식사시간을 엄격히 고정한 9명의 건강한 자원자를 대상으로 하였다. 채혈은 식전 1시간부터 11시 30분까지 매 시간 실시되었다. 혈장 그렐란, 펩티드 YY3-36, 렙틴 및 인슐린을 방사선면 역법으로 측정하였다. 결과: 혈장 그렐린 농도는 식전에는 588.0±204.4 pg/mL이었고 식후 1시간째는 394.22±145.25 pg/mL으로 감소하였다. 반면에 펩티드 YY3-36는 식전에는 29.9±13.7 pmol/L이었고 식후 1시간째에는 44.2±12.1 pmol/L로 증가하였다. 렙틴은 식전에는7.4±2.7 ng/mL이었고, 식후 1시간째에는 7.1±2.9ng/mL이었다. 반면에 인슐린은 식전에는 129.8±50.0 pmol/mL이었고, 식후 1시간째에는 658.8±332.3 pmol/L로 증가하였다. 혈장 그렐린은 식후 1시간째 최저 농도이었고, 펩티드 YY3-36는 식후 1시간째 최고 농도이었다. 결론 혈장 그렐린은 식후 1시간째 최저인 반면에 펩티드 YY3-36는 식후 l시간째 최고 농도이었다. 이는 혈장 그렐린과 펩티드 YY3-36가 식사에 띠라 같은 속도로 반대방향으로 반응한다는 것을 시사하는 소견이다. Background: Ghrelin and Peptide YY3-36 are gastrointestinal hormones related energy homeostasis. We investigated the changes in post-meal plasma ghrelin and PYY3-36 levels in people after meal, simultaneously. Methods: Nine healthy volunteers adhered to strict meal rimes starting two weeks before the study. Blood was drawn hourly for 4 hours. Plasma ghrelin, PYY3-36, leptin, and insulin levels were measured by radioimmunoassay. (RIA). Results: The mean plasma ghrelin level in subjects consuming the meal was 588.0±204.4 pg/mL just before breakfast and 394.22±145.25 pg/mL 1 h after meal, with the mean plasma PYY3-36 levels of 29.9±13.7 pmol/L and 44.2±12.1 pmol/L, respectively. The mean plasma leptin level in subjects consuming the meal was 7.4±2.7 ng/mL before the meal and 7.1±2.9 ng/mL 1 h after meal, with insulin levels of 129.8±50.0 pmol/L and 658.8±332.3 pmol/L, respectively. Plasma ghrelin levels were lowest 1 h after the meal. although PYY 3-36 levels were highest 1 h after the meal. Conclusion: While plasma ghrelin levels were lowest 1 h, PYY 3-36 levels were highest 1 h after the meal. These findings suggest that Plasma ghrelin and peptide YY3-36 levels change in opposite ways at the same speed.
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부산지역 의과대학생을 대상으로 한 응급처치 및 심폐소생술 교육 경험
오인호(In-Ho Oh),이상엽(Sangyeoup Lee),민홍기(Hong-Gi Min),김영주(Young-Joo Kim),임지향(Jie-Hyang Lim),김형회(Hyoung Hoi Kim),전태용(Tae Yong Jeon),김윤진(Yun-Jin Kim),조석주(Suk-Ju Jo),배석주(Suk-Ju Bae) 한국의학교육학회 2005 Korean journal of medical education Vol.17 No.1
Purpose: The aim of this study was to describe the experience of teaching emergency management and cardiopulmonary resuscitation to medical students in Busan. Methods: Study participants were 59 medical students in Busan. An eight-day curriculum in the emergency management and cardiopulmonary resuscitation was developed. They completed all class sessions and two drill/practical examinations taught by our interdisciplinary team from July 21 through 30, 2003. Each class is approximately 2 hours and reading assignments are given at the end of each class. Also included are practical, table-top and team-building exercises. The participants completed self-reported questionnaires for the education. Results: About establishment and environment of the education, respondents answered with `very good were 14%. About overall theoretical lecture, respondents answered with `very helpful were lower than 40%. Especially, favorable evaluation for the medical lectures was lower than that of other lectures. Students generally enjoyed their emergency medicine experience as it is often their first opportunity to assume primary responsibility for patient care. About overall practices, respondents answered with very helpful were higher than 60%. Conclusion: The authors found that medical students prefer opportunities to hone procedural skills than to hear theoretical lectures. Also, medical students are welcome to hear theoretical lectures that consists of emergency management related contents, not academically medical contents. This curriculum should be tailored to fulfill learner s requirements.
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