조위승청탕(調胃升淸湯) 전탕액(煎湯液)이 XO/HX에 의해 손상(損傷)된 배양(培養) 해마신경세포(海馬神經細胞)에 미치는 효과(效果)

김형순,김경요,고기덕,김일환,송승연,Kim, Hyoung-Soon,Kim, Kyung-Yo,Go, Gi-Deok,Kim, Il-Hwan,Song, Seung-Yun 사상체질의학회 2002 사상체질의학회지 Vol.14 No.1

Jowiseungcheongtang(JST) has been in Sasang constitution medicine for many years as a therapeutic agent for cerebral disease. But the effect of Jowiseungcheongtang(JST) on neurotoxicity is not known. The purpose of this study was to determine the effects of Jowiseungcheongtang(JST) on the hippocampal cell injured by Xanthine Oxidase/Hypoxanthine. The results were as follows: 1. XO/HX decreased the survival rate of the cultured hippocampal cells on NR assay and MTT assay. 2. JST water extract have efficacy of decreasing a amount of lipid peroxidation increased by XO/HX in cultured hippocampal cells. 3. JST water extract have efficacy of increasing DNA synthesis decreased by XO/HX in cultured hippocampal cells. From the above results, It is concluded that JST has marked efficacy in preventing cultured hippocampal cells from the damages by XO/HX.

외국인이 인식하는 한의학 의료관광의 가능성 및 사상체질진단 경제적 가치평가

김형순,이희승,차병헌,주종천,Kim, Hyoung-Soon,Lee, Hee-Seung,Cha, Byung-Hun,Joo, Jong-Cheon 사상체질의학회 2011 사상체질의학회지 Vol.23 No.1

1. Objectives : This study aimed to provide practical insights on the development of traditional Korean medical tourism and maximize the satisfaction of foreign patients. The main objectives of this study were also to evaluate Sasang Constitutional Medicine(S.C.M.) diagnosis cost from foreigners' perspectives. 2. Methods : For this study, the data were collected from tourists to Korea between January 3, 2010 to February 20, 2010. The sample used in this study was mainly composed of Japanese, Chines and US/Canada, because they are the major national visitor origin group to Korea. The primary data were collected by questionnaire survey using a standardized instrument with a convenience sampling procedure, and efforts of the interviews involved an on-site, self-administrated questionnaire to those sitting or visiting tourist attractions. The total size of the sample was 276 of which 275 showed no missing value against the factors needed for final analysis and were for analysis as an effective sample. SPSS 13.0 for window was used to analyze the collected data on which descriptive statistics and the Limited Dependent(LIMDEP) 8.0 program was used in estimating the willingness-to-pay(WTP) for traditional Korean medical tourism through the Contingent Valuation Method(CVM). A dichotomous choice question form of a CVM was applied to estimating the value. 3. Results and Conclusion: 1. There was significant statistical relationship between attributes when considering medical tourism destination and socio-demographic profiles such as age group, nationality, educational level and occupation. 2. In the level of recognition on Korean medicine, north Americans showed low level of recognition compared to other nationalities. In addition, in terms of age group, 20's and 30's showed low level of recognition on Korean medicine, 3. In relation to the level of interest on Korean medicine, Japanese respondents had higher interesting level on Korean medicine. Also singles had higher level of interest. 4. Regarding preferred Korean medical treatment program, there found significant statistical relationship between Korean medical treatment program and socio-demographic characteristics. 5. The estimating result of the logit model showed that the variables affecting the WTP for Sasang Constitutional medicine diagnosis were offered price and potential ability of medical tourism destination. 6. In relation to WTP for Sasang Constitutional medicine diagnosis, Japanese respondents showed a WTP of USD 62.69 and Chinese respondents showed USD 57.09. On the other hands, respondents from north America and other countries showed a WTP of USD 65.50. In conclusion, from this study, the results found that the opportunities in tradition Korean medical tourism are immense and the possible rewards are numerous. It is time to continue to promote 'Sasang Constitutional medicine' and make the Korean medical tourism programs considering on nationalities, age group, gender and WTP.

십이미관중탕(十二味寬中湯)과 오수유부자리중탕(吳茱萸附子理中湯)의 간손상(肝損傷) 보호작용(保護作用)에 대한 연구

김형순,배영춘,이상민,김경요,원경숙,이경성,Kim, Hyoung-Soon,Bae, Young-Chun,Lee, Sang-Min,Kim, Kyung-Yo,Won, Kyung-Sook,Lee, Kyung-Seong 사상체질의학회 2003 사상체질의학회지 Vol.15 No.1

Osuyubujaijung-tang(OBT) and Sipyimiguanjung-tang(SGT) has been developed as prescriptions for the Soyeumin constitution. The hepatoprotective effect of the water extract of Osuyubujaijung-tang(OBT) and Sipyimiguanjung-tang(SGT) was investigated against carbon tetrachloride (CCl4)-induced hepatic damage. A single intra-peritoneal injection of CCl4 produced liver damage in rats as manifested by the significant rise of aspartate aminotransferase(AST), alanine aminotransferase(ALT), and alkaline phosphatase(ALP) in serum as compared to those of untreated normal group. Pretreatments of rats with Osuyubujaijung-tang(OBT) and Sipyimiguanjung-tang(SGT) 500 mg/kg for 7 days) were significantly reduced AST, ALT, and ALP levels compared with CCl4-treated control group. Treatment of rats with CCl4 led to significantly increase in lipid peroxidation and significantly decrease in cytochrome P450 and P450 reductase. The oral administration of Osuyubujaijung-tang(OBT) and Sipyimiguanjung-tang(SGT) water extract significantly inhibited the accumulation of microsomal thiobarbituric acid reactive substance (TBARS) and increased the cytochrome P450 and P450 reductase activity. All these biochemical alterations resulting from CCl4 administration were inhibited by the pretreatment with Osuyubujaijung-tang(OBT) and Sipyimiguanjung-tang(SG1) extract. These results suggest that Osuyubujaijung-tang(OBT) and Sipyimiguanjung-tang(SGT) water extract can be useful as a hepatoprotective agent. And the effect of NO modulation by NO synthesis or precursors, and Osuyubujaijung-tang(OBT) and Sipyimiguanjung-tang (SGT) water extract was researched on chronic liver damage induced by CCl4 administration. It was observed that endogenous NO protected the liver from lipid peroxidation, fibrosis, and damage. Osuyubujaijung-tang(OBT) and Sipyimiguanjung-tang(SGT) water extract showed the hepatoprotective effect on the chronic liver cirrhosis model and relationship with NO modulation.

열다한소탕(熱多寒少湯)이 저산소성(低酸素性) 대뇌신경세포(大腦神經細胞) 손상에 미치는 영향(影響)

김형순,배영춘,이상민,김경요,원경숙,심규헌,박수정,Kim, Hyoung-Soon,Bae, Young-Chun,Lee, Sang-Min,Kim, Kyung-Yo,Won, Kyoung-Sook,Sihm, Gyue-Hearn,Park, Su-Jeong 사상체질의학회 2003 사상체질의학회지 Vol.15 No.1

To elucidate the neuroprotective effect of Yeoldahanso-tang(YHT) on nerve cells damaged by hypoxia, the cytotoxic effects of exposure to hypoxia were determined by XTT(SODIUM3,3'-{I-[(PHENYLAMINO) CARBONYL]-3,4-TETRAZOLIUM}- BIS (4-METHOXY-6-NITRO) BENZENE SULFONIC ACID HYDRATE), NR(Neutral red), MTT(3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) and SRB(Sulforhodamin B) asssay. The activity of catalase and SOD(Superoxide dismutase) was measured by spectrophometry, and $TNF-{\alpha}$(Tumor cell necrosis $fector-{\alpha}$) and PKC(Protein kinase C) activity was measured after exposure to hypoxia and treatment of YHTWE. Also the neuroprotective effect of YHTWE was researched for the elucidatioion of neuroprotective mechanism. The results were as follows; 1. Hypoxia decreased cell viability measured by XTT, NR assay when cultured cerebral neurons were exposed to 95% N2/5% CO2 for $2{\sim}26$ minutes in these cultures and YHTWE inhibited the decrease of cell viability. 2. H2O2 treatment decreased cell viability measured by MTT, and SRB assay when cultured cerebral neurons were exposed to 1-80 ${\mu}M$ for 6 hours, but YHTWE inhibited the decrease of cell viability. 3. Hypoxia decreased catalase and SOD activity, and also $TNF-{\alpha}$ and PKC activity in these cultured cerebral neurons, but YHTWE inhibited the decrease of the catalase and SOD activity in these cultures. 4. Hypoxia triggered the apoptosis via caspase activation and internucleosomal DNA fragmentation. Also hypoxia stimulate the release of cytochrome c forom mitochondria. YHTWE inhibited the apoptosis via caspase activation induced by hypoxia. From these results, it can be suggested that brain ischemia model induced hypoxia showed neurotoxicity on cultured mouse cerebral neurons, and the YHTWE has the neuroprotective effect in blocking the neurotoxicity induced by hypoxia in cultured mouse cerebral neurons.

심플렉스 중심배열법의 일부실시에 관한 연구

김형순,박동권,Kim, Hyoung Soon,Park, Dong Kwon 한국데이터정보과학회 2015 한국데이터정보과학회지 Vol.26 No.6

혼합물 실험으로부터 실험자는 주효과와 저차의 상호작용 효과의 추정을 원한다. 이를 위해 심플렉스 중심배열법과 같은 적절한 실험을 통해 추정할 수 있다. 그러나, 요인의 수가 늘어나면 부득이 일부실시를 행하게 된다. 이 경우 각 성분의 혼합비율의 합이 일정하다는 제약 조건은 교락으로 인해 추정가능한 상호작용의 선택을 어렵게 한다. 이러한 문제를 해결하기 위해 본 논문에서는 $Scheff{\acute{e}}$의 정준 모형 대신에 대수기하학을 기초로 한 동차다항식 (homogeneous polynomial)으로 구성된 모형을 도입하여 문제를 풀려고 한다. 이를 활용하여 심플렉스 중심배열법의 일부실시법에 대해 추정가능한 모형을 제시한다. 연산은 CoCoA 대수연산 소프트웨어를 이용하였다. In a mixture experiment, one may be interested in estimating not only main effects but also some interactions. Main effects and interactions may be estimated through appropriate designs such as simplex-centroid designs. However, the estimability problems, implied by the sum to one functional relationship among the factors, have strong consequences on the confounding and identifiability of models for such designs. To handle these problems, we address homogeneous polynomial model based on the computational commutative algebra (CCA) instead of using $Scheff{\acute{e}}s$ canonical model which is typically used. The problem posed here is to give how to choose estimable main effects and also some low-degree interactions. The theory is tested using a fraction of simplex-centroid designs aided by a modern computational algebra package CoCoA.

그뢰브너 기저와 지시함수와의 관계

김형순,박동권,Kim, Hyoung-Soon,Park, Dong-Kwon 한국데이터정보과학회 2009 한국데이터정보과학회지 Vol.20 No.6

대수기하학적 접근이란 실험계획에서의 공간 내의 점들 즉, 기하학적 대상인 다양체에 대한 문제를 다항식을 매개로 하여 아이디얼 즉, 대수적 문제로 전환하고자 한 것이라 할 수 있다. 지금까지의 연구는 완전요인실험으로부터 효율적인 부분요인실험을 선택하는 절차에 집중되어 왔다. 본 논문에서는 지금까지 연구 방법의 역의 과정을 추정해 보기로 한다. 한 부분요인실험이 선택되었을 때, 그 실험의 교락구조를 그뢰브너 기저를 구한 후 해석한다. 다음으로 그뢰브너 기저를 생성자로 활용하여 선택된 부분실험의 집합을 구별하기 위한 다항함수인 지시함수를 구하는 절차를 알아보기로 한다. 실제로 몇 가지 부분요인실험을 예로 택하여 그 과정을 수행하였다. 연산은 CoCoA 대수연산 소프트웨어를 이용하였다. Many problems of confounding and identifiability for polynomial models in an experimental design can be solved using methods of algebraic geometry. The theory of $Gr\ddot{o}bner$ basis is used to characterize the design. In addition, a fractional factorial design can be uniquely represented by a polynomial indicator function. $Gr\ddot{o}bner$ bases and indicator functions are powerful computational tools to deal with ideals of fractions based on each different theoretical aspects. The problem posed here is to give how to move from one representation to the other. For a given fractional factorial design, the indicator function can be computed from the generating equations in the $Gr\ddot{o}bner$ basis. The theory is tested using some fractional factorial designs aided by a modern computational algebra package CoCoA.

21세기 블루오션, 한의학의료관광활성화를 위한 탐색적 연구

김형순,주종천,Kim, Hyoung-Soon,Joo, Jong-Cheon 사상체질의학회 2009 사상체질의학회지 Vol.21 No.2

1. Objective : This study aims to evaluate the medical tourism structures in countries with prosperous medical tourism industry such as Thailand, Malaysia, Singapore and India in order ro propose optimal strategies that can promote the medical tourism in Korea. 2. Methods : All pertinent literature concerning medical tourism directly and indirectly were assessed, and reviews of medical tourism strategies found in various countries were evaluated. 3. Results : Evaluation of related literature reveals that medical tourism is a recent burgeoning industry that has grown In market size considerably in the last five to ten years. Also, it shows that oriental medicine is a highly likely candidate amidst the various medical fields for attraction foreign patients. 4. Conclusion : The Korean government should support and install appropriate legal and administrative bodies in order to attract medical tourists; Korea-specific medical tourism programs (ie. traditional Korean medicine package tours) should be developed in order to attract medical tourists from the western world and the middle-east. In addition, low-price policy of medical tourism is not a proper strategies for the competition against advanced medical tourism destinations such as Thailand, Malaysia, Singapore and India. Differentiated medical tourism package such as oriental medical tourism program rather than provision of low-price policy seems to be more effective strategy for the medical tourism in Korea. Future studies on strategies for promoting medical tourism should focus on how foreigners recognize traditional Korean medicine, what diagnostic approach might be appealing to them and how the legal system concerning the medical procedures may be altered and modified.

보령시 보령머드축제 성공사례

김형순(Kim Hyoung-Soon),김원겸(Kim Won-Kyum) 한국상품학회 2005 商品學硏究 Vol.23 No.2

Boryeoung city has devoted itself to industrialize mud which is regionally abundant, and to develop it as the cultural tourism festival in connection with Daecheon Beach. As a result, the Boryeoung Mud Festival was designated as one of the excellent festivals in 1998 by the Ministry of Culture and Tourism. Lots of domestic and foreign tourists have visited there and so the regional economy has been greatly affected. And it has been settled as the representative culture festival which records the highest participation rate of foreign tourists. Recently various regional festivals have increased in quantity and so restructuring of cultural tourism festivals are required. The Boryeoung Mud Festival enables human beings to directly feel and experience natural benefits through mud which is a natural resource and so it has been firmly established as the differential cultural festival from other regional festivals. To make the Boryeoung Mud Festival develop as the worldwide cultural event in the future, it is regarded that its marketing mix should be generally compensated according to a change of environment.

4차 산업혁명시대의 영어교사 미래준비도 연구

김형순 ( Kim Hyoung Soon ),김혜영 ( Kim Heyong ) 한국멀티미디어언어교육학회 2017 멀티미디어 언어교육 Vol.20 No.3

The purpose of this study is to investigate English teachers’ preparedness in terms of knowledge, attitudes, and perceptions about the upcoming future, namely, the fourth industrial revolution era. To create a questionnaire form, this study defines English teachers’ future readiness in the following categories; 1) technology knowledge and concerns, 2) innovation resistance and anxiety, 3) perceptions toward a new technology impact on English education. The analysis of the survey data yielded the following findings. First of all, teachers’ concern about the impact of new technology on English education was high, but their concern level seemed ‘personal’ (1-2 stages), as well as unrelated to their teaching. In addition, they were comparatively less interested in building knowledge about new technologies. Second, the teachers’ innovation resistance and anxiety were not high. The teachers showed willingness to take new technologies as instructional tools and positive attitude toward technology-embedded future classroom. Third, notwithstanding, they did not believe that new technology would change the existing language education paradigm and solve the problems inside. Younger teachers showed significantly higher skepticism on the future changes.

e-서비스품질요인이 고객만족과 관계유지의도에 미치는 영향

김형순(Kim, Hyoung-Soon),김원겸(Kim, Won-Kyum),범경기(Fan, Qing ji),석서(Shi, Shu) 한국상품학회 2009 商品學硏究 Vol.27 No.2

본 연구의 주된 목적은 웹 사이트 서비스품질요인과 고객만족 및 관계유지의도간의 관계를 규명하고자 하는 것이다. 이를 위해 웹 사이트 서비스의 신뢰성, 편리성, 콘텐츠, 오락성, 커뮤니케이션, 디자인 등 웹 사이트 서비스 평가차원을 독립변수로 선정하였다. 고객이 웹 사이트에 대한 고객의 만족을 매개변수로 설정하고, 종속변수인 소비자의 관계유지의도간의 인과관계를 나타내는 연구모형과 가설을 설정하였다. 평가 모형의 활용도 제고를 위하여 웹 사이트 유형별로 e-서비스품질요인들이 고객만족에 미치는 영향의 효과차이를 분석하였다. 본 연구의 실증분석 결과는 웹 사이트 서비스품질요인을 밝혀냈고, 고객이 웹 사이트에 대해 만족할수록 앞으로 웹 사이트와 지속적인 관계를 유지할 가능성이 높은 것으로 분석되었다. 마지막으로 본 연구에서 웹 사이트 유형에 따라 서비스품질요인이 고객만족에 미치는 영향의 효과차이가 있는 것을 밝혀냈다. 이러한 연구결과에 의하면 실무적으로는 웹 사이트 운영기업들이 웹 사이트를 운영할 수 있는 새로운 방법을 제공해 줄 수 있을 것이다. The purpose of this study is to investigate the impacts of e-service quality factors on customer satisfaction and relationship intention by Web site types. Difference and moderating effect resulting from the type of web site users about an association with reaction of satisfaction and those component concepts are also one of the aims in the study. As the results, the study found that factors of web site service quality variables has a positive impact on customer satisfaction. And customer satisfaction also has a positive impact on relationship intention. Furthermore, through the comparative analysis, we found that the service quality differed on the effects of customer satisfaction by web site types. According to those results, marketing managers should develop different service strategies based on different web site types.