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항돌연변이 작용을 보이는 Flavonoid 인 galangin 의 마우스에서의 BP 대사의 영향
김희기,김경호,허문영,김현표 ( Hee Kee Kim,Kyeong Ho Kim,Moon Young Heo,Hyun Pyo Kim ) 생화학분자생물학회 1991 BMB Reports Vol.24 No.2
To elucidate the antimutagenic action mechanism of flavonoids against benzo(a)pyrene induced micronucleated polychromatic erythrocytes (MNPCEs), alterations of benzo(a) pyrene metabolism were studied. Galangin, a potent antimutagen and (-)-epicatechin, a weak one, were selected and orally administered to ICR mice to compare the liver metabolic enzyme activities, arylhydrocarbon hydroxylase (AHH) and glutathione-s-transferase (GSH-T). These enzyme activities were not significantly changed between the flavonoid-treated groups and the control group. However, direct addition of galangin to the incubation mixture clearly inhibited arylhydrocarbon hydroxylase activity. These results were well correlated with the findings of the reduced metabolic conversion of [³H]-benzo(a)pyrene in vitro.
Inhibition of Rat Adjuvant-Induced Arthritis by Ginkgetin, a Biflavone from Ginkgo biloba Leaves
Kim, Hee Kee,Son, Kun Ho,Chang, Hyeun Wook,Kang, Sam Sik,Kim, Hyun Pyo 영남대학교 약품개발연구소 1999 영남대학교 약품개발연구소 연구업적집 Vol.9 No.-
Ginkgetin, a biflavone isolated from Ginkgo bilobα loaves, was previously reported as an inhibitor of group Ⅱ phos-pholipase A(2). In this study, ginkgetin was evaluated for in vivo antiarthritic and analgesic activities. Ginkgetin (10-20 mg/kg/day) Strongly reduced arthritic inflammation in an animal model of rat adjuvant-induced arthritis (86% inhibition at 16 days at a dose of 20 mg/kg/day) via intraperitoneal injection, while predni-solone (5 mg/kg/day) showed 79% reduction. Histological ex-amination of the knee joints confirmed our findings. When anal-gesic activity was measured, ginkgetin showed a dose-depend-ent inhibition in an animal model of acetic acid-induced writhing. ED(50) values for ginkgetin and indomethacin were 8.9 and 3.8 mg/kg, respectively. All these results indicate that ginkgetin may be a potential antiarthritic agent having analgesic activity.
Amentoflavone, a Plant Biflavone : A New Potential Anti-inflammatory Agent
Kim, Hee Kee,Son, Kun Ho,Chang, Hyeun Wook,Kang, Sam Sik,Kim, Hyun Pyo 영남대학교 약품개발연구소 1999 영남대학교 약품개발연구소 연구업적집 Vol.9 No.-
Biflavonoid is one of unique classes of naturally-occurring bioflavonoids. Certain biflavonoids including amentoflavone were previously reported to have inhibitory effect on the group Ⅱ phospholipase A(2) activity. Amentoflavone was also found to inhibit cyclooxygenase from guinea-pig epidermis without affecting lipoxygenase. In this study, anti-inflammatory and analgesic activities of amentoflavone were evaluated . When amentoflavone was administered intraperitoneally, it showed a potent anti-inflammatory activity as determined by amelioration of croton-oil induced mouse ear edema. It also showed a potent anti-inflammatory activity in the rat carrageenan paw edema model (ED(50)=42 mg/kg) compared to the activity of prednisolone (35 mg/kg) and indomethacin (10 mg/kg). However, amentoflavone did not show a significant inhibitory activity against rat adjuvant-induced arthritis, a chronic inflammatory model. In addition, amentoflavone was found to possess a potent analgesic activity in the acetic acid writhing test (ED(50)=9.6 mg/kg) compared to the activity of indomethacin (3.8 mg/kg). These results suggest that amentoflavone may be a potential lead for a new type of anti-inflammatory agents having dual inhibitory activity of group Ⅱ phospholipase A(2) and cyclooxygenase.